O60235: Transmembrane protease serine 11D

General Information

Protein names	- Transmembrane protease serine 11D - 3.4.21.- - Airway trypsin-like protease - Transmembrane protease serine 11D non-catalytic chain - Transmembrane protease serine 11D catalytic chain
Gene names	TMPRSS11D
Organism	Homo sapiens
Protease Family	S01.047
Protease ID	S01.047
Chromosome location
UniProt ID	O60235

3 N-termini

3 C-termini

0 Cleavages

6 Substrates

Sequence

        10         20         30         40         50         60
MYRPARVTST SRFLNPYVVC FIVVAGVVIL AVTIALLVYF LAFDQKSYFY RSSFQLLNVE
        70         80         90        100        110        120
YNSQLNSPAT QEYRTLSGRI ESLITKTFKE SNLRNQFIRA HVAKLRQDGS GVRADVVMKF
       130        140        150        160        170        180
QFTRNNNGAS MKSRIESVLR QMLNNSGNLE INPSTEITSL TDQAAANWLI NECGAGPDLI
       190        200        210        220        230        240
TLSEQRILGG TEAEEGSWPW QVSLRLNNAH HCGGSLINNM WILTAAHCFR SNSNPRDWIA
       250        260        270        280        290        300
TSGISTTFPK LRMRVRNILI HNNYKSATHE NDIALVRLEN SVTFTKDIHS VCLPAATQNI
       310        320        330        340        350        360
PPGSTAYVTG WGAQEYAGHT VPELRQGQVR IISNDVCNAP HSYNGAILSG MLCAGVPQGG
       370        380        390        400        410
VDACQGDSGG PLVQEDSRRL WFIVGIVSWG DQCGLPDKPG VYTRVTAYLD WIRQQTGI

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 0 Cleavages - 6 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O60235-1-unknown	MYRPAR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O60235-118-unknown	MKFQFT...	118	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442045
O60235-187-unknown	ILGGTE...	187	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LSEQRI	186	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VCNAPH	340	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000421381
...QQTGI	418	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
UPAR_HUMAN	105	SGRA.\|.AVTY	inferred from experiment	unknown	MEROPS	Pidard D	Beaufort N et al.:The human airway trypsin-like p... (S01.047)	17237151,
UPAR-Isoform3_HUMAN	105	SGRA.\|.AVTY	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31852
UPAR-Isoform2_HUMAN	105	SGRA.\|.AVTY	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31852
UPAR_HUMAN	111	YSRS.\|.SRYL	inferred from experiment	unknown	MEROPS	Pidard D	Beaufort N et al.:The human airway trypsin-like p... (S01.047)	17237151,
UPAR-Isoform3_HUMAN	111	YSRS.\|.SRYL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31855
UPAR-Isoform2_HUMAN	111	YSRS.\|.SRYL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31855