TopFIND 4.0

Q9BYF1: Angiotensin-converting enzyme 2

General Information

Protein names
- Angiotensin-converting enzyme 2
- 3.4.17.23
- ACE-related carboxypeptidase
- Angiotensin-converting enzyme homolog
- ACEH
- Metalloprotease MPROT15
- Processed angiotensin-converting enzyme 2
Gene names ACE2
Organism Homo sapiens
Protease Family M02.006
Protease ID M02.006
Chromosome location
UniProt ID Q9BYF1

2

N-termini

2

C-termini

0

Cleavages

15

Substrates

Sequence

        10         20         30         40         50         60 
MSSSSWLLLS LVAVTAAQST IEEQAKTFLD KFNHEAEDLF YQSSLASWNY NTNITEENVQ 
        70         80         90        100        110        120 
NMNNAGDKWS AFLKEQSTLA QMYPLQEIQN LTVKLQLQAL QQNGSSVLSE DKSKRLNTIL 
       130        140        150        160        170        180 
NTMSTIYSTG KVCNPDNPQE CLLLEPGLNE IMANSLDYNE RLWAWESWRS EVGKQLRPLY 
       190        200        210        220        230        240 
EEYVVLKNEM ARANHYEDYG DYWRGDYEVN GVDGYDYSRG QLIEDVEHTF EEIKPLYEHL 
       250        260        270        280        290        300 
HAYVRAKLMN AYPSYISPIG CLPAHLLGDM WGRFWTNLYS LTVPFGQKPN IDVTDAMVDQ 
       310        320        330        340        350        360 
AWDAQRIFKE AEKFFVSVGL PNMTQGFWEN SMLTDPGNVQ KAVCHPTAWD LGKGDFRILM 
       370        380        390        400        410        420 
CTKVTMDDFL TAHHEMGHIQ YDMAYAAQPF LLRNGANEGF HEAVGEIMSL SAATPKHLKS 
       430        440        450        460        470        480 
IGLLSPDFQE DNETEINFLL KQALTIVGTL PFTYMLEKWR WMVFKGEIPK DQWMKKWWEM 
       490        500        510        520        530        540 
KREIVGVVEP VPHDETYCDP ASLFHVSNDY SFIRYYTRTL YQFQFQEALC QAAKHEGPLH 
       550        560        570        580        590        600 
KCDISNSTEA GQKLFNMLRL GKSEPWTLAL ENVVGAKNMN VRPLLNYFEP LFTWLKDQNK 
       610        620        630        640        650        660 
NSFVGWSTDW SPYADQSIKV RISLKSALGD KAYEWNDNEM YLFRSSVAYA MRQYFLKVKN 
       670        680        690        700        710        720 
QMILFGEEDV RVANLKPRIS FNFFVTAPKN VSDIIPRTEV EKAIRMSRSR INDAFRLNDN 
       730        740        750        760        770        780 
SLEFLGIQPT LGPPNQPPVS IWLIVFGVVM GVIVVGIVIL IFTGIRDRKK KNKARSGENP 
       790        800    
YASIDISKGE NNPGFQNTDD VQTSF

Isoforms

- Isoform 2 of Angiotensin-converting enzyme 2

Sequence View

        10         20         30         40         50         60 
MSSSSWLLLS LVAVTAAQST IEEQAKTFLD KFNHEAEDLF YQSSLASWNY NTNITEENVQ 
        70         80         90        100        110        120 
NMNNAGDKWS AFLKEQSTLA QMYPLQEIQN LTVKLQLQAL QQNGSSVLSE DKSKRLNTIL 
       130        140        150        160        170        180 
NTMSTIYSTG KVCNPDNPQE CLLLEPGLNE IMANSLDYNE RLWAWESWRS EVGKQLRPLY 
       190        200        210        220        230        240 
EEYVVLKNEM ARANHYEDYG DYWRGDYEVN GVDGYDYSRG QLIEDVEHTF EEIKPLYEHL 
       250        260        270        280        290        300 
HAYVRAKLMN AYPSYISPIG CLPAHLLGDM WGRFWTNLYS LTVPFGQKPN IDVTDAMVDQ 
       310        320        330        340        350        360 
AWDAQRIFKE AEKFFVSVGL PNMTQGFWEN SMLTDPGNVQ KAVCHPTAWD LGKGDFRILM 
       370        380        390        400        410        420 
CTKVTMDDFL TAHHEMGHIQ YDMAYAAQPF LLRNGANEGF HEAVGEIMSL SAATPKHLKS 
       430        440        450        460        470        480 
IGLLSPDFQE DNETEINFLL KQALTIVGTL PFTYMLEKWR WMVFKGEIPK DQWMKKWWEM 
       490        500        510        520        530        540 
KREIVGVVEP VPHDETYCDP ASLFHVSNDY SFIRYYTRTL YQFQFQEALC QAAKHEGPLH 
       550        560        570        580        590        600 
KCDISNSTEA GQKLFNMLRL GKSEPWTLAL ENVVGAKNMN VRPLLNYFEP LFTWLKDQNK 
       610        620        630        640        650        660 
NSFVGWSTDW SPYADQSIKV RISLKSALGD KAYEWNDNEM YLFRSSVAYA MRQYFLKVKN 
       670        680        690        700        710        720 
QMILFGEEDV RVANLKPRIS FNFFVTAPKN VSDIIPRTEV EKAIRMSRSR INDAFRLNDN 
       730        740        750        760        770        780 
SLEFLGIQPT LGPPNQPPVS IWLIVFGVVM GVIVVGIVIL IFTGIRDRKK KNKARSGENP 
       790        800    
YASIDISKGE NNPGFQNTDD VQTSF



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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 15 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9BYF1-1-unknown MSSSSW... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt66131
    Q9BYF1-18-unknown QSTIEE... 18 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9BYF1-18-unknown QSTIEE... 18 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt111962

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...IRMSRS 708 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...VQTSF 805 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates