P30990: Neurotensin/neuromedin N

General Information

Protein names	- Neurotensin/neuromedin N - Large neuromedin N - NmN-125 - Neuromedin N - NN - NmN - Neurotensin - NT - Tail peptide
Gene names	NTS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P30990

11 N-termini

11 C-termini

22 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MMAGMKIQLV CMLLLAFSSW SLCSDSEEEM KALEADFLTN MHTSKISKAH VPSWKMTLLN
        70         80         90        100        110        120
VCSLVNNLNS PAEETGEVHE EELVARRKLP TALDGFSLEA MLTIYQLHKI CHSRAFQHWE
       130        140        150        160        170
LIQEDILDTG NDKNGKEEVI KRKIPYILKR QLYENKPRRP YILKRDSYYY

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

11 N-termini - 11 C-termini - 22 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P30990-24-unknown	SDSEEE...	24	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P30990-152-unknown	LYENKP...	152	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27399
P30990-153-unknown	YENKPR...	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8580
P30990-154-unknown	ENKPRR...	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17567
P30990-154-unknown	ENKPRR...	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31908
P30990-154-unknown	ENKPRR...	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC750
P30990-154-unknown	ENKPRR...	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1013
P30990-155-unknown	NKPRRP...	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17568
P30990-156-unknown	KPRRPY...	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16753
P30990-158-unknown	RRPYIL...	158	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8
P30990-159-unknown	RPYILK...	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17569
P30990-159-unknown	RPYILK...	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31707
P30990-161-unknown	YILKRD...	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8581
P30990-161-unknown	YILKRD...	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26757
P30990-161-unknown	YILKRD...	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8591
P30990-161-unknown	YILKRD...	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26772
P30990-162-unknown	ILKRDS...	162	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26758
P30990-162-unknown	ILKRDS...	162	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8592
P30990-162-unknown	ILKRDS...	162	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3769
P30990-162-unknown	ILKRDS...	162	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8431
P30990-163-unknown	LKRDSY...	163	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9
P30990-163-unknown	LKRDSY...	163	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8227
P30990-163-unknown	LKRDSY...	163	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8266

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IPYILK	148	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ILKRQL	151	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27399
...LKRQLY	152	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8580
...KRQLYE	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17567
...KRQLYE	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31908
...KRQLYE	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC750
...KRQLYE	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1013
...RQLYEN	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17568
...QLYENK	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16753
...YENKPR	157	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8
...ENKPRR	158	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17569
...ENKPRR	158	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31707
...KPRRPY	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8581
...KPRRPY	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26757
...KPRRPY	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8591
...KPRRPY	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26772
...PRRPYI	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26758
...PRRPYI	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8592
...PRRPYI	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3769
...PRRPYI	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8431
...RRPYIL	162	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9
...RRPYIL	162	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8227
...RRPYIL	162	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8266

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PGPI_HUMAN	151	KRQL.\|.LYEN	inferred from experiment	unknown	MEROPS	Casis L	De Gandarias JM et al.:Developmental changes of pyrogl... (C15.010)	7989161,
ECE1_HUMAN	152	RQLY.\|.YENK	inferred from experiment	unknown	MEROPS	Turner AJ	Carson JA et al.:Characterization of PgPepO, a b... (M13.002)	12193062,
MEP1A_HUMAN	153	QLYE.\|.ENKP	inferred from experiment	unknown	MEROPS	Bond JS	Bylander JE et al.:Human and mouse homo-oligomeric... (M12.002)	17976009,
TPP1_HUMAN	153	QLYE.\|.ENKP	inferred from experiment	unknown	MEROPS	Ohkubo I	Du PG et al.:Rat tripeptidyl peptidase I: mo... (S53.003)	11843185,
CAN1_HUMAN	153	QLYE.\|.ENKP	inferred from experiment	unknown	MEROPS	Pennington RJ	McDermott JR et al.:Specificity of neuropeptide deg... (C02.001)	2410757,
CAN2_HUMAN	153	QLYE.\|.ENKP	inferred from experiment	unknown	MEROPS	Pennington RJ	McDermott JR et al.:Specificity of neuropeptide deg... (C02.001)	2410757,
MEP1A_HUMAN	154	LYEN.\|.NKPR	inferred from experiment	unknown	MEROPS	Bond JS	Bylander JE et al.:Human and mouse homo-oligomeric... (M12.002)	17976009,
LGMN_HUMAN	155	YENK.\|.KPRR	inferred from experiment	unknown	MEROPS		Merops LGMN_HUMAN -> NEUT_HUMAN @155
ACE2_HUMAN	157	NKPR.\|.RRPY	inferred from experiment	unknown	MEROPS	Tummino P	Vickers C et al.:Hydrolysis of biological peptid... (M02.006)	11815627,
MEP1A_HUMAN	158	KPRR.\|.RPYI	inferred from experiment	unknown	MEROPS	Bond JS	Bylander JE et al.:Human and mouse homo-oligomeric... (M12.002)	17976009,
THOP1_HUMAN	158	KPRR.\|.RPYI	inferred from experiment	unknown	MEROPS		Merops THOP1_HUMAN -> NEUT_HUMAN @158
ECE1_HUMAN	160	RRPY.\|.YILK	inferred from experiment	unknown	MEROPS		Merops ECE1_HUMAN -> NEUT_HUMAN @160
NEP_HUMAN	160	RRPY.\|.YILK	inferred from experiment	unknown	MEROPS		Merops NEP_HUMAN -> NEUT_HUMAN @160
ECE2_HUMAN	160	RRPY.\|.YILK	inferred from experiment	unknown	MEROPS	Devi LA	Mzhavia N et al.:Characterization of endothelin-... (M13.003)	12560336,
NEUL_HUMAN	160	RRPY.\|.YILK	inferred from experiment	unknown	MEROPS		Merops NEUL_HUMAN -> NEUT_HUMAN @160
NEP_HUMAN	161	RPYI.\|.ILKR	inferred from experiment	unknown	MEROPS		Merops NEP_HUMAN -> NEUT_HUMAN @161
ECE2_HUMAN	161	RPYI.\|.ILKR	inferred from experiment	unknown	MEROPS	Devi LA	Mzhavia N et al.:Characterization of endothelin-... (M13.003)	12560336,
CATB_HUMAN	161	RPYI.\|.ILKR	inferred from experiment	unknown	MEROPS	Tang J	Takahashi T et al.:Porcine spleen cathepsin B is a... (C01.060)	3522589,
CMA1_HUMAN	161	RPYI.\|.ILKR	inferred from experiment	unknown	MEROPS	Caughey GH	Raymond WW et al.:Albumin is a substrate of human... (S01.140)	12815038,
ACE2_HUMAN	162	PYIL.\|.LKRD	inferred from experiment	unknown	MEROPS	Acton S	Donoghue M et al.:A novel angiotensin-converting ... (M02.006)	10969042,
CBPA4_HUMAN	162	PYIL.\|.LKRD	inferred from experiment	unknown	MEROPS	Fricker LD	Tanco S et al.:Characterization of the substra... (M14.017)	20385563,
CBPA6_HUMAN	162	PYIL.\|.LKRD	inferred from experiment	unknown	MEROPS	Fricker LD	Lyons PJ et al.:Characterization of carboxypept... (M14.018)	18178555,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)