Q9UBU3: Appetite-regulating hormone

General Information

Protein names	- Appetite-regulating hormone - Growth hormone secretagogue - Growth hormone-releasing peptide - Motilin-related peptide - Protein M46 - Ghrelin-27 - Ghrelin-28 - Ghrelin - Obestatin
Gene names	GHRL
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UBU3

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

10 20 30 40 50 60
MPSPGTVCSL LLLGMLWLDL AMAGSSFLSP EHQRVQQRKE SKKPPAKLQP RALAGWLRPE
70 80 90 100 110
DGGQAEGAED ELEVRFNAPF DVGIKLSGVQ YQQHSQALGK FLQDILWEEA KEAPADK

Isoforms

- Isoform 2 of Appetite-regulating hormone - Isoform 3 of Appetite-regulating hormone - Isoform 4 of Appetite-regulating hormone - Isoform 5 of Appetite-regulating hormone - Isoform 6 of Appetite-regulating hormone

Sequence View

        10         20         30         40         50         60
MPSPGTVCSL LLLGMLWLDL AMAGSSFLSP EHQRVQQRKE SKKPPAKLQP RALAGWLRPE
        70         80         90        100        110
DGGQAEGAED ELEVRFNAPF DVGIKLSGVQ YQQHSQALGK FLQDILWEEA KEAPADK         10         20         30         40         50         60
MPSPGTVCSL LLLGMLWLDL AMAGSSFLSP EHQRVQQRKE SKKPPAKLQP RALAGWLRPE
        70         80         90        100        110
DGGQAEGAED ELEVRFNAPF DVGIKLSGVQ YQQHSQALGK FLQDILWEEA KEAPADK         10         20         30         40         50         60
MPSPGTVCSL LLLGMLWLDL AMAGSSFLSP EHQRVQQRKE SKKPPAKLQP RALAGWLRPE
        70         80         90        100        110
DGGQAEGAED ELEVRFNAPF DVGIKLSGVQ YQQHSQALGK FLQDILWEEA KEAPADK         10         20         30         40         50         60
MPSPGTVCSL LLLGMLWLDL AMAGSSFLSP EHQRVQQRKE SKKPPAKLQP RALAGWLRPE
        70         80         90        100        110
DGGQAEGAED ELEVRFNAPF DVGIKLSGVQ YQQHSQALGK FLQDILWEEA KEAPADK         10         20         30         40         50         60
MPSPGTVCSL LLLGMLWLDL AMAGSSFLSP EHQRVQQRKE SKKPPAKLQP RALAGWLRPE
        70         80         90        100        110
DGGQAEGAED ELEVRFNAPF DVGIKLSGVQ YQQHSQALGK FLQDILWEEA KEAPADK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9UBU3-1-unknown	MPSPGT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75964
Q9UBU3-1-unknown	MPSPGT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75968
Q9UBU3-51-unknown	RALAGW...	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10
Q9UBU3-51-unknown	RALAGW...	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt138152
Q9UBU3-51-unknown	RALAGW...	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt138225
Q9UBU3-51-unknown	RALAGW...	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139149
Q9UBU3-51-unknown	RALAGW...	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139229

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AKLQPR	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10
...AKLQPR	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122304
...APADK	117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71585
...APADK	117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71584
...APADK	117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71583
...APADK	117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71582

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ACE2_HUMAN	50	LQPR.\|.RALA	inferred from experiment	unknown	MEROPS	Tummino P	Vickers C et al.:Hydrolysis of biological peptid... (M02.006)	11815627,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)