Q03405: Urokinase plasminogen activator surface receptor

General Information

Protein names	- Urokinase plasminogen activator surface receptor - U-PAR - uPAR - Monocyte activation antigen Mo3 - CD87
Gene names	PLAUR
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q03405

10 N-termini

10 C-termini

21 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Urokinase plasminogen activator surface receptor - Isoform 3 of Urokinase plasminogen activator surface receptor

Sequence View

        10         20         30         40         50         60
MGHPPLLPLL LLLHTCVPAS WGLRCMQCKT NGDCRVEECA LGQDLCRTTI VRLWEEGEEL
        70         80         90        100        110        120
ELVEKSCTHS EKTNRTLSYR TGLKITSLTE VVCGLDLCNQ GNSGRAVTYS RSRYLECISC
       130        140        150        160        170        180
GSSDMSCERG RHQSLQCRSP EEQCLDVVTH WIQEGEEGRP KDDRHLRGCG YLPGCPGSNG
       190        200        210        220        230        240
FHNNDTFHFL KCCNTTKCNE GPILELENLP QNGRQCYSCK GNSTHGCSSE ETFLIDCRGP
       250        260        270        280        290        300
MNQCLVATGT HEPKNQSYMV RGCATASMCQ HAHLGDAFSM NHIDVSCCTK SGCNHPDLDV
       310        320        330
QYRSGAAPQP GPAHLSLTIT LLMTARLWGG TLLWT         10         20         30         40         50         60
MGHPPLLPLL LLLHTCVPAS WGLRCMQCKT NGDCRVEECA LGQDLCRTTI VRLWEEGEEL
        70         80         90        100        110        120
ELVEKSCTHS EKTNRTLSYR TGLKITSLTE VVCGLDLCNQ GNSGRAVTYS RSRYLECISC
       130        140        150        160        170        180
GSSDMSCERG RHQSLQCRSP EEQCLDVVTH WIQEGEEGRP KDDRHLRGCG YLPGCPGSNG
       190        200        210        220        230        240
FHNNDTFHFL KCCNTTKCNE GPILELENLP QNGRQCYSCK GNSTHGCSSE ETFLIDCRGP
       250        260        270        280        290        300
MNQCLVATGT HEPKNQSYMV RGCATASMCQ HAHLGDAFSM NHIDVSCCTK SGCNHPDLDV
       310        320        330
QYRSGAAPQP GPAHLSLTIT LLMTARLWGG TLLWT

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 10 C-termini - 21 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q03405-1-unknown	MGHPPL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt93932
Q03405-1-unknown	MGHPPL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt93933
Q03405-23-unknown	LRCMQC...	23	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q03405-23-unknown	LRCMQC...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113337
Q03405-23-unknown	LRCMQC...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113338
Q03405-106-unknown	AVTYSR...	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32088
Q03405-106-unknown	AVTYSR...	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31852
Q03405-106-unknown	AVTYSR...	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27594
Q03405-106-unknown	AVTYSR...	106	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142687
Q03405-106-unknown	AVTYSR...	106	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142689
Q03405-108-unknown	TYSRSR...	108	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9491
Q03405-108-unknown	TYSRSR...	108	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142796
Q03405-108-unknown	TYSRSR...	108	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142798
Q03405-109-unknown	YSRSRY...	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21275
Q03405-109-unknown	YSRSRY...	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21867
Q03405-109-unknown	YSRSRY...	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23941
Q03405-109-unknown	YSRSRY...	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21702
Q03405-109-unknown	YSRSRY...	109	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142864
Q03405-109-unknown	YSRSRY...	109	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142865
Q03405-110-unknown	SRSRYL...	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4924
Q03405-110-unknown	SRSRYL...	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21870
Q03405-110-unknown	SRSRYL...	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21705
Q03405-110-unknown	SRSRYL...	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16368
Q03405-110-unknown	SRSRYL...	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142927
Q03405-110-unknown	SRSRYL...	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142928
Q03405-111-unknown	RSRYLE...	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21708
Q03405-111-unknown	RSRYLE...	111	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143028
Q03405-111-unknown	RSRYLE...	111	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143029
Q03405-112-unknown	SRYLEC...	112	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32091
Q03405-112-unknown	SRYLEC...	112	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31855
Q03405-112-unknown	SRYLEC...	112	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21873
Q03405-112-unknown	SRYLEC...	112	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27597
Q03405-112-unknown	SRYLEC...	112	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21711
Q03405-112-unknown	SRYLEC...	112	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16371
Q03405-112-unknown	SRYLEC...	112	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143055
Q03405-112-unknown	SRYLEC...	112	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143056
Q03405-115-unknown	LECISC...	115	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4927
Q03405-115-unknown	LECISC...	115	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143232
Q03405-115-unknown	LECISC...	115	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143233
Q03405-304-unknown	SGAAPQ...	304	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16374
Q03405-304-unknown	SGAAPQ...	304	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148789

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GNSGRA	105	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32088
...GNSGRA	105	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31852
...GNSGRA	105	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27594
...GNSGRA	105	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125887
...GNSGRA	105	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125889
...SGRAVT	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9491
...SGRAVT	107	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126001
...SGRAVT	107	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126003
...GRAVTY	108	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21275
...GRAVTY	108	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21867
...GRAVTY	108	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23941
...GRAVTY	108	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21702
...GRAVTY	108	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126073
...GRAVTY	108	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126074
...RAVTYS	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4924
...RAVTYS	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21870
...RAVTYS	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21705
...RAVTYS	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16368
...RAVTYS	109	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126137
...RAVTYS	109	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126138
...AVTYSR	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21708
...AVTYSR	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126245
...AVTYSR	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126246
...VTYSRS	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32091
...VTYSRS	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31855
...VTYSRS	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21873
...VTYSRS	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27597
...VTYSRS	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21711
...VTYSRS	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16371
...VTYSRS	111	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126275
...VTYSRS	111	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126276
...SRSRYL	114	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4927
...SRSRYL	114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126458
...SRSRYL	114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126459
...DVQYRS	303	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16374
...DVQYRS	303	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132165
...QYRSGA	305	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QYRSGA	305	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92322
...TLLWT	335	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89551

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
UROK_HUMAN	105	SGRA.\|.AVTY	inferred from experiment	unknown	MEROPS	Sidenius N	Andolfo A et al.:Metalloproteases cleave the uro... (S01.131)	12195704,
TM11D_HUMAN	105	SGRA.\|.AVTY	inferred from experiment	unknown	MEROPS	Pidard D	Beaufort N et al.:The human airway trypsin-like p... (S01.047)	17237151,
PLMN_HUMAN	105	SGRA.\|.AVTY	inferred from experiment	unknown	MEROPS	Sidenius N	Andolfo A et al.:Metalloproteases cleave the uro... (S01.131)	12195704,
ELNE_HUMAN	107	RAVT.\|.TYSR	inferred from experiment	unknown	MEROPS	Sidenius N	Andolfo A et al.:Metalloproteases cleave the uro... (S01.131)	12195704,
MMP12_HUMAN	108	AVTY.\|.YSRS	inferred from experiment	unknown	MEROPS	Sidenius N	Andolfo A et al.:Metalloproteases cleave the uro... (S01.131)	12195704,
MMP25_HUMAN	108	AVTY.\|.YSRS	inferred from experiment	unknown	MEROPS	Sidenius N	Andolfo A et al.:Metalloproteases cleave the uro... (S01.131)	12195704,
MMP3_HUMAN	108	AVTY.\|.YSRS	inferred from experiment	unknown	MEROPS	Sidenius N	Andolfo A et al.:Metalloproteases cleave the uro... (S01.131)	12195704,
MMP19_HUMAN	108	AVTY.\|.YSRS	inferred from experiment	unknown	MEROPS	Sidenius N	Andolfo A et al.:Metalloproteases cleave the uro... (S01.131)	12195704,
CATG_HUMAN	109	VTYS.\|.SRSR	inferred from experiment	unknown	MEROPS	Pidard D	Beaufort N et al.:Proteolytic regulation of the u... (S01.133)	14688365,
MMP25_HUMAN	109	VTYS.\|.SRSR	inferred from experiment	unknown	MEROPS	Sidenius N	Andolfo A et al.:Metalloproteases cleave the uro... (S01.131)	12195704,
MMP19_HUMAN	109	VTYS.\|.SRSR	inferred from experiment	unknown	MEROPS	Sidenius N	Andolfo A et al.:Metalloproteases cleave the uro... (S01.131)	12195704,
KLK4_HUMAN	109	VTYS.\|.SRSR	inferred from experiment	unknown	MEROPS	Magdolen V	Beaufort N et al.:Interplay of human tissue kalli... (S01.251)	16497155,
MMP19_HUMAN	110	TYSR.\|.RSRY	inferred from experiment	unknown	MEROPS	Sidenius N	Andolfo A et al.:Metalloproteases cleave the uro... (S01.131)	12195704,
UROK_HUMAN	111	YSRS.\|.SRYL	inferred from experiment	unknown	MEROPS	Sidenius N	Andolfo A et al.:Metalloproteases cleave the uro... (S01.131)	12195704,
TM11D_HUMAN	111	YSRS.\|.SRYL	inferred from experiment	unknown	MEROPS	Pidard D	Beaufort N et al.:The human airway trypsin-like p... (S01.047)	17237151,
MMP25_HUMAN	111	YSRS.\|.SRYL	inferred from experiment	unknown	MEROPS	Sidenius N	Andolfo A et al.:Metalloproteases cleave the uro... (S01.131)	12195704,
PLMN_HUMAN	111	YSRS.\|.SRYL	inferred from experiment	unknown	MEROPS	Sidenius N	Andolfo A et al.:Metalloproteases cleave the uro... (S01.131)	12195704,
MMP19_HUMAN	111	YSRS.\|.SRYL	inferred from experiment	unknown	MEROPS	Sidenius N	Andolfo A et al.:Metalloproteases cleave the uro... (S01.131)	12195704,
KLK4_HUMAN	111	YSRS.\|.SRYL	inferred from experiment	unknown	MEROPS	Magdolen V	Beaufort N et al.:Interplay of human tissue kalli... (S01.251)	16497155,
CATG_HUMAN	114	SRYL.\|.LECI	inferred from experiment	unknown	MEROPS	Pidard D	Beaufort N et al.:Proteolytic regulation of the u... (S01.133)	14688365,
KLK4_HUMAN	303	QYRS.\|.SGAA	inferred from experiment	unknown	MEROPS	Magdolen V	Beaufort N et al.:Interplay of human tissue kalli... (S01.251)	16497155,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)