O60344: Endothelin-converting enzyme 2

General Information

Protein names	- Endothelin-converting enzyme 2 - ECE-2 - Methyltransferase-like region - 2.1.1.- - Endothelin-converting enzyme 2 region - 3.4.24.71
Gene names	ECE2
Organism	Homo sapiens
Protease Family	M13.003
Protease ID	M13.003
Chromosome location	q27.1
UniProt ID	O60344

1 N-termini

1 C-termini

0 Cleavages

11 Substrates

Sequence

Isoforms

- Isoform B of Endothelin-converting enzyme 2 - Isoform C of Endothelin-converting enzyme 2 - Isoform D of Endothelin-converting enzyme 2 - Isoform 2C of Endothelin-converting enzyme 2

Sequence View

        10         20         30         40         50         60
MASPGAGRAP PELPERNCGY REVEYWDQRY QGAADSAPYD WFGDFSSFRA LLEPELRPED
        70         80         90        100        110        120
RILVLGCGNS ALSYELFLGG FPNVTSVDYS SVVVAAMQAR HAHVPQLRWE TMDVRKLDFP
       130        140        150        160        170        180
SASFDVVLEK GTLDALLAGE RDPWTVSSEG VHTVDQVLSE VGFQKGTRQL LGSRTQLELV
       190        200        210        220        230        240
LAGASLLLAA LLLGCLVALG VQYHRDPSHS TCLTEACIRV AGKILESLDR GVSPCEDFYQ
       250        260        270        280        290        300
FSCGGWIRRN PLPDGRSRWN TFNSLWDQNQ AILKHLLENT TFNSSSEAEQ KTQRFYLSCL
       310        320        330        340        350        360
QVERIEELGA QPLRDLIEKI GGWNITGPWD QDNFMEVLKA VAGTYRATPF FTVYISADSK
       370        380        390        400        410        420
SSNSNVIQVD QSGLFLPSRD YYLNRTANEK VLTAYLDYME ELGMLLGGRP TSTREQMQQV
       430        440        450        460        470        480
LELEIQLANI TVPQDQRRDE EKIYHKMSIS ELQALAPSMD WLEFLSFLLS PLELSDSEPV
       490        500        510        520        530        540
VVYGMDYLQQ VSELINRTEP SILNNYLIWN LVQKTTSSLD RRFESAQEKL LETLYGTKKS
       550        560        570        580        590        600
CVPRWQTCIS NTDDALGFAL GSLFVKATFD RQSKEIAEGM ISEIRTAFEE ALGQLVWMDE
       610        620        630        640        650        660
KTRQAAKEKA DAIYDMIGFP DFILEPKELD DVYDGYEISE DSFFQNMLNL YNFSAKVMAD
       670        680        690        700        710        720
QLRKPPSRDQ WSMTPQTVNA YYLPTKNEIV FPAGILQAPF YARNHPKALN FGGIGVVMGH
       730        740        750        760        770        780
ELTHAFDDQG REYDKEGNLR PWWQNESLAA FRNHTACMEE QYNQYQVNGE RLNGRQTLGE
       790        800        810        820        830        840
NIADNGGLKA AYNAYKAWLR KHGEEQQLPA VGLTNHQLFF VGFAQVWCSV RTPESSHEGL
       850        860        870        880
VTDPHSPARF RVLGTLSNSR DFLRHFGCPV GSPMNPGQLC EVW         10         20         30         40         50         60
MASPGAGRAP PELPERNCGY REVEYWDQRY QGAADSAPYD WFGDFSSFRA LLEPELRPED
        70         80         90        100        110        120
RILVLGCGNS ALSYELFLGG FPNVTSVDYS SVVVAAMQAR HAHVPQLRWE TMDVRKLDFP
       130        140        150        160        170        180
SASFDVVLEK GTLDALLAGE RDPWTVSSEG VHTVDQVLSE VGFQKGTRQL LGSRTQLELV
       190        200        210        220        230        240
LAGASLLLAA LLLGCLVALG VQYHRDPSHS TCLTEACIRV AGKILESLDR GVSPCEDFYQ
       250        260        270        280        290        300
FSCGGWIRRN PLPDGRSRWN TFNSLWDQNQ AILKHLLENT TFNSSSEAEQ KTQRFYLSCL
       310        320        330        340        350        360
QVERIEELGA QPLRDLIEKI GGWNITGPWD QDNFMEVLKA VAGTYRATPF FTVYISADSK
       370        380        390        400        410        420
SSNSNVIQVD QSGLFLPSRD YYLNRTANEK VLTAYLDYME ELGMLLGGRP TSTREQMQQV
       430        440        450        460        470        480
LELEIQLANI TVPQDQRRDE EKIYHKMSIS ELQALAPSMD WLEFLSFLLS PLELSDSEPV
       490        500        510        520        530        540
VVYGMDYLQQ VSELINRTEP SILNNYLIWN LVQKTTSSLD RRFESAQEKL LETLYGTKKS
       550        560        570        580        590        600
CVPRWQTCIS NTDDALGFAL GSLFVKATFD RQSKEIAEGM ISEIRTAFEE ALGQLVWMDE
       610        620        630        640        650        660
KTRQAAKEKA DAIYDMIGFP DFILEPKELD DVYDGYEISE DSFFQNMLNL YNFSAKVMAD
       670        680        690        700        710        720
QLRKPPSRDQ WSMTPQTVNA YYLPTKNEIV FPAGILQAPF YARNHPKALN FGGIGVVMGH
       730        740        750        760        770        780
ELTHAFDDQG REYDKEGNLR PWWQNESLAA FRNHTACMEE QYNQYQVNGE RLNGRQTLGE
       790        800        810        820        830        840
NIADNGGLKA AYNAYKAWLR KHGEEQQLPA VGLTNHQLFF VGFAQVWCSV RTPESSHEGL
       850        860        870        880
VTDPHSPARF RVLGTLSNSR DFLRHFGCPV GSPMNPGQLC EVW         10         20         30         40         50         60
MASPGAGRAP PELPERNCGY REVEYWDQRY QGAADSAPYD WFGDFSSFRA LLEPELRPED
        70         80         90        100        110        120
RILVLGCGNS ALSYELFLGG FPNVTSVDYS SVVVAAMQAR HAHVPQLRWE TMDVRKLDFP
       130        140        150        160        170        180
SASFDVVLEK GTLDALLAGE RDPWTVSSEG VHTVDQVLSE VGFQKGTRQL LGSRTQLELV
       190        200        210        220        230        240
LAGASLLLAA LLLGCLVALG VQYHRDPSHS TCLTEACIRV AGKILESLDR GVSPCEDFYQ
       250        260        270        280        290        300
FSCGGWIRRN PLPDGRSRWN TFNSLWDQNQ AILKHLLENT TFNSSSEAEQ KTQRFYLSCL
       310        320        330        340        350        360
QVERIEELGA QPLRDLIEKI GGWNITGPWD QDNFMEVLKA VAGTYRATPF FTVYISADSK
       370        380        390        400        410        420
SSNSNVIQVD QSGLFLPSRD YYLNRTANEK VLTAYLDYME ELGMLLGGRP TSTREQMQQV
       430        440        450        460        470        480
LELEIQLANI TVPQDQRRDE EKIYHKMSIS ELQALAPSMD WLEFLSFLLS PLELSDSEPV
       490        500        510        520        530        540
VVYGMDYLQQ VSELINRTEP SILNNYLIWN LVQKTTSSLD RRFESAQEKL LETLYGTKKS
       550        560        570        580        590        600
CVPRWQTCIS NTDDALGFAL GSLFVKATFD RQSKEIAEGM ISEIRTAFEE ALGQLVWMDE
       610        620        630        640        650        660
KTRQAAKEKA DAIYDMIGFP DFILEPKELD DVYDGYEISE DSFFQNMLNL YNFSAKVMAD
       670        680        690        700        710        720
QLRKPPSRDQ WSMTPQTVNA YYLPTKNEIV FPAGILQAPF YARNHPKALN FGGIGVVMGH
       730        740        750        760        770        780
ELTHAFDDQG REYDKEGNLR PWWQNESLAA FRNHTACMEE QYNQYQVNGE RLNGRQTLGE
       790        800        810        820        830        840
NIADNGGLKA AYNAYKAWLR KHGEEQQLPA VGLTNHQLFF VGFAQVWCSV RTPESSHEGL
       850        860        870        880
VTDPHSPARF RVLGTLSNSR DFLRHFGCPV GSPMNPGQLC EVW         10         20         30         40         50         60
MASPGAGRAP PELPERNCGY REVEYWDQRY QGAADSAPYD WFGDFSSFRA LLEPELRPED
        70         80         90        100        110        120
RILVLGCGNS ALSYELFLGG FPNVTSVDYS SVVVAAMQAR HAHVPQLRWE TMDVRKLDFP
       130        140        150        160        170        180
SASFDVVLEK GTLDALLAGE RDPWTVSSEG VHTVDQVLSE VGFQKGTRQL LGSRTQLELV
       190        200        210        220        230        240
LAGASLLLAA LLLGCLVALG VQYHRDPSHS TCLTEACIRV AGKILESLDR GVSPCEDFYQ
       250        260        270        280        290        300
FSCGGWIRRN PLPDGRSRWN TFNSLWDQNQ AILKHLLENT TFNSSSEAEQ KTQRFYLSCL
       310        320        330        340        350        360
QVERIEELGA QPLRDLIEKI GGWNITGPWD QDNFMEVLKA VAGTYRATPF FTVYISADSK
       370        380        390        400        410        420
SSNSNVIQVD QSGLFLPSRD YYLNRTANEK VLTAYLDYME ELGMLLGGRP TSTREQMQQV
       430        440        450        460        470        480
LELEIQLANI TVPQDQRRDE EKIYHKMSIS ELQALAPSMD WLEFLSFLLS PLELSDSEPV
       490        500        510        520        530        540
VVYGMDYLQQ VSELINRTEP SILNNYLIWN LVQKTTSSLD RRFESAQEKL LETLYGTKKS
       550        560        570        580        590        600
CVPRWQTCIS NTDDALGFAL GSLFVKATFD RQSKEIAEGM ISEIRTAFEE ALGQLVWMDE
       610        620        630        640        650        660
KTRQAAKEKA DAIYDMIGFP DFILEPKELD DVYDGYEISE DSFFQNMLNL YNFSAKVMAD
       670        680        690        700        710        720
QLRKPPSRDQ WSMTPQTVNA YYLPTKNEIV FPAGILQAPF YARNHPKALN FGGIGVVMGH
       730        740        750        760        770        780
ELTHAFDDQG REYDKEGNLR PWWQNESLAA FRNHTACMEE QYNQYQVNGE RLNGRQTLGE
       790        800        810        820        830        840
NIADNGGLKA AYNAYKAWLR KHGEEQQLPA VGLTNHQLFF VGFAQVWCSV RTPESSHEGL
       850        860        870        880
VTDPHSPARF RVLGTLSNSR DFLRHFGCPV GSPMNPGQLC EVW

Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 11 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60344-1-unknown	MASPGA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60344-1-unknown	MASPGA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73577

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LCEVW	883	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LCEVW	883	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69194
...LCEVW	883	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69193
...LCEVW	883	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69196

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ANGT_HUMAN	40	IHPF.\|.FHLV	inferred from experiment	unknown	MEROPS	Devi LA	Mzhavia N et al.:Characterization of endothelin-... (M13.003)	12560336,
TKN1-Isoform2_HUMAN	66	FFGL.\|.LMGK	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8589
TKN1_HUMAN	66	FFGL.\|.LMGK	inferred from experiment	unknown	MEROPS	Devi LA	Mzhavia N et al.:Characterization of endothelin-... (M13.003)	12560336,
EDN1_HUMAN	73	IIWV.\|.VNTP	inferred from experiment	unknown	MEROPS	Devi LA	Mzhavia N et al.:Characterization of endothelin-... (M13.003)	12560336,
NEUT_HUMAN	160	RRPY.\|.YILK	inferred from experiment	unknown	MEROPS	Devi LA	Mzhavia N et al.:Characterization of endothelin-... (M13.003)	12560336,
NEUT_HUMAN	161	RPYI.\|.ILKR	inferred from experiment	unknown	MEROPS	Devi LA	Mzhavia N et al.:Characterization of endothelin-... (M13.003)	12560336,
PDYN_HUMAN	233	RRQF.\|.FKVV	inferred from experiment	unknown	MEROPS	Devi LA	Mzhavia N et al.:Characterization of endothelin-... (M13.003)	12560336,
PDYN_HUMAN	235	QFKV.\|.VVTR	inferred from experiment	unknown	MEROPS	Devi LA	Mzhavia N et al.:Characterization of endothelin-... (M13.003)	12560336,
KNG1-Isoform3_HUMAN	351	FSPF.\|.FRSS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8583
KNG1_HUMAN	387	FSPF.\|.FRSS	inferred from experiment	unknown	MEROPS	Devi LA	Mzhavia N et al.:Characterization of endothelin-... (M13.003)	12560336,
KNG1-Isoform2_HUMAN	387	FSPF.\|.FRSS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8583

TopFIND

O60344: Endothelin-converting enzyme 2

General Information

1

N-termini

1

C-termini

0

Cleavages

11

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 11 Substrates

N-termini

C-termini

Cleavages

Substrates