P10646: Tissue factor pathway inhibitor

General Information

Protein names	- Tissue factor pathway inhibitor - TFPI - Extrinsic pathway inhibitor - EPI - Lipoprotein-associated coagulation inhibitor - LACI
Gene names	TFPI
Organism	Homo sapiens
Protease Family
Protease ID	I02.950
Chromosome location
UniProt ID	P10646

6 N-termini

5 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MIYTMKKVHA LWASVCLLLN LAPAPLNADS EEDEEHTIIT DTELPPLKLM HSFCAFKADD
        70         80         90        100        110        120
GPCKAIMKRF FFNIFTRQCE EFIYGGCEGN QNRFESLEEC KKMCTRDNAN RIIKTTLQQE
       130        140        150        160        170        180
KPDFCFLEED PGICRGYITR YFYNNQTKQC ERFKYGGCLG NMNNFETLEE CKNICEDGPN
       190        200        210        220        230        240
GFQVDNYGTQ LNAVNNSLTP QSTKVPSLFE FHGPSWCLTP ADRGLCRANE NRFYYNSVIG
       250        260        270        280        290        300
KCRPFKYSGC GGNENNFTSK QECLRACKKG FIQRISKGGL IKTKRKRKKQ RVKIAYEEIF

VKNM

Isoforms

- Isoform Beta of Tissue factor pathway inhibitor

Sequence View

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Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P10646-1-unknown	MIYTMK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92008
P10646-29-unknown	DSEEDE...	29	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P10646-29-unknown	DSEEDE...	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114501
P10646-49-unknown	LMHSFC...	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25672
P10646-49-unknown	LMHSFC...	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20139
P10646-49-unknown	LMHSFC...	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24028
P10646-49-unknown	LMHSFC...	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21740
P10646-49-unknown	LMHSFC...	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25071
P10646-49-unknown	LMHSFC...	49	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139076
P10646-112-unknown	IIKTTL...	112	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20141
P10646-112-unknown	IIKTTL...	112	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143080
P10646-116-unknown	TLQQEK...	116	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9342
P10646-116-unknown	TLQQEK...	116	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143281
P10646-203-unknown	TKVPSL...	203	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20143
P10646-203-unknown	TKVPSL...	203	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25073

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LPPLKL	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25672
...LPPLKL	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20139
...LPPLKL	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24028
...LPPLKL	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21740
...LPPLKL	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25071
...LPPLKL	48	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122147
...DNANRI	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20141
...DNANRI	111	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126299
...RIIKTT	115	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9342
...RIIKTT	115	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126511
...LTPQST	202	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20143
...LTPQST	202	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25073
...LTPQST	202	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155661
...FVKNM	304	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP9_HUMAN	48	PLKL.\|.LMHS	inferred from experiment	unknown	MEROPS	Shapiro SD	Belaaouaj AA et al.:Matrix metalloproteinases cleav... (M10.009)	10859319,
MMP12_HUMAN	48	PLKL.\|.LMHS	inferred from experiment	unknown	MEROPS	Shapiro SD	Belaaouaj AA et al.:Matrix metalloproteinases cleav... (M10.009)	10859319,
MMP7_HUMAN	48	PLKL.\|.LMHS	inferred from experiment	unknown	MEROPS	Shapiro SD	Belaaouaj AA et al.:Matrix metalloproteinases cleav... (M10.009)	10859319,
MMP1_HUMAN	48	PLKL.\|.LMHS	inferred from experiment	unknown	MEROPS	Shapiro SD	Belaaouaj AA et al.:Matrix metalloproteinases cleav... (M10.009)	10859319,
MMP8_HUMAN	48	PLKL.\|.LMHS	inferred from experiment	unknown	MEROPS	Mast AE	Cunningham AC et al.:Structural and functional chara... (M10.002)	12117418,
MMP12_HUMAN	111	ANRI.\|.IIKT	inferred from experiment	unknown	MEROPS	Shapiro SD	Belaaouaj AA et al.:Matrix metalloproteinases cleav... (M10.009)	10859319,
ELNE_HUMAN	115	IKTT.\|.TLQQ	inferred from experiment	unknown	MEROPS	Broze GJ Jr	Higuchi DA et al.:The effect of leukocyte elastas... (S01.131)	1558967,
MMP12_HUMAN	202	PQST.\|.TKVP	inferred from experiment	unknown	MEROPS	Shapiro SD	Belaaouaj AA et al.:Matrix metalloproteinases cleav... (M10.009)	10859319,
MMP8_HUMAN	202	PQST.\|.TKVP	inferred from experiment	unknown	MEROPS	Mast AE	Cunningham AC et al.:Structural and functional chara... (M10.002)	12117418,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)