P08519: Apolipoprotein(a)

General Information

Protein names	- Apolipoprotein(a) - Apo(a) - Lp(a) - 3.4.21.-
Gene names	LPA
Organism	Homo sapiens
Protease Family
Protease ID	S01.999
Chromosome location
UniProt ID	P08519

9 N-termini

5 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEHKEVVLLL LLFLKSAAPE QSHVVQDCYH GDGQSYRGTY STTVTGRTCQ AWSSMTPHQH
        70         80         90        100        110        120
NRTTENYPNA GLIMNYCRNP DAVAAPYCYT RDPGVRWEYC NLTQCSDAEG TAVAPPTVTP
       130        140        150        160        170        180
VPSLEAPSEQ APTEQRPGVQ ECYHGNGQSY RGTYSTTVTG RTCQAWSSMT PHSHSRTPEY
       190        200        210        220        230        240
YPNAGLIMNY CRNPDAVAAP YCYTRDPGVR WEYCNLTQCS DAEGTAVAPP TVTPVPSLEA
       250        260        270        280        290        300
PSEQAPTEQR PGVQECYHGN GQSYRGTYST TVTGRTCQAW SSMTPHSHSR TPEYYPNAGL
       310        320        330        340        350        360
IMNYCRNPDA VAAPYCYTRD PGVRWEYCNL TQCSDAEGTA VAPPTVTPVP SLEAPSEQAP
       370        380        390        400        410        420
TEQRPGVQEC YHGNGQSYRG TYSTTVTGRT CQAWSSMTPH SHSRTPEYYP NAGLIMNYCR
       430        440        450        460        470        480
NPDAVAAPYC YTRDPGVRWE YCNLTQCSDA EGTAVAPPTV TPVPSLEAPS EQAPTEQRPG
       490        500        510        520        530        540
VQECYHGNGQ SYRGTYSTTV TGRTCQAWSS MTPHSHSRTP EYYPNAGLIM NYCRNPDAVA
       550        560        570        580        590        600
APYCYTRDPG VRWEYCNLTQ CSDAEGTAVA PPTVTPVPSL EAPSEQAPTE QRPGVQECYH
       610        620        630        640        650        660
GNGQSYRGTY STTVTGRTCQ AWSSMTPHSH SRTPEYYPNA GLIMNYCRNP DAVAAPYCYT
       670        680        690        700        710        720
RDPGVRWEYC NLTQCSDAEG TAVAPPTVTP VPSLEAPSEQ APTEQRPGVQ ECYHGNGQSY
       730        740        750        760        770        780
RGTYSTTVTG RTCQAWSSMT PHSHSRTPEY YPNAGLIMNY CRNPDAVAAP YCYTRDPGVR
       790        800        810        820        830        840
WEYCNLTQCS DAEGTAVAPP TVTPVPSLEA PSEQAPTEQR PGVQECYHGN GQSYRGTYST
       850        860        870        880        890        900
TVTGRTCQAW SSMTPHSHSR TPEYYPNAGL IMNYCRNPDA VAAPYCYTRD PGVRWEYCNL
       910        920        930        940        950        960
TQCSDAEGTA VAPPTVTPVP SLEAPSEQAP TEQRPGVQEC YHGNGQSYRG TYSTTVTGRT
       970        980        990       1000       1010       1020
CQAWSSMTPH SHSRTPEYYP NAGLIMNYCR NPDAVAAPYC YTRDPGVRWE YCNLTQCSDA
      1030       1040       1050       1060       1070       1080
EGTAVAPPTV TPVPSLEAPS EQAPTEQRPG VQECYHGNGQ SYRGTYSTTV TGRTCQAWSS
      1090       1100       1110       1120       1130       1140
MTPHSHSRTP EYYPNAGLIM NYCRNPDAVA APYCYTRDPG VRWEYCNLTQ CSDAEGTAVA
      1150       1160       1170       1180       1190       1200
PPTVTPVPSL EAPSEQAPTE QRPGVQECYH GNGQSYRGTY STTVTGRTCQ AWSSMTPHSH
      1210       1220       1230       1240       1250       1260
SRTPEYYPNA GLIMNYCRNP DAVAAPYCYT RDPGVRWEYC NLTQCSDAEG TAVAPPTVTP
      1270       1280       1290       1300       1310       1320
VPSLEAPSEQ APTEQRPGVQ ECYHGNGQSY RGTYSTTVTG RTCQAWSSMT PHSHSRTPEY
      1330       1340       1350       1360       1370       1380
YPNAGLIMNY CRNPDAVAAP YCYTRDPGVR WEYCNLTQCS DAEGTAVAPP TVTPVPSLEA
      1390       1400       1410       1420       1430       1440
PSEQAPTEQR PGVQECYHGN GQSYRGTYST TVTGRTCQAW SSMTPHSHSR TPEYYPNAGL
      1450       1460       1470       1480       1490       1500
IMNYCRNPDA VAAPYCYTRD PGVRWEYCNL TQCSDAEGTA VAPPTVTPVP SLEAPSEQAP
      1510       1520       1530       1540       1550       1560
TEQRPGVQEC YHGNGQSYRG TYSTTVTGRT CQAWSSMTPH SHSRTPEYYP NAGLIMNYCR
      1570       1580       1590       1600       1610       1620
NPDAVAAPYC YTRDPGVRWE YCNLTQCSDA EGTAVAPPTV TPVPSLEAPS EQAPTEQRPG
      1630       1640       1650       1660       1670       1680
VQECYHGNGQ SYRGTYSTTV TGRTCQAWSS MTPHSHSRTP EYYPNAGLIM NYCRNPDAVA
      1690       1700       1710       1720       1730       1740
APYCYTRDPG VRWEYCNLTQ CSDAEGTAVA PPTVTPVPSL EAPSEQAPTE QRPGVQECYH
      1750       1760       1770       1780       1790       1800
GNGQSYRGTY STTVTGRTCQ AWSSMTPHSH SRTPEYYPNA GLIMNYCRNP DAVAAPYCYT
      1810       1820       1830       1840       1850       1860
RDPGVRWEYC NLTQCSDAEG TAVAPPTVTP VPSLEAPSEQ APTEQRPGVQ ECYHGNGQSY
      1870       1880       1890       1900       1910       1920
RGTYSTTVTG RTCQAWSSMT PHSHSRTPEY YPNAGLIMNY CRNPDAVAAP YCYTRDPGVR
      1930       1940       1950       1960       1970       1980
WEYCNLTQCS DAEGTAVAPP TVTPVPSLEA PSEQAPTEQR PGVQECYHGN GQSYRGTYST
      1990       2000       2010       2020       2030       2040
TVTGRTCQAW SSMTPHSHSR TPEYYPNAGL IMNYCRNPDA VAAPYCYTRD PGVRWEYCNL
      2050       2060       2070       2080       2090       2100
TQCSDAEGTA VAPPTVTPVP SLEAPSEQAP TEQRPGVQEC YHGNGQSYRG TYSTTVTGRT
      2110       2120       2130       2140       2150       2160
CQAWSSMTPH SHSRTPEYYP NAGLIMNYCR NPDAVAAPYC YTRDPGVRWE YCNLTQCSDA
      2170       2180       2190       2200       2210       2220
EGTAVAPPTV TPVPSLEAPS EQAPTEQRPG VQECYHGNGQ SYRGTYSTTV TGRTCQAWSS
      2230       2240       2250       2260       2270       2280
MTPHSHSRTP EYYPNAGLIM NYCRNPDAVA APYCYTRDPG VRWEYCNLTQ CSDAEGTAVA
      2290       2300       2310       2320       2330       2340
PPTVTPVPSL EAPSEQAPTE QRPGVQECYH GNGQSYRGTY STTVTGRTCQ AWSSMTPHSH
      2350       2360       2370       2380       2390       2400
SRTPEYYPNA GLIMNYCRNP DAVAAPYCYT RDPGVRWEYC NLTQCSDAEG TAVAPPTVTP
      2410       2420       2430       2440       2450       2460
VPSLEAPSEQ APTEQRPGVQ ECYHGNGQSY RGTYSTTVTG RTCQAWSSMT PHSHSRTPEY
      2470       2480       2490       2500       2510       2520
YPNAGLIMNY CRNPDAVAAP YCYTRDPGVR WEYCNLTQCS DAEGTAVAPP TVTPVPSLEA
      2530       2540       2550       2560       2570       2580
PSEQAPTEQR PGVQECYHGN GQSYRGTYST TVTGRTCQAW SSMTPHSHSR TPEYYPNAGL
      2590       2600       2610       2620       2630       2640
IMNYCRNPDA VAAPYCYTRD PGVRWEYCNL TQCSDAEGTA VAPPTVTPVP SLEAPSEQAP
      2650       2660       2670       2680       2690       2700
TEQRPGVQEC YHGNGQSYRG TYSTTVTGRT CQAWSSMTPH SHSRTPEYYP NAGLIMNYCR
      2710       2720       2730       2740       2750       2760
NPDAVAAPYC YTRDPGVRWE YCNLTQCSDA EGTAVAPPTV TPVPSLEAPS EQAPTEQRPG
      2770       2780       2790       2800       2810       2820
VQECYHGNGQ SYRGTYSTTV TGRTCQAWSS MTPHSHSRTP EYYPNAGLIM NYCRNPDAVA
      2830       2840       2850       2860       2870       2880
APYCYTRDPG VRWEYCNLTQ CSDAEGTAVA PPTVTPVPSL EAPSEQAPTE QRPGVQECYH
      2890       2900       2910       2920       2930       2940
GNGQSYRGTY STTVTGRTCQ AWSSMTPHSH SRTPEYYPNA GLIMNYCRNP DAVAAPYCYT
      2950       2960       2970       2980       2990       3000
RDPGVRWEYC NLTQCSDAEG TAVAPPTVTP VPSLEAPSEQ APTEQRPGVQ ECYHGNGQSY
      3010       3020       3030       3040       3050       3060
RGTYSTTVTG RTCQAWSSMT PHSHSRTPEY YPNAGLIMNY CRNPDAVAAP YCYTRDPGVR
      3070       3080       3090       3100       3110       3120
WEYCNLTQCS DAEGTAVAPP TVTPVPSLEA PSEQAPTEQR PGVQECYHGN GQSYRGTYST
      3130       3140       3150       3160       3170       3180
TVTGRTCQAW SSMTPHSHSR TPEYYPNAGL IMNYCRNPDA VAAPYCYTRD PGVRWEYCNL
      3190       3200       3210       3220       3230       3240
TQCSDAEGTA VAPPTVTPVP SLEAPSEQAP TEQRPGVQEC YHGNGQSYRG TYSTTVTGRT
      3250       3260       3270       3280       3290       3300
CQAWSSMTPH SHSRTPEYYP NAGLIMNYCR NPDAVAAPYC YTRDPGVRWE YCNLTQCSDA
      3310       3320       3330       3340       3350       3360
EGTAVAPPTV TPVPSLEAPS EQAPTEQRPG VQECYHGNGQ SYRGTYSTTV TGRTCQAWSS
      3370       3380       3390       3400       3410       3420
MTPHSHSRTP EYYPNAGLIM NYCRNPDPVA APYCYTRDPS VRWEYCNLTQ CSDAEGTAVA
      3430       3440       3450       3460       3470       3480
PPTITPIPSL EAPSEQAPTE QRPGVQECYH GNGQSYQGTY FITVTGRTCQ AWSSMTPHSH
      3490       3500       3510       3520       3530       3540
SRTPAYYPNA GLIKNYCRNP DPVAAPWCYT TDPSVRWEYC NLTRCSDAEW TAFVPPNVIL
      3550       3560       3570       3580       3590       3600
APSLEAFFEQ ALTEETPGVQ DCYYHYGQSY RGTYSTTVTG RTCQAWSSMT PHQHSRTPEN
      3610       3620       3630       3640       3650       3660
YPNAGLTRNY CRNPDAEIRP WCYTMDPSVR WEYCNLTQCL VTESSVLATL TVVPDPSTEA
      3670       3680       3690       3700       3710       3720
SSEEAPTEQS PGVQDCYHGD GQSYRGSFST TVTGRTCQSW SSMTPHWHQR TTEYYPNGGL
      3730       3740       3750       3760       3770       3780
TRNYCRNPDA EISPWCYTMD PNVRWEYCNL TQCPVTESSV LATSTAVSEQ APTEQSPTVQ
      3790       3800       3810       3820       3830       3840
DCYHGDGQSY RGSFSTTVTG RTCQSWSSMT PHWHQRTTEY YPNGGLTRNY CRNPDAEIRP
      3850       3860       3870       3880       3890       3900
WCYTMDPSVR WEYCNLTQCP VMESTLLTTP TVVPVPSTEL PSEEAPTENS TGVQDCYRGD
      3910       3920       3930       3940       3950       3960
GQSYRGTLST TITGRTCQSW SSMTPHWHRR IPLYYPNAGL TRNYCRNPDA EIRPWCYTMD
      3970       3980       3990       4000       4010       4020
PSVRWEYCNL TRCPVTESSV LTTPTVAPVP STEAPSEQAP PEKSPVVQDC YHGDGRSYRG
      4030       4040       4050       4060       4070       4080
ISSTTVTGRT CQSWSSMIPH WHQRTPENYP NAGLTENYCR NPDSGKQPWC YTTDPCVRWE
      4090       4100       4110       4120       4130       4140
YCNLTQCSET ESGVLETPTV VPVPSMEAHS EAAPTEQTPV VRQCYHGNGQ SYRGTFSTTV
      4150       4160       4170       4180       4190       4200
TGRTCQSWSS MTPHRHQRTP ENYPNDGLTM NYCRNPDADT GPWCFTMDPS IRWEYCNLTR
      4210       4220       4230       4240       4250       4260
CSDTEGTVVA PPTVIQVPSL GPPSEQDCMF GNGKGYRGKK ATTVTGTPCQ EWAAQEPHRH
      4270       4280       4290       4300       4310       4320
STFIPGTNKW AGLEKNYCRN PDGDINGPWC YTMNPRKLFD YCDIPLCASS SFDCGKPQVE
      4330       4340       4350       4360       4370       4380
PKKCPGSIVG GCVAHPHSWP WQVSLRTRFG KHFCGGTLIS PEWVLTAAHC LKKSSRPSSY
      4390       4400       4410       4420       4430       4440
KVILGAHQEV NLESHVQEIE VSRLFLEPTQ ADIALLKLSR PAVITDKVMP ACLPSPDYMV
      4450       4460       4470       4480       4490       4500
TARTECYITG WGETQGTFGT GLLKEAQLLV IENEVCNHYK YICAEHLARG TDSCQGDSGG
      4510       4520       4530       4540
PLVCFEKDKY ILQGVTSWGL GCARPNKPGV YARVSRFVTW IEGMMRNN

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 5 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P08519-20-unknown	EQSHVV...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P08519-23-unknown	HVVQDC...	23		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P08519-38-unknown	GTYSTT...	38		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P08519-3538-unknown	VILAPS...	3538	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20138
P08519-3540-unknown	LAPSLE...	3540	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9316
P08519-3540-unknown	LAPSLE...	3540	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8344
P08519-3866-unknown	LLTTPT...	3866	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9317
P08519-4134-unknown	GTFSTT...	4134		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P08519-4216-unknown	QVPSLG...	4216	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9318
P08519-4270-unknown	WAGLEK...	4270		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FVPPNV	3537	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20138
...PPNVIL	3539	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9316
...PPNVIL	3539	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8344
...VMESTL	3865	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9317
...PPTVIQ	4215	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9318
...MMRNN	4548	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP12_HUMAN	3537	PPNV.\|.VILA	inferred from experiment	unknown	MEROPS	Scanu AM	Edelstein C et al.:Macrophage metalloelastase, MMP... (M10.009)	10187779,
ELNE_HUMAN	3539	NVIL.\|.LAPS	inferred from experiment	unknown	MEROPS	Scanu AM	Edelstein C et al.:Polymorphonuclear cells isolate... (S01.131)	9111002,
CELA1_HUMAN	3539	NVIL.\|.LAPS	inferred from experiment	unknown	MEROPS	Scanu AM	Edelstein C et al.:Functional and metabolic differ... (S01.153)	8864963,
ELNE_HUMAN	3865	ESTL.\|.LLTT	inferred from experiment	unknown	MEROPS	Scanu AM	Edelstein C et al.:Polymorphonuclear cells isolate... (S01.131)	9111002,
ELNE_HUMAN	4215	TVIQ.\|.QVPS	inferred from experiment	unknown	MEROPS	Scanu AM	Edelstein C et al.:Polymorphonuclear cells isolate... (S01.131)	9111002,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)