TopFIND 4.0

P42830: C-X-C motif chemokine 5

General Information

Protein names	- C-X-C motif chemokine 5 - ENA-78(1-78) - Epithelial-derived neutrophil-activating protein 78 - Neutrophil-activating peptide ENA-78 - Small-inducible cytokine B5 - ENA-78(8-78) - ENA-78(9-78)
Gene names	CXCL5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P42830

11

N-termini

10

C-termini

10

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MSLLSSRAAR VPGPSSSLCA LLVLLLLLTQ PGPIASAGPA AAVLRELRCV CLQTTQGVHP
70 80 90 100 110
KMISNLQVFA IGPQCSKVEV VASLKNGKEI CLDPEAPFLK KVIQKILDGG NKEN

Isoforms

Sequence View

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

11 N-termini - 10 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P42830-8-unknown	AARVPG...	8		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC35029
P42830-37-unknown	AGPAAA...	37		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P42830-42-unknown	AVLREL...	42		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26441
P42830-43-unknown	VLRELR...	43		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26442
P42830-44-unknown	LRELRC...	44		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P42830-44-unknown	LRELRC...	44		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25094
P42830-44-unknown	LRELRC...	44		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26443
P42830-45-unknown	RELRCV...	45		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P42830-46-unknown	ELRCVC...	46		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21794
P42830-47-unknown	LRCVCL...	47		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26444
P42830-66-unknown	LQVFAI...	66		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26445
P42830-76-unknown	SKVEVV...	76		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26446
P42830-76-unknown	SKVEVV...	76		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P42830-76-unknown	SKVEVV...	76		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P42830-84-unknown	LKNGKE...	84		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26447

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...LLSSRA	7	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC35029
	...AGPAAA	41	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26441
	...GPAAAV	42	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26442
	...PAAAVL	43	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25094
	...PAAAVL	43	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26443
	...AAVLRE	45	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21794
	...AVLREL	46	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26444
	...KMISNL	65	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26445
	...IGPQCS	75	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26446
	...EVVASL	83	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26447
	...GNKEN	114	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP25_HUMAN	7	SSRA.\|.AARV		MS other		Overall Lab	recMMP-Chemokine_AStarr2012B	22367194,
MMP9_HUMAN	41	PAAA.\|.AVLR	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,
MMP9_HUMAN	42	AAAV.\|.VLRE	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,
MMP8_HUMAN	43	AAVL.\|.LREL	inferred from experiment	unknown	MEROPS	Overall CM	Tester AM et al.:LPS responsiveness and neutroph... (M10.013)	17375198,
MMP9_HUMAN	43	AAVL.\|.LREL	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,
MMP1_HUMAN	45	VLRE.\|.ELRC	inferred from experiment	unknown	MEROPS	Overall CM	Tester AM et al.:LPS responsiveness and neutroph... (M10.013)	17375198,
MMP9_HUMAN	46	LREL.\|.LRCV	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,
MMP9_HUMAN	65	ISNL.\|.LQVF	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,
MMP9_HUMAN	75	PQCS.\|.SKVE	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,
MMP9_HUMAN	83	VASL.\|.LKNG	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)