Q99538: Legumain
Protein names | - Legumain - 3.4.22.34 - Asparaginyl endopeptidase - Protease, cysteine 1 |
---|---|
Gene names | LGMN |
Organism | Homo sapiens |
Protease Family | C13.004 |
Protease ID | C13.004 |
Chromosome location | |
UniProt ID | Q99538 |
6
N-termini
8
C-termini
5
Cleavages
59
Substrates
Sequence
10 20 30 40 50 60
MVWKVAVFLS VALGIGAVPI DDPEDGGKHW VVIVAGSNGW YNYRHQADAC HAYQIIHRNG
70 80 90 100 110 120
IPDEQIVVMM YDDIAYSEDN PTPGIVINRP NGTDVYQGVP KDYTGEDVTP QNFLAVLRGD
130 140 150 160 170 180
AEAVKGIGSG KVLKSGPQDH VFIYFTDHGS TGILVFPNED LHVKDLNETI HYMYKHKMYR
190 200 210 220 230 240
KMVFYIEACE SGSMMNHLPD NINVYATTAA NPRESSYACY YDEKRSTYLG DWYSVNWMED
250 260 270 280 290 300
SDVEDLTKET LHKQYHLVKS HTNTSHVMQY GNKTISTMKV MQFQGMKRKA SSPVPLPPVT
310 320 330 340 350 360
HLDLTPSPDV PLTIMKRKLM NTNDLEESRQ LTEEIQRHLD ARHLIEKSVR KIVSLLAASE
370 380 390 400 410 420
AEVEQLLSER APLTGHSCYP EALLHFRTHC FNWHSPTYEY ALRHLYVLVN LCEKPYPLHR
430
IKLSMDHVCL GHY
Isoforms
- Isoform 2 of Legumain - Isoform 3 of LegumainSequence View
10 20 30 40 50 60
MVWKVAVFLS VALGIGAVPI DDPEDGGKHW VVIVAGSNGW YNYRHQADAC HAYQIIHRNG
70 80 90 100 110 120
IPDEQIVVMM YDDIAYSEDN PTPGIVINRP NGTDVYQGVP KDYTGEDVTP QNFLAVLRGD
130 140 150 160 170 180
AEAVKGIGSG KVLKSGPQDH VFIYFTDHGS TGILVFPNED LHVKDLNETI HYMYKHKMYR
190 200 210 220 230 240
KMVFYIEACE SGSMMNHLPD NINVYATTAA NPRESSYACY YDEKRSTYLG DWYSVNWMED
250 260 270 280 290 300
SDVEDLTKET LHKQYHLVKS HTNTSHVMQY GNKTISTMKV MQFQGMKRKA SSPVPLPPVT
310 320 330 340 350 360
HLDLTPSPDV PLTIMKRKLM NTNDLEESRQ LTEEIQRHLD ARHLIEKSVR KIVSLLAASE
370 380 390 400 410 420
AEVEQLLSER APLTGHSCYP EALLHFRTHC FNWHSPTYEY ALRHLYVLVN LCEKPYPLHR
430
IKLSMDHVCL GHY
10 20 30 40 50 60
MVWKVAVFLS VALGIGAVPI DDPEDGGKHW VVIVAGSNGW YNYRHQADAC HAYQIIHRNG
70 80 90 100 110 120
IPDEQIVVMM YDDIAYSEDN PTPGIVINRP NGTDVYQGVP KDYTGEDVTP QNFLAVLRGD
130 140 150 160 170 180
AEAVKGIGSG KVLKSGPQDH VFIYFTDHGS TGILVFPNED LHVKDLNETI HYMYKHKMYR
190 200 210 220 230 240
KMVFYIEACE SGSMMNHLPD NINVYATTAA NPRESSYACY YDEKRSTYLG DWYSVNWMED
250 260 270 280 290 300
SDVEDLTKET LHKQYHLVKS HTNTSHVMQY GNKTISTMKV MQFQGMKRKA SSPVPLPPVT
310 320 330 340 350 360
HLDLTPSPDV PLTIMKRKLM NTNDLEESRQ LTEEIQRHLD ARHLIEKSVR KIVSLLAASE
370 380 390 400 410 420
AEVEQLLSER APLTGHSCYP EALLHFRTHC FNWHSPTYEY ALRHLYVLVN LCEKPYPLHR
430
IKLSMDHVCL GHY
Protein Neighborhood
Domains & Features
6 N-termini - 8 C-termini - 5 Cleavages - 59 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q99538-18-unknown | VPIDDP... | 18 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q99538-22-unknown | DPEDGG... | 22 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16766 | |||
Q99538-26-unknown | GGKHWV... | 26 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16767 | |||
Q99538-304-unknown | LTPSPD... | 304 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16768 | |||
Q99538-310-unknown | VPLTIM... | 310 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16769 | |||
Q99538-324-unknown | DLEESR... | 324 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16770 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...AVPIDD | 21 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16766 | |||
...DDPEDG | 25 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16767 | |||
...YQIIHR | 57 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000452268 | |||
...YQIIHR | 57 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000451797 | |||
...IAYSED | 78 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000450677 | |||
...IAYSED | 78 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000451916 | |||
...HVFIYF | 144 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000450854 | |||
...VTHLDL | 303 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16768 | |||
...TPSPDV | 309 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16769 | |||
...LMNTND | 323 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...LMNTND | 323 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16770 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
LGMN_HUMAN | 21 | PIDD.|.DPED | inferred from experiment | unknown | MEROPS | Watts C | Li DN et al.:Multistep autoactivation of asp... (C13.004) | 12860980, |
LGMN_HUMAN | 25 | PEDG.|.GGKH | inferred from experiment | unknown | MEROPS | Watts C | Li DN et al.:Multistep autoactivation of asp... (C13.004) | 12860980, |
LGMN_HUMAN | 303 | HLDL.|.LTPS | inferred from experiment | unknown | MEROPS | Brandstetter H | Dall E et al.:Activation of legumain involves... (C13.004) | 22232165, |
LGMN_HUMAN | 309 | SPDV.|.VPLT | inferred from experiment | unknown | MEROPS | Brandstetter H | Dall E et al.:Activation of legumain involves... (C13.004) | 22232165, |
LGMN_HUMAN | 323 | NTND.|.DLEE | inferred from experiment | unknown | MEROPS | Merops LGMN_HUMAN -> LGMN_HUMAN @323 |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
HBA_HUMAN | 10 | KTNV.|.VKAA | inferred from experiment | unknown | MEROPS | Kopacek P | Sojka D et al.:IrAE: an asparaginyl endopeptid... (C13.004) | 17336985, |
LGMN_HUMAN | 21 | PIDD.|.DPED | inferred from experiment | unknown | MEROPS | Watts C | Li DN et al.:Multistep autoactivation of asp... (C13.004) | 12860980, |
LGMN_HUMAN | 25 | PEDG.|.GGKH | inferred from experiment | unknown | MEROPS | Watts C | Li DN et al.:Multistep autoactivation of asp... (C13.004) | 12860980, |
HG2A-Isoform3_HUMAN | 27 | SNNE.|.EQLP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16742 | ||
HG2A_HUMAN | 27 | SNNE.|.EQLP | inferred from experiment | unknown | MEROPS | Merops LGMN_HUMAN -> HG2A_HUMAN @27 | ||
HG2A-Isoform2_HUMAN | 27 | SNNE.|.EQLP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16742 | ||
PTMA-Isoform2_HUMAN | 29 | AENG.|.GRDA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16750 | ||
PTMA_HUMAN | 29 | AENG.|.GRDA | inferred from experiment | unknown | MEROPS | Freire M | Sarandeses CS et al.:Prothymosin alpha is processed ... (C13.004) | 12554742, |
PTMA_HUMAN | 36 | PANG.|.GNAE | inferred from experiment | unknown | MEROPS | Freire M | Sarandeses CS et al.:Prothymosin alpha is processed ... (C13.004) | 12554742, |
HBA_HUMAN | 69 | LTNA.|.AVAH | inferred from experiment | unknown | MEROPS | Kopacek P | Sojka D et al.:IrAE: an asparaginyl endopeptid... (C13.004) | 17336985, |
BHMT1_HUMAN | 88 | RGNY.|.YVLE | inferred from experiment | unknown | MEROPS | Seglen PO | Overbye A et al.:Autophagic activity measured in... (C13.004) | 21610319, |
HG2A-Isoform3_HUMAN | 92 | LENL.|.LRMK | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16745 | ||
HG2A_HUMAN | 92 | LENL.|.LRMK | inferred from experiment | unknown | MEROPS | Merops LGMN_HUMAN -> HG2A_HUMAN @92 | ||
HG2A-Isoform2_HUMAN | 92 | LENL.|.LRMK | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16745 | ||
MBP-Isoform6_HUMAN | 93 | FKNI.|.IVTP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16716 | ||
MBP-Isoform5_HUMAN | 93 | FKNI.|.IVTP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16716 | ||
TRFE_HUMAN | 95 | PNNL.|.LKPV | inferred from experiment | unknown | MEROPS | Barrett AJ | Dando PM et al.:Pig kidney legumain: an asparag... (C13.004) | 10215615, |
HBA_HUMAN | 98 | PVNF.|.FKLL | inferred from experiment | unknown | MEROPS | Kopacek P | Sojka D et al.:IrAE: an asparaginyl endopeptid... (C13.004) | 17336985, |
MBP-Isoform4_HUMAN | 119 | FKNI.|.IVTP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16716 | ||
MBP-Isoform3_HUMAN | 119 | FKNI.|.IVTP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16716 | ||
NEUT_HUMAN | 155 | YENK.|.KPRR | inferred from experiment | unknown | MEROPS | Merops LGMN_HUMAN -> NEUT_HUMAN @155 | ||
IGHG1_HUMAN | 169 | VHNA.|.AKTK | inferred from experiment | unknown | MEROPS | Harding FA | Stickler MM et al.:The human G1m1 allotype associa... (C13.004) | 21326320, |
HG2A_HUMAN | 171 | LKNT.|.TMET | inferred from experiment | unknown | MEROPS | Merops LGMN_HUMAN -> HG2A_HUMAN @171 | ||
HG2A-Isoform2_HUMAN | 171 | LKNT.|.TMET | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16748 | ||
IGHG1_HUMAN | 208 | VSNK.|.KALP | inferred from experiment | unknown | MEROPS | Harding FA | Stickler MM et al.:The human G1m1 allotype associa... (C13.004) | 21326320, |
MBP_HUMAN | 226 | FKNI.|.IVTP | inferred from experiment | unknown | MEROPS | Driessen C | Burster T et al.:Cathepsin G, and not the aspara... (S01.133) | 15100291, |
IGHG1_HUMAN | 244 | TKNQ.|.QVSL | inferred from experiment | unknown | MEROPS | Harding FA | Stickler MM et al.:The human G1m1 allotype associa... (C13.004) | 21326320, |
LGMN_HUMAN | 303 | HLDL.|.LTPS | inferred from experiment | unknown | MEROPS | Brandstetter H | Dall E et al.:Activation of legumain involves... (C13.004) | 22232165, |
IGHG1_HUMAN | 304 | QGNV.|.VFSC | inferred from experiment | unknown | MEROPS | Harding FA | Stickler MM et al.:The human G1m1 allotype associa... (C13.004) | 21326320, |
LGMN_HUMAN | 309 | SPDV.|.VPLT | inferred from experiment | unknown | MEROPS | Brandstetter H | Dall E et al.:Activation of legumain involves... (C13.004) | 22232165, |
LGMN_HUMAN | 323 | NTND.|.DLEE | inferred from experiment | unknown | MEROPS | Merops LGMN_HUMAN -> LGMN_HUMAN @323 | ||
TRFE_HUMAN | 529 | PNNK.|.KEGY | inferred from experiment | unknown | MEROPS | Barrett AJ | Dando PM et al.:Pig kidney legumain: an asparag... (C13.004) | 10215615, |
TRFE_HUMAN | 574 | NLNE.|.EKDY | inferred from experiment | unknown | MEROPS | Barrett AJ | Dando PM et al.:Pig kidney legumain: an asparag... (C13.004) | 10215615, |
TRFE_HUMAN | 603 | APNH.|.HAVV | inferred from experiment | unknown | MEROPS | Barrett AJ | Dando PM et al.:Pig kidney legumain: an asparag... (C13.004) | 10215615, |
FINC-Isoform2_HUMAN | 616 | QWNA.|.APQP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16721 | ||
FINC-Isoform9_HUMAN | 631 | QWNA.|.APQP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16721 | ||
FINC-Isoform8_HUMAN | 631 | QWNA.|.APQP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16721 | ||
FINC-Isoform7_HUMAN | 631 | QWNA.|.APQP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16721 | ||
FINC_HUMAN | 631 | QWNA.|.APQP | inferred from experiment | unknown | MEROPS | Ohkubo I | Morita Y et al.:Legumain/asparaginyl endopeptid... (C13.004) | 17350006, |
FINC-Isoform6_HUMAN | 631 | QWNA.|.APQP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16721 | ||
FINC-Isoform5_HUMAN | 631 | QWNA.|.APQP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16721 | ||
FINC-Isoform4_HUMAN | 631 | QWNA.|.APQP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16721 | ||
FINC-Isoform3_HUMAN | 631 | QWNA.|.APQP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16721 | ||
FINC-Isoform17_HUMAN | 631 | QWNA.|.APQP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16721 | ||
FINC-Isoform16_HUMAN | 631 | QWNA.|.APQP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16721 | ||
FINC-Isoform15_HUMAN | 631 | QWNA.|.APQP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16721 | ||
FINC-Isoform14_HUMAN | 631 | QWNA.|.APQP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16721 | ||
FINC-Isoform13_HUMAN | 631 | QWNA.|.APQP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16721 | ||
FINC-Isoform12_HUMAN | 631 | QWNA.|.APQP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16721 | ||
FINC-Isoform11_HUMAN | 631 | QWNA.|.APQP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16721 | ||
FINC-Isoform10_HUMAN | 631 | QWNA.|.APQP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16721 | ||
CO4A3_HUMAN | 1508 | NVND.|.DVCN | inferred from experiment | unknown | MEROPS | Phelps RG | Zou J et al.:Presentation of the Goodpasture... (A01.009) | 17287425, |
CO4A3-Isoform2_HUMAN | 1508 | NVND.|.DVCN | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16757 | ||
CO4A3_HUMAN | 1512 | VCNF.|.FASR | inferred from experiment | unknown | MEROPS | Phelps RG | Zou J et al.:Presentation of the Goodpasture... (A01.009) | 17287425, |
CO4A3-Isoform2_HUMAN | 1512 | VCNF.|.FASR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16759 | ||
CO4A3_HUMAN | 1517 | SRND.|.DYSY | inferred from experiment | unknown | MEROPS | Phelps RG | Zou J et al.:Presentation of the Goodpasture... (A01.009) | 17287425, |
CO4A3-Isoform2_HUMAN | 1517 | SRND.|.DYSY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16761 | ||
CO4A3_HUMAN | 1532 | PMNM.|.MAPI | inferred from experiment | unknown | MEROPS | Phelps RG | Zou J et al.:Presentation of the Goodpasture... (A01.009) | 17287425, |
CO4A3-Isoform2_HUMAN | 1532 | PMNM.|.MAPI | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16763 |