P35556: Fibrillin-2

General Information

Protein names	- Fibrillin-2 - Fibrillin-2 C-terminal peptide {ECO:0000305}
Gene names	FBN2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P35556

4 N-termini

3 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGRRRRLCLQ LYFLWLGCVV LWAQGTAGQP QPPPPKPPRP QPPPQQVRSA TAGSEGGFLA
        70         80         90        100        110        120
PEYREEGAAV ASRVRRRGQQ DVLRGPNVCG SRFHSYCCPG WKTLPGGNQC IVPICRNSCG
       130        140        150        160        170        180
DGFCSRPNMC TCSSGQISST CGSKSIQQCS VRCMNGGTCA DDHCQCQKGY IGTYCGQPVC
       190        200        210        220        230        240
ENGCQNGGRC IGPNRCACVY GFTGPQCERD YRTGPCFTQV NNQMCQGQLT GIVCTKTLCC
       250        260        270        280        290        300
ATIGRAWGHP CEMCPAQPQP CRRGFIPNIR TGACQDVDEC QAIPGICQGG NCINTVGSFE
       310        320        330        340        350        360
CRCPAGHKQS ETTQKCEDID ECSIIPGICE TGECSNTVGS YFCVCPRGYV TSTDGSRCID
       370        380        390        400        410        420
QRTGMCFSGL VNGRCAQELP GRMTKMQCCC EPGRCWGIGT IPEACPVRGS EEYRRLCMDG
       430        440        450        460        470        480
LPMGGIPGSA GSRPGGTGGN GFAPSGNGNG YGPGGTGFIP IPGGNGFSPG VGGAGVGAGG
       490        500        510        520        530        540
QGPIITGLTI LNQTIDICKH HANLCLNGRC IPTVSSYRCE CNMGYKQDAN GDCIDVDECT
       550        560        570        580        590        600
SNPCTNGDCV NTPGSYYCKC HAGFQRTPTK QACIDIDECI QNGVLCKNGR CVNTDGSFQC
       610        620        630        640        650        660
ICNAGFELTT DGKNCVDHDE CTTTNMCLNG MCINEDGSFK CICKPGFVLA PNGRYCTDVD
       670        680        690        700        710        720
ECQTPGICMN GHCINSEGSF RCDCPPGLAV GMDGRVCVDT HMRSTCYGGI KKGVCVRPFP
       730        740        750        760        770        780
GAVTKSECCC ANPDYGFGEP CQPCPAKNSA EFHGLCSSGV GITVDGRDIN ECALDPDICA
       790        800        810        820        830        840
NGICENLRGS YRCNCNSGYE PDASGRNCID IDECLVNRLL CDNGLCRNTP GSYSCTCPPG
       850        860        870        880        890        900
YVFRTETETC EDINECESNP CVNGACRNNL GSFNCECSPG SKLSSTGLIC IDSLKGTCWL
       910        920        930        940        950        960
NIQDSRCEVN INGATLKSEC CATLGAAWGS PCERCELDTA CPRGLARIKG VTCEDVNECE
       970        980        990       1000       1010       1020
VFPGVCPNGR CVNSKGSFHC ECPEGLTLDG TGRVCLDIRM EQCYLKWDED ECIHPVPGKF
      1030       1040       1050       1060       1070       1080
RMDACCCAVG AAWGTECEEC PKPGTKEYET LCPRGAGFAN RGDVLTGRPF YKDINECKAF
      1090       1100       1110       1120       1130       1140
PGMCTYGKCR NTIGSFKCRC NSGFALDMEE RNCTDIDECR ISPDLCGSGI CVNTPGSFEC
      1150       1160       1170       1180       1190       1200
ECFEGYESGF MMMKNCMDID ECERNPLLCR GGTCVNTEGS FQCDCPLGHE LSPSREDCVD
      1210       1220       1230       1240       1250       1260
INECSLSDNL CRNGKCVNMI GTYQCSCNPG YQATPDRQGC TDIDECMIMN GGCDTQCTNS
      1270       1280       1290       1300       1310       1320
EGSYECSCSE GYALMPDGRS CADIDECENN PDICDGGQCT NIPGEYRCLC YDGFMASMDM
      1330       1340       1350       1360       1370       1380
KTCIDVNECD LNSNICMFGE CENTKGSFIC HCQLGYSVKK GTTGCTDVDE CEIGAHNCDM
      1390       1400       1410       1420       1430       1440
HASCLNIPGS FKCSCREGWI GNGIKCIDLD ECSNGTHQCS INAQCVNTPG SYRCACSEGF
      1450       1460       1470       1480       1490       1500
TGDGFTCSDV DECAENINLC ENGQCLNVPG AYRCECEMGF TPASDSRSCQ DIDECSFQNI
      1510       1520       1530       1540       1550       1560
CVFGTCNNLP GMFHCICDDG YELDRTGGNC TDIDECADPI NCVNGLCVNT PGRYECNCPP
      1570       1580       1590       1600       1610       1620
DFQLNPTGVG CVDNRVGNCY LKFGPRGDGS LSCNTEIGVG VSRSSCCCSL GKAWGNPCET
      1630       1640       1650       1660       1670       1680
CPPVNSTEYY TLCPGGEGFR PNPITIILED IDECQELPGL CQGGNCINTF GSFQCECPQG
      1690       1700       1710       1720       1730       1740
YYLSEDTRIC EDIDECFAHP GVCGPGTCYN TLGNYTCICP PEYMQVNGGH NCMDMRKSFC
      1750       1760       1770       1780       1790       1800
YRSYNGTTCE NELPFNVTKR MCCCTYNVGK AWNKPCEPCP TPGTADFKTI CGNIPGFTFD
      1810       1820       1830       1840       1850       1860
IHTGKAVDID ECKEIPGICA NGVCINQIGS FRCECPTGFS YNDLLLVCED IDECSNGDNL
      1870       1880       1890       1900       1910       1920
CQRNADCINS PGSYRCECAA GFKLSPNGAC VDRNECLEIP NVCSHGLCVD LQGSYQCICH
      1930       1940       1950       1960       1970       1980
NGFKASQDQT MCMDVDECER HPCGNGTCKN TVGSYNCLCY PGFELTHNND CLDIDECSSF
      1990       2000       2010       2020       2030       2040
FGQVCRNGRC FNEIGSFKCL CNEGYELTPD GKNCIDTNEC VALPGSCSPG TCQNLEGSFR
      2050       2060       2070       2080       2090       2100
CICPPGYEVK SENCIDINEC DEDPNICLFG SCTNTPGGFQ CLCPPGFVLS DNGRRCFDTR
      2110       2120       2130       2140       2150       2160
QSFCFTNFEN GKCSVPKAFN TTKAKCCCSK MPGEGWGDPC ELCPKDDEVA FQDLCPYGHG
      2170       2180       2190       2200       2210       2220
TVPSLHDTRE DVNECLESPG ICSNGQCINT DGSFRCECPM GYNLDYTGVR CVDTDECSIG
      2230       2240       2250       2260       2270       2280
NPCGNGTCTN VIGSFECNCN EGFEPGPMMN CEDINECAQN PLLCAFRCMN TFGSYECTCP
      2290       2300       2310       2320       2330       2340
IGYALREDQK MCKDLDECAE GLHDCESRGM MCKNLIGTFM CICPPGMARR PDGEGCVDEN
      2350       2360       2370       2380       2390       2400
ECRTKPGICE NGRCVNIIGS YRCECNEGFQ SSSSGTECLD NRQGLCFAEV LQTICQMASS
      2410       2420       2430       2440       2450       2460
SRNLVTKSEC CCDGGRGWGH QCELCPLPGT AQYKKICPHG PGYTTDGRDI DECKVMPNLC
      2470       2480       2490       2500       2510       2520
TNGQCINTMG SFRCFCKVGY TTDISGTSCI DLDECSQSPK PCNYICKNTE GSYQCSCPRG
      2530       2540       2550       2560       2570       2580
YVLQEDGKTC KDLDECQTKQ HNCQFLCVNT LGGFTCKCPP GFTQHHTACI DNNECGSQPS
      2590       2600       2610       2620       2630       2640
LCGAKGICQN TPGSFSCECQ RGFSLDATGL NCEDVDECDG NHRCQHGCQN ILGGYRCGCP
      2650       2660       2670       2680       2690       2700
QGYIQHYQWN QCVDENECSN PNACGSASCY NTLGSYKCAC PSGFSFDQFS SACHDVNECS
      2710       2720       2730       2740       2750       2760
SSKNPCNYGC SNTEGGYLCG CPPGYYRVGQ GHCVSGMGFN KGQYLSLDTE VDEENALSPE
      2770       2780       2790       2800       2810       2820
ACYECKINGY SKKDSRQKRS IHEPDPTAVE QISLESVDMD SPVNMKFNLS HLGSKEHILE
      2830       2840       2850       2860       2870       2880
LRPAIQPLNN HIRYVISQGN DDSVFRIHQR NGLSYLHTAK KKLMPGTYTL EITSIPLYKK
      2890       2900       2910
KELKKLEESN EDDYLLGELG EALRMRLQIQ LY

Isoforms

- Isoform 2 of Fibrillin-2

Sequence View

        10         20         30         40         50         60
MGRRRRLCLQ LYFLWLGCVV LWAQGTAGQP QPPPPKPPRP QPPPQQVRSA TAGSEGGFLA
        70         80         90        100        110        120
PEYREEGAAV ASRVRRRGQQ DVLRGPNVCG SRFHSYCCPG WKTLPGGNQC IVPICRNSCG
       130        140        150        160        170        180
DGFCSRPNMC TCSSGQISST CGSKSIQQCS VRCMNGGTCA DDHCQCQKGY IGTYCGQPVC
       190        200        210        220        230        240
ENGCQNGGRC IGPNRCACVY GFTGPQCERD YRTGPCFTQV NNQMCQGQLT GIVCTKTLCC
       250        260        270        280        290        300
ATIGRAWGHP CEMCPAQPQP CRRGFIPNIR TGACQDVDEC QAIPGICQGG NCINTVGSFE
       310        320        330        340        350        360
CRCPAGHKQS ETTQKCEDID ECSIIPGICE TGECSNTVGS YFCVCPRGYV TSTDGSRCID
       370        380        390        400        410        420
QRTGMCFSGL VNGRCAQELP GRMTKMQCCC EPGRCWGIGT IPEACPVRGS EEYRRLCMDG
       430        440        450        460        470        480
LPMGGIPGSA GSRPGGTGGN GFAPSGNGNG YGPGGTGFIP IPGGNGFSPG VGGAGVGAGG
       490        500        510        520        530        540
QGPIITGLTI LNQTIDICKH HANLCLNGRC IPTVSSYRCE CNMGYKQDAN GDCIDVDECT
       550        560        570        580        590        600
SNPCTNGDCV NTPGSYYCKC HAGFQRTPTK QACIDIDECI QNGVLCKNGR CVNTDGSFQC
       610        620        630        640        650        660
ICNAGFELTT DGKNCVDHDE CTTTNMCLNG MCINEDGSFK CICKPGFVLA PNGRYCTDVD
       670        680        690        700        710        720
ECQTPGICMN GHCINSEGSF RCDCPPGLAV GMDGRVCVDT HMRSTCYGGI KKGVCVRPFP
       730        740        750        760        770        780
GAVTKSECCC ANPDYGFGEP CQPCPAKNSA EFHGLCSSGV GITVDGRDIN ECALDPDICA
       790        800        810        820        830        840
NGICENLRGS YRCNCNSGYE PDASGRNCID IDECLVNRLL CDNGLCRNTP GSYSCTCPPG
       850        860        870        880        890        900
YVFRTETETC EDINECESNP CVNGACRNNL GSFNCECSPG SKLSSTGLIC IDSLKGTCWL
       910        920        930        940        950        960
NIQDSRCEVN INGATLKSEC CATLGAAWGS PCERCELDTA CPRGLARIKG VTCEDVNECE
       970        980        990       1000       1010       1020
VFPGVCPNGR CVNSKGSFHC ECPEGLTLDG TGRVCLDIRM EQCYLKWDED ECIHPVPGKF
      1030       1040       1050       1060       1070       1080
RMDACCCAVG AAWGTECEEC PKPGTKEYET LCPRGAGFAN RGDVLTGRPF YKDINECKAF
      1090       1100       1110       1120       1130       1140
PGMCTYGKCR NTIGSFKCRC NSGFALDMEE RNCTDIDECR ISPDLCGSGI CVNTPGSFEC
      1150       1160       1170       1180       1190       1200
ECFEGYESGF MMMKNCMDID ECERNPLLCR GGTCVNTEGS FQCDCPLGHE LSPSREDCVD
      1210       1220       1230       1240       1250       1260
INECSLSDNL CRNGKCVNMI GTYQCSCNPG YQATPDRQGC TDIDECMIMN GGCDTQCTNS
      1270       1280       1290       1300       1310       1320
EGSYECSCSE GYALMPDGRS CADIDECENN PDICDGGQCT NIPGEYRCLC YDGFMASMDM
      1330       1340       1350       1360       1370       1380
KTCIDVNECD LNSNICMFGE CENTKGSFIC HCQLGYSVKK GTTGCTDVDE CEIGAHNCDM
      1390       1400       1410       1420       1430       1440
HASCLNIPGS FKCSCREGWI GNGIKCIDLD ECSNGTHQCS INAQCVNTPG SYRCACSEGF
      1450       1460       1470       1480       1490       1500
TGDGFTCSDV DECAENINLC ENGQCLNVPG AYRCECEMGF TPASDSRSCQ DIDECSFQNI
      1510       1520       1530       1540       1550       1560
CVFGTCNNLP GMFHCICDDG YELDRTGGNC TDIDECADPI NCVNGLCVNT PGRYECNCPP
      1570       1580       1590       1600       1610       1620
DFQLNPTGVG CVDNRVGNCY LKFGPRGDGS LSCNTEIGVG VSRSSCCCSL GKAWGNPCET
      1630       1640       1650       1660       1670       1680
CPPVNSTEYY TLCPGGEGFR PNPITIILED IDECQELPGL CQGGNCINTF GSFQCECPQG
      1690       1700       1710       1720       1730       1740
YYLSEDTRIC EDIDECFAHP GVCGPGTCYN TLGNYTCICP PEYMQVNGGH NCMDMRKSFC
      1750       1760       1770       1780       1790       1800
YRSYNGTTCE NELPFNVTKR MCCCTYNVGK AWNKPCEPCP TPGTADFKTI CGNIPGFTFD
      1810       1820       1830       1840       1850       1860
IHTGKAVDID ECKEIPGICA NGVCINQIGS FRCECPTGFS YNDLLLVCED IDECSNGDNL
      1870       1880       1890       1900       1910       1920
CQRNADCINS PGSYRCECAA GFKLSPNGAC VDRNECLEIP NVCSHGLCVD LQGSYQCICH
      1930       1940       1950       1960       1970       1980
NGFKASQDQT MCMDVDECER HPCGNGTCKN TVGSYNCLCY PGFELTHNND CLDIDECSSF
      1990       2000       2010       2020       2030       2040
FGQVCRNGRC FNEIGSFKCL CNEGYELTPD GKNCIDTNEC VALPGSCSPG TCQNLEGSFR
      2050       2060       2070       2080       2090       2100
CICPPGYEVK SENCIDINEC DEDPNICLFG SCTNTPGGFQ CLCPPGFVLS DNGRRCFDTR
      2110       2120       2130       2140       2150       2160
QSFCFTNFEN GKCSVPKAFN TTKAKCCCSK MPGEGWGDPC ELCPKDDEVA FQDLCPYGHG
      2170       2180       2190       2200       2210       2220
TVPSLHDTRE DVNECLESPG ICSNGQCINT DGSFRCECPM GYNLDYTGVR CVDTDECSIG
      2230       2240       2250       2260       2270       2280
NPCGNGTCTN VIGSFECNCN EGFEPGPMMN CEDINECAQN PLLCAFRCMN TFGSYECTCP
      2290       2300       2310       2320       2330       2340
IGYALREDQK MCKDLDECAE GLHDCESRGM MCKNLIGTFM CICPPGMARR PDGEGCVDEN
      2350       2360       2370       2380       2390       2400
ECRTKPGICE NGRCVNIIGS YRCECNEGFQ SSSSGTECLD NRQGLCFAEV LQTICQMASS
      2410       2420       2430       2440       2450       2460
SRNLVTKSEC CCDGGRGWGH QCELCPLPGT AQYKKICPHG PGYTTDGRDI DECKVMPNLC
      2470       2480       2490       2500       2510       2520
TNGQCINTMG SFRCFCKVGY TTDISGTSCI DLDECSQSPK PCNYICKNTE GSYQCSCPRG
      2530       2540       2550       2560       2570       2580
YVLQEDGKTC KDLDECQTKQ HNCQFLCVNT LGGFTCKCPP GFTQHHTACI DNNECGSQPS
      2590       2600       2610       2620       2630       2640
LCGAKGICQN TPGSFSCECQ RGFSLDATGL NCEDVDECDG NHRCQHGCQN ILGGYRCGCP
      2650       2660       2670       2680       2690       2700
QGYIQHYQWN QCVDENECSN PNACGSASCY NTLGSYKCAC PSGFSFDQFS SACHDVNECS
      2710       2720       2730       2740       2750       2760
SSKNPCNYGC SNTEGGYLCG CPPGYYRVGQ GHCVSGMGFN KGQYLSLDTE VDEENALSPE
      2770       2780       2790       2800       2810       2820
ACYECKINGY SKKDSRQKRS IHEPDPTAVE QISLESVDMD SPVNMKFNLS HLGSKEHILE
      2830       2840       2850       2860       2870       2880
LRPAIQPLNN HIRYVISQGN DDSVFRIHQR NGLSYLHTAK KKLMPGTYTL EITSIPLYKK
      2890       2900       2910
KELKKLEESN EDDYLLGELG EALRMRLQIQ LY

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P35556-1-unknown	MGRRRR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74868
P35556-29-unknown	QPQPPP...	29	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P35556-29-unknown	QPQPPP...	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114481
P35556-488-unknown	LTILNQ...	488	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21404
P35556-488-unknown	LTILNQ...	488	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22963
P35556-488-unknown	LTILNQ...	488	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152841
P35556-489-unknown	TILNQT...	489	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21267
P35556-489-unknown	TILNQT...	489	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26408
P35556-489-unknown	TILNQT...	489	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22965
P35556-489-unknown	TILNQT...	489	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152858

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PIITGL	487	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21404
...PIITGL	487	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22963
...PIITGL	487	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136266
...IITGLT	488	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21267
...IITGLT	488	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26408
...IITGLT	488	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22965
...IITGLT	488	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136283
...QIQLY	2912	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP13_HUMAN	487	ITGL.\|.LTIL	inferred from experiment	unknown	MEROPS	Kielty CM	Hindson VJ et al.:Fibrillin degradation by matrix... (M10.009)	10386589,
MMP2_HUMAN	487	ITGL.\|.LTIL	inferred from experiment	unknown	MEROPS	Kielty CM	Hindson VJ et al.:Fibrillin degradation by matrix... (M10.009)	10386589,
MMP12_HUMAN	488	TGLT.\|.TILN	inferred from experiment	unknown	MEROPS	Kielty CM	Hindson VJ et al.:Fibrillin degradation by matrix... (M10.009)	10386589,
MMP9_HUMAN	488	TGLT.\|.TILN	inferred from experiment	unknown	MEROPS	Kielty CM	Hindson VJ et al.:Fibrillin degradation by matrix... (M10.009)	10386589,
MMP2_HUMAN	488	TGLT.\|.TILN	inferred from experiment	unknown	MEROPS	Kielty CM	Hindson VJ et al.:Fibrillin degradation by matrix... (M10.009)	10386589,

TopFIND

P35556: Fibrillin-2

General Information

4

N-termini

3

C-termini

5

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 5 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates