TopFIND 4.0

P13236: C-C motif chemokine 4

General Information

Protein names	- C-C motif chemokine 4 - G-26 T-lymphocyte-secreted protein - HC21 - Lymphocyte activation gene 1 protein - LAG-1 - MIP-1-beta(1-69) - Macrophage inflammatory protein 1-beta - MIP-1-beta - PAT 744 - Protein H400 - SIS-gamma - Small-inducible cytokine A4 - T-cell activation protein 2 - ACT-2 - MIP-1-beta(3-69)
Gene names	CCL4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P13236

8

N-termini

7

C-termini

16

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MKLCVTVLSL LMLVAAFCSP ALSAPMGSDP PTACCFSYTA RKLPRNFVVD YYETSSLCSQ
70 80 90
PAVVFQTKRS KQVCADPSES WVQEYVYDLE LN

Isoforms

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 7 C-termini - 16 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P13236-6-unknown	TVLSLL...	6		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34897
P13236-6-unknown	TVLSLL...	6		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34912
P13236-6-unknown	TVLSLL...	6		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34957
P13236-7-unknown	VLSLLM...	7		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34848
P13236-7-unknown	VLSLLM...	7		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34899
P13236-7-unknown	VLSLLM...	7		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34914
P13236-7-unknown	VLSLLM...	7		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34993
P13236-7-unknown	VLSLLM...	7		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC35033
P13236-14-unknown	VAAFCS...	14		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC35011
P13236-16-unknown	AFCSPA...	16		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34824
P13236-24-unknown	APMGSD...	24		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P13236-26-unknown	MGSDPP...	26		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P13236-45-unknown	RNFVVD...	45		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34898
P13236-45-unknown	RNFVVD...	45		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34913
P13236-45-unknown	RNFVVD...	45		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34935
P13236-62-unknown	AVVFQT...	62		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34825
P13236-62-unknown	AVVFQT...	62		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34956
P13236-62-unknown	AVVFQT...	62		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC35012

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...MKLCVT	5	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34897
	...MKLCVT	5	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34912
	...MKLCVT	5	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34957
	...KLCVTV	6	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34848
	...KLCVTV	6	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34899
	...KLCVTV	6	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34914
	...KLCVTV	6	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34993
	...KLCVTV	6	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC35033
	...SLLMLV	13	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC35011
	...LMLVAA	15	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34824
	...ARKLPR	44	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34898
	...ARKLPR	44	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34913
	...ARKLPR	44	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34935
	...LCSQPA	61	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34825
	...LCSQPA	61	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34956
	...LCSQPA	61	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC35012
	...DLELN	92	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP14_HUMAN	5	LCVT.\|.TVLS		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP2_HUMAN	5	LCVT.\|.TVLS		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP7_HUMAN	5	LCVT.\|.TVLS		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP12_HUMAN	6	CVTV.\|.VLSL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP14_HUMAN	6	CVTV.\|.VLSL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP2_HUMAN	6	CVTV.\|.VLSL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP8_HUMAN	6	CVTV.\|.VLSL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP25_HUMAN	6	CVTV.\|.VLSL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012B	22367194,
MMP9_HUMAN	13	LMLV.\|.VAAF		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP1_HUMAN	15	LVAA.\|.AFCS		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP14_HUMAN	44	KLPR.\|.RNFV		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP2_HUMAN	44	KLPR.\|.RNFV		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP3_HUMAN	44	KLPR.\|.RNFV		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP1_HUMAN	61	SQPA.\|.AVVF		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP7_HUMAN	61	SQPA.\|.AVVF		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP9_HUMAN	61	SQPA.\|.AVVF		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)