P49585: Choline-phosphate cytidylyltransferase A

General Information

Protein names	- Choline-phosphate cytidylyltransferase A - 2.7.7.15 {ECO:0000250\|UniProtKB:P19836} - CCT-alpha - CTP:phosphocholine cytidylyltransferase A - CCT A - CT A - Phosphorylcholine transferase A
Gene names	PCYT1A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49585

4 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDAQCSAKVN ARKRRKEAPG PNGATEEDGV PSKVQRCAVG LRQPAPFSDE IEVDFSKPYV
        70         80         90        100        110        120
RVTMEEASRG TPCERPVRVY ADGIFDLFHS GHARALMQAK NLFPNTYLIV GVCSDELTHN
       130        140        150        160        170        180
FKGFTVMNEN ERYDAVQHCR YVDEVVRNAP WTLTPEFLAE HRIDFVAHDD IPYSSAGSDD
       190        200        210        220        230        240
VYKHIKEAGM FAPTQRTEGI STSDIITRIV RDYDVYARRN LQRGYTAKEL NVSFINEKKY
       250        260        270        280        290        300
HLQERVDKVK KKVKDVEEKS KEFVQKVEEK SIDLIQKWEE KSREFIGSFL EMFGPEGALK
       310        320        330        340        350        360
HMLKEGKGRM LQAISPKQSP SSSPTRERSP SPSFRWPFSG KTSPPCSPAN LSRHKAAAYD

ISEDEED

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P49585-1-Acetylation	MDAQCS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49585-1-Acetylation	MDAQCS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P49585-1-Acetylation	MDAQCS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P49585-29-unknown	GVPSKV...	29		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3076
P49585-29-unknown	GVPSKV...	29		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2567
P49585-29-unknown	GVPSKV...	29		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3189
P49585-67-unknown	ASRGTP...	67		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000402283
P49585-128-unknown	NENERY...	128		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000390458

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ATEEDG	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3076
...ATEEDG	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2567
...ATEEDG	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3189
...GVCSDE	115	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000393341
...ENERYD	133	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000402015
...FLEMFG	293	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000400430
...EDEED	367	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP8_HUMAN	28	EEDG.\|.GVPS	inferred from experiment	unknown	MEROPS	Ridgway ND	Lagace TA et al.:Caspase processing and nuclear ... (C14.005)	12052891,
CASP6_HUMAN	28	EEDG.\|.GVPS	inferred from experiment	unknown	MEROPS	Ridgway ND	Lagace TA et al.:Caspase processing and nuclear ... (C14.005)	12052891,
CASP9_HUMAN	28	EEDG.\|.GVPS	inferred from experiment	unknown	MEROPS	Ridgway ND	Lagace TA et al.:Caspase processing and nuclear ... (C14.005)	12052891,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)