TopFIND 4.0

Q99542: Matrix metalloproteinase-19

General Information

Protein names
- Matrix metalloproteinase-19
- MMP-19
- 3.4.24.-
- Matrix metalloproteinase RASI
- Matrix metalloproteinase-18
- MMP-18
Gene names MMP19
Organism Homo sapiens
Protease Family M10.021
Protease ID M10.021
Chromosome location
UniProt ID Q99542

3

N-termini

1

C-termini

0

Cleavages

18

Substrates

Sequence

        10         20         30         40         50         60 
MNCQQLWLGF LLPMTVSGRV LGLAEVAPVD YLSQYGYLQK PLEGSNNFKP EDITEALRAF 
        70         80         90        100        110        120 
QEASELPVSG QLDDATRARM RQPRCGLEDP FNQKTLKYLL LGRWRKKHLT FRILNLPSTL 
       130        140        150        160        170        180 
PPHTARAALR QAFQDWSNVA PLTFQEVQAG AADIRLSFHG RQSSYCSNTF DGPGRVLAHA 
       190        200        210        220        230        240 
DIPELGSVHF DEDEFWTEGT YRGVNLRIIA AHEVGHALGL GHSRYSQALM APVYEGYRPH 
       250        260        270        280        290        300 
FKLHPDDVAG IQALYGKKSP VIRDEEEEET ELPTVPPVPT EPSPMPDPCS SELDAMMLGP 
       310        320        330        340        350        360 
RGKTYAFKGD YVWTVSDSGP GPLFRVSALW EGLPGNLDAA VYSPRTQWIH FFKGDKVWRY 
       370        380        390        400        410        420 
INFKMSPGFP KKLNRVEPNL DAALYWPLNQ KVFLFKGSGY WQWDELARTD FSSYPKPIKG 
       430        440        450        460        470        480 
LFTGVPNQPS AAMSWQDGRV YFFKGKVYWR LNQQLRVEKG YPRNISHNWM HCRPRTIDTT 
       490        500    
PSGGNTTPSG TGITLDTTLS ATETTFEY

Isoforms

- Isoform 2 of Matrix metalloproteinase-19 - Isoform 3 of Matrix metalloproteinase-19 - Isoform 4 of Matrix metalloproteinase-19

Sequence View

        10         20         30         40         50         60 
MNCQQLWLGF LLPMTVSGRV LGLAEVAPVD YLSQYGYLQK PLEGSNNFKP EDITEALRAF 
        70         80         90        100        110        120 
QEASELPVSG QLDDATRARM RQPRCGLEDP FNQKTLKYLL LGRWRKKHLT FRILNLPSTL 
       130        140        150        160        170        180 
PPHTARAALR QAFQDWSNVA PLTFQEVQAG AADIRLSFHG RQSSYCSNTF DGPGRVLAHA 
       190        200        210        220        230        240 
DIPELGSVHF DEDEFWTEGT YRGVNLRIIA AHEVGHALGL GHSRYSQALM APVYEGYRPH 
       250        260        270        280        290        300 
FKLHPDDVAG IQALYGKKSP VIRDEEEEET ELPTVPPVPT EPSPMPDPCS SELDAMMLGP 
       310        320        330        340        350        360 
RGKTYAFKGD YVWTVSDSGP GPLFRVSALW EGLPGNLDAA VYSPRTQWIH FFKGDKVWRY 
       370        380        390        400        410        420 
INFKMSPGFP KKLNRVEPNL DAALYWPLNQ KVFLFKGSGY WQWDELARTD FSSYPKPIKG 
       430        440        450        460        470        480 
LFTGVPNQPS AAMSWQDGRV YFFKGKVYWR LNQQLRVEKG YPRNISHNWM HCRPRTIDTT 
       490        500    
PSGGNTTPSG TGITLDTTLS ATETTFEY         10         20         30         40         50         60 
MNCQQLWLGF LLPMTVSGRV LGLAEVAPVD YLSQYGYLQK PLEGSNNFKP EDITEALRAF 
        70         80         90        100        110        120 
QEASELPVSG QLDDATRARM RQPRCGLEDP FNQKTLKYLL LGRWRKKHLT FRILNLPSTL 
       130        140        150        160        170        180 
PPHTARAALR QAFQDWSNVA PLTFQEVQAG AADIRLSFHG RQSSYCSNTF DGPGRVLAHA 
       190        200        210        220        230        240 
DIPELGSVHF DEDEFWTEGT YRGVNLRIIA AHEVGHALGL GHSRYSQALM APVYEGYRPH 
       250        260        270        280        290        300 
FKLHPDDVAG IQALYGKKSP VIRDEEEEET ELPTVPPVPT EPSPMPDPCS SELDAMMLGP 
       310        320        330        340        350        360 
RGKTYAFKGD YVWTVSDSGP GPLFRVSALW EGLPGNLDAA VYSPRTQWIH FFKGDKVWRY 
       370        380        390        400        410        420 
INFKMSPGFP KKLNRVEPNL DAALYWPLNQ KVFLFKGSGY WQWDELARTD FSSYPKPIKG 
       430        440        450        460        470        480 
LFTGVPNQPS AAMSWQDGRV YFFKGKVYWR LNQQLRVEKG YPRNISHNWM HCRPRTIDTT 
       490        500    
PSGGNTTPSG TGITLDTTLS ATETTFEY         10         20         30         40         50         60 
MNCQQLWLGF LLPMTVSGRV LGLAEVAPVD YLSQYGYLQK PLEGSNNFKP EDITEALRAF 
        70         80         90        100        110        120 
QEASELPVSG QLDDATRARM RQPRCGLEDP FNQKTLKYLL LGRWRKKHLT FRILNLPSTL 
       130        140        150        160        170        180 
PPHTARAALR QAFQDWSNVA PLTFQEVQAG AADIRLSFHG RQSSYCSNTF DGPGRVLAHA 
       190        200        210        220        230        240 
DIPELGSVHF DEDEFWTEGT YRGVNLRIIA AHEVGHALGL GHSRYSQALM APVYEGYRPH 
       250        260        270        280        290        300 
FKLHPDDVAG IQALYGKKSP VIRDEEEEET ELPTVPPVPT EPSPMPDPCS SELDAMMLGP 
       310        320        330        340        350        360 
RGKTYAFKGD YVWTVSDSGP GPLFRVSALW EGLPGNLDAA VYSPRTQWIH FFKGDKVWRY 
       370        380        390        400        410        420 
INFKMSPGFP KKLNRVEPNL DAALYWPLNQ KVFLFKGSGY WQWDELARTD FSSYPKPIKG 
       430        440        450        460        470        480 
LFTGVPNQPS AAMSWQDGRV YFFKGKVYWR LNQQLRVEKG YPRNISHNWM HCRPRTIDTT 
       490        500    
PSGGNTTPSG TGITLDTTLS ATETTFEY



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Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 18 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...TTFEY 508 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...TTFEY 508 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt76906

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates