P21810: Biglycan

General Information

Protein names	- Biglycan - Bone/cartilage proteoglycan I - PG-S1
Gene names	BGN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P21810

20 N-termini

21 C-termini

29 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MWPLWRLVSL LALSQALPFE QRGFWDFTLD DGPFMMNDEE ASGADTSGVL DPDSVTPTYS
        70         80         90        100        110        120
AMCPFGCHCH LRVVQCSDLG LKSVPKEISP DTTLLDLQNN DISELRKDDF KGLQHLYALV
       130        140        150        160        170        180
LVNNKISKIH EKAFSPLRKL QKLYISKNHL VEIPPNLPSS LVELRIHDNR IRKVPKGVFS
       190        200        210        220        230        240
GLRNMNCIEM GGNPLENSGF EPGAFDGLKL NYLRISEAKL TGIPKDLPET LNELHLDHNK
       250        260        270        280        290        300
IQAIELEDLL RYSKLYRLGL GHNQIRMIEN GSLSFLPTLR ELHLDNNKLA RVPSGLPDLK
       310        320        330        340        350        360
LLQVVYLHSN NITKVGVNDF CPMGFGVKRA YYNGISLFNN PVPYWEVQPA TFRCVTDRLA

IQFGNYKK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

20 N-termini - 21 C-termini - 29 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P21810-20-unknown	EQRGFW...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P21810-38-unknown	DEEASG...	38	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P21810-38-unknown	DEEASG...	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31836
P21810-38-unknown	DEEASG...	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC677
P21810-81-unknown	LKSVPK...	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26403
P21810-81-unknown	LKSVPK...	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21393
P21810-82-unknown	KSVPKE...	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23890
P21810-83-unknown	SVPKEI...	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23891
P21810-105-unknown	LRKDDF...	105	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26404
P21810-105-unknown	LRKDDF...	105	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23892
P21810-105-unknown	LRKDDF...	105	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21394
P21810-178-unknown	VFSGLR...	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21395
P21810-187-unknown	CIEMGG...	187	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC372
P21810-187-unknown	CIEMGG...	187	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC452
P21810-197-unknown	NSGFEP...	197	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25089
P21810-197-unknown	NSGFEP...	197	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26405
P21810-212-unknown	YLRISE...	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25090
P21810-213-unknown	LRISEA...	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25091
P21810-213-unknown	LRISEA...	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21263
P21810-219-unknown	KLTGIP...	219	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23893
P21810-220-unknown	LTGIPK...	220	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21264
P21810-220-unknown	LTGIPK...	220	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26406
P21810-220-unknown	LTGIPK...	220	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23894
P21810-220-unknown	LTGIPK...	220	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21396
P21810-231-unknown	LNELHL...	231	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21265
P21810-236-unknown	LDHNKI...	236	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23895
P21810-246-unknown	LEDLLR...	246	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21397
P21810-282-unknown	LHLDNN...	282	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23896
P21810-296-unknown	LPDLKL...	296	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23897
P21810-329-unknown	RAYYNG...	329	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21398
P21810-344-unknown	YWEVQP...	344	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21399

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PFMMND	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31836
...PFMMND	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC677
...CSDLGL	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26403
...CSDLGL	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21393
...SDLGLK	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23890
...DLGLKS	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23891
...NDISEL	104	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26404
...NDISEL	104	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23892
...NDISEL	104	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21394
...KVPKGV	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21395
...LRNMNC	186	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC372
...LRNMNC	186	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC452
...GNPLEN	196	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25089
...GNPLEN	196	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26405
...GLKLNY	211	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25090
...LKLNYL	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25091
...LKLNYL	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21263
...RISEAK	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23893
...ISEAKL	219	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21264
...ISEAKL	219	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26406
...ISEAKL	219	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23894
...ISEAKL	219	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21396
...EAKLTG	221	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000402525
...EAKLTG	221	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000470463
...DLPETL	230	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21265
...LNELHL	235	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23895
...IQAIEL	245	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21397
...PTLREL	281	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23896
...RVPSGL	295	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23897
...GFGVKR	328	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21398
...NNPVPY	343	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21399
...GNYKK	368	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
TLL1_HUMAN	37	MMND.\|.DEEA	inferred from experiment	unknown	MEROPS	Greenspan DS	Scott IC et al.:Bone morphogenetic protein-1 pr... (M12.005)	10896944,
BMP1_HUMAN	37	MMND.\|.DEEA	inferred from experiment	unknown	MEROPS	Greenspan DS	Scott IC et al.:Bone morphogenetic protein-1 pr... (M12.005)	10896944,
MMP9_HUMAN	80	DLGL.\|.LKSV	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP13_HUMAN	80	DLGL.\|.LKSV	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP3_HUMAN	81	LGLK.\|.KSVP	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP3_HUMAN	82	GLKS.\|.SVPK	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP9_HUMAN	104	ISEL.\|.LRKD	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP3_HUMAN	104	ISEL.\|.LRKD	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP13_HUMAN	104	ISEL.\|.LRKD	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP13_HUMAN	177	PKGV.\|.VFSG	inferred from experiment	unknown	MEROPS	Martel-Pelletier J	Monfort J et al.:Degradation of small leucine-ri... (M10.013)	16507124,
ATS4_HUMAN	186	NMNC.\|.CIEM	inferred from experiment	unknown	MEROPS	Roughley PJ	Melching LI et al.:The cleavage of biglycan by agg... (M12.221)	16806997,
ATS5_HUMAN	186	NMNC.\|.CIEM	inferred from experiment	unknown	MEROPS	Roughley PJ	Melching LI et al.:The cleavage of biglycan by agg... (M12.221)	16806997,
MMP8_HUMAN	196	PLEN.\|.NSGF	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP9_HUMAN	196	PLEN.\|.NSGF	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP8_HUMAN	211	KLNY.\|.YLRI	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP8_HUMAN	212	LNYL.\|.LRIS	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP12_HUMAN	212	LNYL.\|.LRIS	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP3_HUMAN	218	SEAK.\|.KLTG	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP12_HUMAN	219	EAKL.\|.LTGI	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP9_HUMAN	219	EAKL.\|.LTGI	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP3_HUMAN	219	EAKL.\|.LTGI	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP13_HUMAN	219	EAKL.\|.LTGI	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP12_HUMAN	230	PETL.\|.LNEL	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP3_HUMAN	235	ELHL.\|.LDHN	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP13_HUMAN	245	AIEL.\|.LEDL	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP3_HUMAN	281	LREL.\|.LHLD	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP3_HUMAN	295	PSGL.\|.LPDL	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP13_HUMAN	328	GVKR.\|.RAYY	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP13_HUMAN	343	PVPY.\|.YWEV	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)