Q9NPA2: Matrix metalloproteinase-25
| Protein names | - Matrix metalloproteinase-25 - MMP-25 - 3.4.24.- - Leukolysin - Membrane-type matrix metalloproteinase 6 - MT-MMP 6 - MTMMP6 - Membrane-type-6 matrix metalloproteinase - MT6-MMP - MT6MMP |
|---|---|
| Gene names | MMP25 |
| Organism | Homo sapiens |
| Protease Family | M10.024 |
| Protease ID | M10.024 |
| Chromosome location | |
| UniProt ID | Q9NPA2 |
2
N-termini
2
C-termini
2
Cleavages
71
Substrates
Sequence
10 20 30 40 50 60
MRLRLRLLAL LLLLLAPPAR APKPSAQDVS LGVDWLTRYG YLPPPHPAQA QLQSPEKLRD
70 80 90 100 110 120
AIKVMQRFAG LPETGRMDPG TVATMRKPRC SLPDVLGVAG LVRRRRRYAL SGSVWKKRTL
130 140 150 160 170 180
TWRVRSFPQS SQLSQETVRV LMSYALMAWG MESGLTFHEV DSPQGQEPDI LIDFARAFHQ
190 200 210 220 230 240
DSYPFDGLGG TLAHAFFPGE HPISGDTHFD DEETWTFGSK DGEGTDLFAV AVHEFGHALG
250 260 270 280 290 300
LGHSSAPNSI MRPFYQGPVG DPDKYRLSQD DRDGLQQLYG KAPQTPYDKP TRKPLAPPPQ
310 320 330 340 350 360
PPASPTHSPS FPIPDRCEGN FDAIANIRGE TFFFKGPWFW RLQPSGQLVS PRPARLHRFW
370 380 390 400 410 420
EGLPAQVRVV QAAYARHRDG RILLFSGPQF WVFQDRQLEG GARPLTELGL PPGEEVDAVF
430 440 450 460 470 480
SWPQNGKTYL VRGRQYWRYD EAAARPDPGY PRDLSLWEGA PPSPDDVTVS NAGDTYFFKG
490 500 510 520 530 540
AHYWRFPKNS IKTEPDAPQP MGPNWLDCPA PSSGPRAPRP PKATPVSETC DCQCELNQAA
550 560
GRWPAPIPLL LLPLLVGGVA SR
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
2 N-termini - 2 C-termini - 2 Cleavages - 71 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q9NPA2-22-unknown | PKPSAQ... | 22 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q9NPA2-108-unknown | YALSGS... | 108 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q9NPA2-108-unknown | YALSGS... | 108 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26660 | |||
| Q9NPA2-108-unknown | YALSGS... | 108 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9831 | |||
| Q9NPA2-108-unknown | YALSGS... | 108 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...RRRRRY | 107 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26660 | |||
| ...RRRRRY | 107 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9831 | |||
| ...ELNQAA | 539 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| NEC2_HUMAN | 107 | RRRY.|.YALS | inferred from experiment | unknown | MEROPS | Strongin AY | Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) | 18505722, |
| FURIN_HUMAN | 107 | RRRY.|.YALS | inferred from experiment | unknown | MEROPS | Strongin AY | Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) | 18505722, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| CXCL5_MOUSE | 4 | SLQL.|.LRSS | MS other | Overall Lab | recMMP-Chemokine_AStarr2012B | 22367194, | ||
| CXCL2_HUMAN | 4 | ARAT.|.TLSA | MS other | Overall Lab | recMMP-Chemokine_AStarr2012B | 22367194, | ||
| SDF1_HUMAN | 4 | NAKV.|.VVVV | MS other | Overall Lab | recMMP-Chemokine_AStarr2012B | 22367194, | ||
| CCL7_HUMAN | 4 | KASA.|.AALL | MS other | Overall Lab | recMMP-Chemokine_AStarr2012B | 22367194, | ||
| CCL2_HUMAN | 4 | KVSA.|.AALL | MS other | Overall Lab | recMMP-Chemokine_AStarr2012B | 22367194, | ||
| CCL16_HUMAN | 4 | KVSE.|.EAAL | MS other | Overall Lab | recMMP-Chemokine_AStarr2012B | 22367194, | ||
| CCL13_HUMAN | 4 | KVSA.|.AVLL | MS other | Overall Lab | recMMP-Chemokine_AStarr2012B | 22367194, | ||
| CCL4_HUMAN | 6 | CVTV.|.VLSL | MS other | Overall Lab | recMMP-Chemokine_AStarr2012B | 22367194, | ||
| CXCL5_HUMAN | 7 | SSRA.|.AARV | MS other | Overall Lab | recMMP-Chemokine_AStarr2012B | 22367194, | ||
| CXCL5_MOUSE | 9 | SSAR.|.RIPS | MS other | Overall Lab | recMMP-Chemokine_AStarr2012B | 22367194, | ||
| CCL23_HUMAN | 10 | LSCL.|.LMLV | MS other | Overall Lab | recMMP-Chemokine_AStarr2012B | 22367194, | ||
| MBP-Isoform6_HUMAN | 15 | SKYL.|.LATA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21827 | ||
| MBP-Isoform5_HUMAN | 15 | SKYL.|.LATA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21827 | ||
| MBP-Isoform4_HUMAN | 15 | SKYL.|.LATA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21827 | ||
| MBP-Isoform3_HUMAN | 15 | SKYL.|.LATA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21827 | ||
| MMP2-Isoform3_HUMAN | 16 | SCNL.|.LFVL | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21862 | ||
| CCL23-Isoform2_HUMAN | 20 | GSQA.|.ARVT | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC35035 | ||
| CCL23_HUMAN | 20 | GSQA.|.ARVT | MS other | Overall Lab | recMMP-Chemokine_AStarr2012B | 22367194, | ||
| CCL15_HUMAN | 24 | QFIN.|.NDAE | MS other | Overall Lab | recMMP-Chemokine_AStarr2012B | 22367194, | ||
| CCL23-Isoform2_HUMAN | 25 | VTKD.|.DAET | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC35037 | ||
| CCL23_HUMAN | 25 | VTKD.|.DAET | MS other | Overall Lab | recMMP-Chemokine_AStarr2012B | 22367194, | ||
| CCL15_HUMAN | 26 | INDA.|.AETE | MS other | Overall Lab | recMMP-Chemokine_AStarr2012B | 22367194, | ||
| CXCL6_HUMAN | 28 | LLLT.|.TPPG | MS other | Overall Lab | recMMP-Chemokine_AStarr2012B | 22367194, | ||
| MMP2-Isoform2_HUMAN | 33 | VANY.|.YNFF | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21864 | ||
| MMP2-Isoform3_HUMAN | 59 | VANY.|.YNFF | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21864 | ||
| MMP2_HUMAN | 66 | SCNL.|.LFVL | inferred from experiment | unknown | MEROPS | Pei D | Nie J et al.:Direct activation of pro-matrix... (M10.024) | 14583471, |
| CCL13_HUMAN | 72 | GKEI.|.ICAD | MS other | Overall Lab | recMMP-Chemokine_AStarr2012B | 22367194, | ||
| MBP-Isoform6_HUMAN | 90 | VHFF.|.FKNI | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21833 | ||
| MBP-Isoform5_HUMAN | 90 | VHFF.|.FKNI | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21833 | ||
| CXCL9_HUMAN | 90 | KWEK.|.KQVS | MS other | Overall Lab | recMMP-Chemokine_AStarr2012B | 22367194, | ||
| MBP-Isoform5_HUMAN | 102 | PPPS.|.SQGK | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21838 | ||
| UPAR_HUMAN | 108 | AVTY.|.YSRS | inferred from experiment | unknown | MEROPS | Sidenius N | Andolfo A et al.:Metalloproteases cleave the uro... (S01.131) | 12195704, |
| UPAR-Isoform3_HUMAN | 108 | AVTY.|.YSRS | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21867 | ||
| UPAR-Isoform2_HUMAN | 108 | AVTY.|.YSRS | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21867 | ||
| UPAR_HUMAN | 109 | VTYS.|.SRSR | inferred from experiment | unknown | MEROPS | Sidenius N | Andolfo A et al.:Metalloproteases cleave the uro... (S01.131) | 12195704, |
| MBP-Isoform5_HUMAN | 109 | GRGL.|.LSLS | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21841 | ||
| MMP2_HUMAN | 109 | VANY.|.YNFF | inferred from experiment | unknown | MEROPS | Pei D | Nie J et al.:Direct activation of pro-matrix... (M10.024) | 14583471, |
| UPAR-Isoform3_HUMAN | 109 | VTYS.|.SRSR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21870 | ||
| UPAR-Isoform2_HUMAN | 109 | VTYS.|.SRSR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21870 | ||
| UPAR_HUMAN | 111 | YSRS.|.SRYL | inferred from experiment | unknown | MEROPS | Sidenius N | Andolfo A et al.:Metalloproteases cleave the uro... (S01.131) | 12195704, |
| MBP-Isoform5_HUMAN | 111 | GLSL.|.LSRF | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21844 | ||
| UPAR-Isoform3_HUMAN | 111 | YSRS.|.SRYL | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21873 | ||
| UPAR-Isoform2_HUMAN | 111 | YSRS.|.SRYL | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21873 | ||
| MBP-Isoform4_HUMAN | 116 | VHFF.|.FKNI | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21833 | ||
| MBP-Isoform3_HUMAN | 116 | VHFF.|.FKNI | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21833 | ||
| MBP-Isoform6_HUMAN | 123 | ASDY.|.YKSA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21847 | ||
| MBP-Isoform3_HUMAN | 128 | PPPS.|.SQGK | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21838 | ||
| MBP-Isoform5_HUMAN | 134 | ASDY.|.YKSA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21847 | ||
| MBP-Isoform3_HUMAN | 135 | GRGL.|.LSLS | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21841 | ||
| MBP-Isoform3_HUMAN | 137 | GLSL.|.LSRF | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21844 | ||
| MBP-Isoform6_HUMAN | 142 | LSKI.|.IFKL | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21852 | ||
| MBP-Isoform2_HUMAN | 148 | SKYL.|.LATA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21827 | ||
| MBP_HUMAN | 148 | SKYL.|.LATA | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
| MBP-Isoform4_HUMAN | 149 | ASDY.|.YKSA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21847 | ||
| MBP-Isoform5_HUMAN | 153 | LSKI.|.IFKL | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21852 | ||
| MBP-Isoform6_HUMAN | 158 | PMAR.|.RR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21857 | ||
| MBP-Isoform3_HUMAN | 160 | ASDY.|.YKSA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21847 | ||
| MBP-Isoform4_HUMAN | 168 | LSKI.|.IFKL | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21852 | ||
| MBP-Isoform5_HUMAN | 169 | PMAR.|.RR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21857 | ||
| MBP-Isoform3_HUMAN | 179 | LSKI.|.IFKL | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21852 | ||
| MBP-Isoform4_HUMAN | 184 | PMAR.|.RR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21857 | ||
| MBP-Isoform3_HUMAN | 195 | PMAR.|.RR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC21857 | ||
| MBP_HUMAN | 223 | VHFF.|.FKNI | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
| MBP_HUMAN | 235 | PPPS.|.SQGK | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
| MBP_HUMAN | 242 | GRGL.|.LSLS | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
| MBP_HUMAN | 244 | GLSL.|.LSRF | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
| MBP_HUMAN | 267 | ASDY.|.YKSA | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
| MBP_HUMAN | 286 | LSKI.|.IFKL | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
| MBP_HUMAN | 302 | PMAR.|.RR | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
| A1AT_HUMAN | 376 | AMFL.|.LEAI | inferred from experiment | unknown | MEROPS | Pei D | Nie J et al.:Rapid inactivation of alpha-1-p... (M10.024) | 15149845, |
| A1AT_HUMAN | 381 | AIPM.|.MSIP | inferred from experiment | unknown | MEROPS | Pei D | Nie J et al.:Rapid inactivation of alpha-1-p... (M10.024) | 15149845, |