TopFIND 4.0

P80162: C-X-C motif chemokine 6

General Information

Protein names	- C-X-C motif chemokine 6 - Chemokine alpha 3 - CKA-3 - Granulocyte chemotactic protein 2 - GCP-2 - Small-inducible cytokine B6 - Small-inducible cytokine B6, N-processed variant 1 - Small-inducible cytokine B6, N-processed variant 2 - Small-inducible cytokine B6, N-processed variant 3
Gene names	CXCL6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P80162

7

N-termini

6

C-termini

7

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MSLPSSRAAR VPGPSGSLCA LLALLLLLTP PGPLASAGPV SAVLTELRCT CLRVTLRVNP
70 80 90 100 110
KTIGKLQVFP AGPQCSKVEV VASLKNGKQV CLDPEAPFLK KVIQKILDSG NKKN

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 6 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P80162-29-unknown	TPPGPL...	29		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC35028
P80162-38-unknown	GPVSAV...	38		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P80162-40-unknown	VSAVLT...	40		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P80162-40-unknown	VSAVLT...	40		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8501
P80162-42-unknown	AVLTEL...	42		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26456
P80162-43-unknown	VLTELR...	43		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P80162-43-unknown	VLTELR...	43		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25100
P80162-43-unknown	VLTELR...	43		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26457
P80162-44-unknown	LTELRC...	44		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25101
P80162-44-unknown	LTELRC...	44		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26458
P80162-46-unknown	ELRCTC...	46		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...LLLLLT	28	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC35028
	...ASAGPV	39	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8501
	...AGPVSA	41	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26456
	...GPVSAV	42	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25100
	...GPVSAV	42	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26457
	...PVSAVL	43	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25101
	...PVSAVL	43	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26458
	...GNKKN	114	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP25_HUMAN	28	LLLT.\|.TPPG		MS other		Overall Lab	recMMP-Chemokine_AStarr2012B	22367194,
DPP4_HUMAN	39	AGPV.\|.VSAV	inferred from experiment	unknown	MEROPS	Gorrell MD	Ajami K et al.:Stromal cell-derived factors 1a... (S09.003)	18275857,
MMP9_HUMAN	41	PVSA.\|.AVLT	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,
MMP8_HUMAN	42	VSAV.\|.VLTE	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,
MMP9_HUMAN	42	VSAV.\|.VLTE	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,
MMP8_HUMAN	43	SAVL.\|.LTEL	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,
MMP9_HUMAN	43	SAVL.\|.LTEL	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)