P01857: Immunoglobulin heavy constant gamma 1 {ECO:0000303|PubMed:11340299, ECO:0000303|Ref.11}

General Information

Protein names	- Immunoglobulin heavy constant gamma 1 {ECO:0000303\|PubMed:11340299, ECO:0000303\|Ref.11} - Ig gamma-1 chain C region {ECO:0000305} - Ig gamma-1 chain C region EU {ECO:0000305\|PubMed:5489771, ECO:0000305\|PubMed:5530842} - Ig gamma-1 chain C region KOL {ECO:0000305\|PubMed:6884994} - Ig gamma-1 chain C region NIE {ECO:0000305\|PubMed:826475}
Gene names	IGHG1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P01857

16 N-termini

10 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
        70         80         90        100        110        120
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKKVEP KSCDKTHTCP PCPAPELLGG
       130        140        150        160        170        180
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN
       190        200        210        220        230        240
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE
       250        260        270        280        290        300
LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW
       310        320        330
QQGNVFSCSV MHEALHNHYT QKSLSLSPGK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

16 N-termini - 10 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P01857-1-unknown	ASTKGP...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01857-17-unknown	STSGGT...	17		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01857-18-unknown	TSGGTA...	18		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01857-19-unknown	SGGTAA...	19		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01857-21-unknown	GTAALG...	21		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01857-106-unknown	THTCPP...	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27453
P01857-107-unknown	HTCPPC...	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8646
P01857-116-unknown	ELLGGP...	116	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19987
P01857-116-unknown	ELLGGP...	116	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23664
P01857-117-unknown	LLGGPS...	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4750
P01857-118-unknown	LGGPSV...	118	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23960
P01857-118-unknown	LGGPSV...	118	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27384
P01857-170-unknown	AKTKPR...	170	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16712
P01857-204-unknown	CKVSNK...	204		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01857-209-unknown	KALPAP...	209	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16713
P01857-209-unknown	KALPAP...	209		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01857-210-unknown	ALPAPI...	210		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01857-245-unknown	QVSLTC...	245	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16714
P01857-305-unknown	VFSCSV...	305	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16715

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KSCDKT	105	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27453
...SCDKTH	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8646
...PCPAPE	115	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19987
...PCPAPE	115	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23664
...CPAPEL	116	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4750
...PAPELL	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23960
...PAPELL	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27384
...VEVHNA	169	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16712
...CKVSNK	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16713
...ELTKNQ	244	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16714
...WQQGNV	304	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16715
...LSPGK	330	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PLMN_HUMAN	105	CDKT.\|.THTC	inferred from experiment	unknown	MEROPS	Jordan RE	Ryan MH et al.:Proteolysis of purified IgGs by... (S01.133)	18157932,
ELNE_HUMAN	106	DKTH.\|.HTCP	inferred from experiment	unknown	MEROPS	Jordan RE	Ryan MH et al.:Proteolysis of purified IgGs by... (S01.133)	18157932,
MMP12_HUMAN	115	PAPE.\|.ELLG	inferred from experiment	unknown	MEROPS	Jordan RE	Ryan MH et al.:Proteolysis of purified IgGs by... (S01.133)	18157932,
MMP3_HUMAN	115	PAPE.\|.ELLG	inferred from experiment	unknown	MEROPS	Thorpe R	Gearing AJ et al.:Selective cleavage of human IgG... (M10.005)	11841844,
CATG_HUMAN	116	APEL.\|.LLGG	inferred from experiment	unknown	MEROPS	Jordan RE	Ryan MH et al.:Proteolysis of purified IgGs by... (S01.133)	18157932,
MMP7_HUMAN	117	PELL.\|.LGGP	inferred from experiment	unknown	MEROPS	Thorpe R	Gearing AJ et al.:Selective cleavage of human IgG... (M10.005)	11841844,
PEPA4_HUMAN	117	PELL.\|.LGGP	inferred from experiment	unknown	MEROPS	Jordan RE	Ryan MH et al.:Proteolysis of purified IgGs by... (S01.133)	18157932,
LGMN_HUMAN	169	VHNA.\|.AKTK	inferred from experiment	unknown	MEROPS	Harding FA	Stickler MM et al.:The human G1m1 allotype associa... (C13.004)	21326320,
LGMN_HUMAN	208	VSNK.\|.KALP	inferred from experiment	unknown	MEROPS	Harding FA	Stickler MM et al.:The human G1m1 allotype associa... (C13.004)	21326320,
LGMN_HUMAN	244	TKNQ.\|.QVSL	inferred from experiment	unknown	MEROPS	Harding FA	Stickler MM et al.:The human G1m1 allotype associa... (C13.004)	21326320,
LGMN_HUMAN	304	QGNV.\|.VFSC	inferred from experiment	unknown	MEROPS	Harding FA	Stickler MM et al.:The human G1m1 allotype associa... (C13.004)	21326320,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)