P0DJD7: Pepsin A-4

General Information

Protein names	- Pepsin A-4 - 3.4.23.1 - Pepsinogen-4
Gene names	PGA4
Organism	Homo sapiens
Protease Family	A01.070
Protease ID	A01.070
Chromosome location
UniProt ID	P0DJD7

4 N-termini

4 C-termini

3 Cleavages

4 Substrates

Sequence

        10         20         30         40         50         60
MKWLLLLGLV ALSECIMYKV PLIRKKSLRR TLSERGLLKD FLKKHNLNPA RKYFPQWEAP
        70         80         90        100        110        120
TLVDEQPLEN YLDMEYFGTI GIGTPAQDFT VVFDTGSSNL WVPSVYCSSL ACTNHNRFNP
       130        140        150        160        170        180
EDSSTYQSTS ETVSITYGTG SMTGILGYDT VQVGGISDTN QIFGLSETEP GSFLYYAPFD
       190        200        210        220        230        240
GILGLAYPSI SSSGATPVFD NIWNQGLVSQ DLFSVYLSAD DQSGSVVIFG GIDSSYYTGS
       250        260        270        280        290        300
LNWVPVTVEG YWQITVDSIT MNGEAIACAE GCQAIVDTGT SLLTGPTSPI ANIQSDIGAS
       310        320        330        340        350        360
ENSDGDMVVS CSAISSLPDI VFTINGVQYP VPPSAYILQS EGSCISGFQG MNLPTESGEL
       370        380
WILGDVFIRQ YFTVFDRANN QVGLAPVA

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 3 Cleavages - 4 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P0DJD7-39-unknown	KDFLKK...	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27385
P0DJD7-41-unknown	FLKKHN...	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27386
P0DJD7-63-unknown	VDEQPL...	63	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P0DJD7-63-unknown	VDEQPL...	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27387
P0DJD7-261-unknown	MNGEAI...	261	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000443623

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ERGLLK	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27385
...GLLKDF	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27386
...EAPTLV	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27387
...LAPVA	388	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PEPA4_HUMAN	38	GLLK.\|.KDFL	inferred from experiment	unknown	MEROPS	Takahashi K	Athauda SB et al.:A comparative study on the NH2-... (A01.070)	2515193,
PEPA4_HUMAN	40	LKDF.\|.FLKK	inferred from experiment	unknown	MEROPS	Takahashi K	Athauda SB et al.:A comparative study on the NH2-... (A01.070)	2515193,
PEPA4_HUMAN	62	PTLV.\|.VDEQ	inferred from experiment	unknown	MEROPS	Takahashi K	Athauda SB et al.:A comparative study on the NH2-... (A01.070)	2515193,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PEPA4_HUMAN	38	GLLK.\|.KDFL	inferred from experiment	unknown	MEROPS	Takahashi K	Athauda SB et al.:A comparative study on the NH2-... (A01.070)	2515193,
PEPA4_HUMAN	40	LKDF.\|.FLKK	inferred from experiment	unknown	MEROPS	Takahashi K	Athauda SB et al.:A comparative study on the NH2-... (A01.070)	2515193,
PEPA4_HUMAN	62	PTLV.\|.VDEQ	inferred from experiment	unknown	MEROPS	Takahashi K	Athauda SB et al.:A comparative study on the NH2-... (A01.070)	2515193,
IGHG1_HUMAN	117	PELL.\|.LGGP	inferred from experiment	unknown	MEROPS	Jordan RE	Ryan MH et al.:Proteolysis of purified IgGs by... (S01.133)	18157932,