TopFIND 4.0

P13500: C-C motif chemokine 2

General Information

Protein names	- C-C motif chemokine 2 - HC11 - Monocyte chemoattractant protein 1 - Monocyte chemotactic and activating factor - MCAF - Monocyte chemotactic protein 1 - MCP-1 - Monocyte secretory protein JE - Small-inducible cytokine A2
Gene names	CCL2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P13500

5

N-termini

4

C-termini

12

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MKVSAALLCL LLIAATFIPQ GLAQPDAINA PVTCCYNFTN RKISVQRLAS YRRITSSKCP
70 80 90
KEAVIFKTIV AKEICADPKQ KWVQDSMDHL DKQTQTPKT

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 12 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P13500-5-unknown	AALLCL...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34838
P13500-5-unknown	AALLCL...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34856
P13500-5-unknown	AALLCL...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34880
P13500-5-unknown	AALLCL...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34942
P13500-5-unknown	AALLCL...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34970
P13500-5-unknown	AALLCL...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC35001
P13500-5-unknown	AALLCL...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC35018
P13500-5-unknown	AALLCL...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC35039
P13500-24-Pyrrolidone carboxylic acid	QPDAIN...	24	pyrrolidone carboxylic acid-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P13500-26-unknown	DAINAP...	26		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8485
P13500-28-unknown	INAPVT...	28		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23870
P13500-28-unknown	INAPVT...	28		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21743
P13500-68-unknown	TIVAKE...	68		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34971

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...GLAQPD	25	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8485
	...AQPDAI	27	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23870
	...AQPDAI	27	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21743
	...AVIFKT	67	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34971
	...QTPKT	99	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP1_HUMAN	4	KVSA.\|.AALL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP12_HUMAN	4	KVSA.\|.AALL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP13_HUMAN	4	KVSA.\|.AALL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP3_HUMAN	4	KVSA.\|.AALL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP7_HUMAN	4	KVSA.\|.AALL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP8_HUMAN	4	KVSA.\|.AALL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP9_HUMAN	4	KVSA.\|.AALL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP25_HUMAN	4	KVSA.\|.AALL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012B	22367194,
DPP4_HUMAN	25	AQPD.\|.DAIN	inferred from experiment	unknown	MEROPS	Yoshikawa M	Kumagai Y et al.:Enzymatic properties of dipepti... (S09.003)	10639438,
MMP3_HUMAN	27	PDAI.\|.INAP	inferred from experiment	unknown	MEROPS	Overall CM	McQuibban GA et al.:Matrix metalloproteinase proces... (M10.013)	12149192,
MMP1_HUMAN	27	PDAI.\|.INAP	inferred from experiment	unknown	MEROPS	Overall CM	McQuibban GA et al.:Matrix metalloproteinase proces... (M10.013)	12149192,
MMP7_HUMAN	67	IFKT.\|.TIVA		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)