Q9NXJ5: Pyroglutamyl-peptidase 1

General Information

Protein names	- Pyroglutamyl-peptidase 1 - 3.4.19.3 - 5-oxoprolyl-peptidase - Pyroglutamyl aminopeptidase I - PAP-I - Pyroglutamyl-peptidase I - PGP-I - Pyrrolidone-carboxylate peptidase
Gene names	PGPEP1
Organism	Homo sapiens
Protease Family	C15.010
Protease ID	C15.010
Chromosome location
UniProt ID	Q9NXJ5

3 N-termini

2 C-termini

0 Cleavages

2 Substrates

Sequence

        10         20         30         40         50         60
MEQPRKAVVV TGFGPFGEHT VNASWIAVQE LEKLGLGDSV DLHVYEIPVE YQTVQRLIPA
        70         80         90        100        110        120
LWEKHSPQLV VHVGVSGMAT TVTLEKCGHN KGYKGLDNCR FCPGSQCCVE DGPESIDSII
       130        140        150        160        170        180
DMDAVCKRVT TLGLDVSVTI SQDAGRYLCD FTYYTSLYQS HGRSAFVHVP PLGKPYNADQ
       190        200
LGRALRAIIE EMLDLLEQSE GKINYCHKH

Isoforms

- Isoform 2 of Pyroglutamyl-peptidase 1

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 2 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9NXJ5-1-unknown	MEQPRK...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9NXJ5-78-unknown	MATTVT...	78	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000252813
Q9NXJ5-110-unknown	EDGPES...	110	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000471130

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...QDAGRY	146	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000475867
	...YCHKH	209	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GON1_HUMAN	26	QHWS.\|.SYGL	inferred from experiment	unknown	MEROPS	Casis L	De Gandarias JM et al.:Developmental changes of pyrogl... (C15.010)	7989161,
NEUT_HUMAN	151	KRQL.\|.LYEN	inferred from experiment	unknown	MEROPS	Casis L	De Gandarias JM et al.:Developmental changes of pyrogl... (C15.010)	7989161,