TopFIND 4.0

P39900: Macrophage metalloelastase

General Information

Protein names
- Macrophage metalloelastase
- MME
- 3.4.24.65
- Macrophage elastase
- ME
- hME
- Matrix metalloproteinase-12
- MMP-12
Gene names MMP12
Organism Homo sapiens
Protease Family M10.009
Protease ID M10.009
Chromosome location
UniProt ID P39900

2

N-termini

1

C-termini

0

Cleavages

1336

Substrates

Sequence

        10         20         30         40         50         60 
MKFLLILLLQ ATASGALPLN SSTSLEKNNV LFGERYLEKF YGLEINKLPV TKMKYSGNLM 
        70         80         90        100        110        120 
KEKIQEMQHF LGLKVTGQLD TSTLEMMHAP RCGVPDVHHF REMPGGPVWR KHYITYRINN 
       130        140        150        160        170        180 
YTPDMNREDV DYAIRKAFQV WSNVTPLKFS KINTGMADIL VVFARGAHGD FHAFDGKGGI 
       190        200        210        220        230        240 
LAHAFGPGSG IGGDAHFDED EFWTTHSGGT NLFLTAVHEI GHSLGLGHSS DPKAVMFPTY 
       250        260        270        280        290        300 
KYVDINTFRL SADDIRGIQS LYGDPKENQR LPNPDNSEPA LCDPNLSFDA VTTVGNKIFF 
       310        320        330        340        350        360 
FKDRFFWLKV SERPKTSVNL ISSLWPTLPS GIEAAYEIEA RNQVFLFKDD KYWLISNLRP 
       370        380        390        400        410        420 
EPNYPKSIHS FGFPNFVKKI DAAVFNPRFY RTYFFVDNQY WRYDERRQMM DPGYPKLITK 
       430        440        450        460        470    
NFQGIGPKID AVFYSKNKYY YFFQGSNQFE YDFLLQRITK TLKSNSWFGC 

Isoforms



Sequence View



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(REFRESH)

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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 1336 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...SWFGC 470 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates