P13497: Bone morphogenetic protein 1

General Information

Protein names	- Bone morphogenetic protein 1 - BMP-1 - 3.4.24.19 - Mammalian tolloid protein - mTld - Procollagen C-proteinase - PCP
Gene names	BMP1
Organism	Homo sapiens
Protease Family	M12.005
Protease ID	M12.005
Chromosome location
UniProt ID	P13497

3 N-termini

2 C-termini

6 Cleavages

60 Substrates

Sequence

Isoforms

- Isoform BMP1-1 of Bone morphogenetic protein 1 - Isoform BMP1-4 of Bone morphogenetic protein 1 - Isoform BMP1-5 of Bone morphogenetic protein 1 - Isoform BMP1-6 of Bone morphogenetic protein 1 - Isoform BMP1-7 of Bone morphogenetic protein 1

Sequence View

        10         20         30         40         50         60
MPGVARLPLL LGLLLLPRPG RPLDLADYTY DLAEEDDSEP LNYKDPCKAA AFLGDIALDE
        70         80         90        100        110        120
EDLRAFQVQQ AVDLRRHTAR KSSIKAAVPG NTSTPSCQST NGQPQRGACG RWRGRSRSRR
       130        140        150        160        170        180
AATSRPERVW PDGVIPFVIG GNFTGSQRAV FRQAMRHWEK HTCVTFLERT DEDSYIVFTY
       190        200        210        220        230        240
RPCGCCSYVG RRGGGPQAIS IGKNCDKFGI VVHELGHVVG FWHEHTRPDR DRHVSIVREN
       250        260        270        280        290        300
IQPGQEYNFL KMEPQEVESL GETYDFDSIM HYARNTFSRG IFLDTIVPKY EVNGVKPPIG
       310        320        330        340        350        360
QRTRLSKGDI AQARKLYKCP ACGETLQDST GNFSSPEYPN GYSAHMHCVW RISVTPGEKI
       370        380        390        400        410        420
ILNFTSLDLY RSRLCWYDYV EVRDGFWRKA PLRGRFCGSK LPEPIVSTDS RLWVEFRSSS
       430        440        450        460        470        480
NWVGKGFFAV YEAICGGDVK KDYGHIQSPN YPDDYRPSKV CIWRIQVSEG FHVGLTFQSF
       490        500        510        520        530        540
EIERHDSCAY DYLEVRDGHS ESSTLIGRYC GYEKPDDIKS TSSRLWLKFV SDGSINKAGF
       550        560        570        580        590        600
AVNFFKEVDE CSRPNRGGCE QRCLNTLGSY KCSCDPGYEL APDKRRCEAA CGGFLTKLNG
       610        620        630        640        650        660
SITSPGWPKE YPPNKNCIWQ LVAPTQYRIS LQFDFFETEG NDVCKYDFVE VRSGLTADSK
       670        680        690        700        710        720
LHGKFCGSEK PEVITSQYNN MRVEFKSDNT VSKKGFKAHF FSDKDECSKD NGGCQQDCVN
       730        740        750        760        770        780
TFGSYECQCR SGFVLHDNKH DCKEAGCDHK VTSTSGTITS PNWPDKYPSK KECTWAISST
       790        800        810        820        830        840
PGHRVKLTFM EMDIESQPEC AYDHLEVFDG RDAKAPVLGR FCGSKKPEPV LATGSRMFLR
       850        860        870        880        890        900
FYSDNSVQRK GFQASHATEC GGQVRADVKT KDLYSHAQFG DNNYPGGVDC EWVIVAEEGY
       910        920        930        940        950        960
GVELVFQTFE VEEETDCGYD YMELFDGYDS TAPRLGRYCG SGPPEEVYSA GDSVLVKFHS
       970        980
DDTITKKGFH LRYTSTKFQD TLHSRK         10         20         30         40         50         60
MPGVARLPLL LGLLLLPRPG RPLDLADYTY DLAEEDDSEP LNYKDPCKAA AFLGDIALDE
        70         80         90        100        110        120
EDLRAFQVQQ AVDLRRHTAR KSSIKAAVPG NTSTPSCQST NGQPQRGACG RWRGRSRSRR
       130        140        150        160        170        180
AATSRPERVW PDGVIPFVIG GNFTGSQRAV FRQAMRHWEK HTCVTFLERT DEDSYIVFTY
       190        200        210        220        230        240
RPCGCCSYVG RRGGGPQAIS IGKNCDKFGI VVHELGHVVG FWHEHTRPDR DRHVSIVREN
       250        260        270        280        290        300
IQPGQEYNFL KMEPQEVESL GETYDFDSIM HYARNTFSRG IFLDTIVPKY EVNGVKPPIG
       310        320        330        340        350        360
QRTRLSKGDI AQARKLYKCP ACGETLQDST GNFSSPEYPN GYSAHMHCVW RISVTPGEKI
       370        380        390        400        410        420
ILNFTSLDLY RSRLCWYDYV EVRDGFWRKA PLRGRFCGSK LPEPIVSTDS RLWVEFRSSS
       430        440        450        460        470        480
NWVGKGFFAV YEAICGGDVK KDYGHIQSPN YPDDYRPSKV CIWRIQVSEG FHVGLTFQSF
       490        500        510        520        530        540
EIERHDSCAY DYLEVRDGHS ESSTLIGRYC GYEKPDDIKS TSSRLWLKFV SDGSINKAGF
       550        560        570        580        590        600
AVNFFKEVDE CSRPNRGGCE QRCLNTLGSY KCSCDPGYEL APDKRRCEAA CGGFLTKLNG
       610        620        630        640        650        660
SITSPGWPKE YPPNKNCIWQ LVAPTQYRIS LQFDFFETEG NDVCKYDFVE VRSGLTADSK
       670        680        690        700        710        720
LHGKFCGSEK PEVITSQYNN MRVEFKSDNT VSKKGFKAHF FSDKDECSKD NGGCQQDCVN
       730        740        750        760        770        780
TFGSYECQCR SGFVLHDNKH DCKEAGCDHK VTSTSGTITS PNWPDKYPSK KECTWAISST
       790        800        810        820        830        840
PGHRVKLTFM EMDIESQPEC AYDHLEVFDG RDAKAPVLGR FCGSKKPEPV LATGSRMFLR
       850        860        870        880        890        900
FYSDNSVQRK GFQASHATEC GGQVRADVKT KDLYSHAQFG DNNYPGGVDC EWVIVAEEGY
       910        920        930        940        950        960
GVELVFQTFE VEEETDCGYD YMELFDGYDS TAPRLGRYCG SGPPEEVYSA GDSVLVKFHS
       970        980
DDTITKKGFH LRYTSTKFQD TLHSRK         10         20         30         40         50         60
MPGVARLPLL LGLLLLPRPG RPLDLADYTY DLAEEDDSEP LNYKDPCKAA AFLGDIALDE
        70         80         90        100        110        120
EDLRAFQVQQ AVDLRRHTAR KSSIKAAVPG NTSTPSCQST NGQPQRGACG RWRGRSRSRR
       130        140        150        160        170        180
AATSRPERVW PDGVIPFVIG GNFTGSQRAV FRQAMRHWEK HTCVTFLERT DEDSYIVFTY
       190        200        210        220        230        240
RPCGCCSYVG RRGGGPQAIS IGKNCDKFGI VVHELGHVVG FWHEHTRPDR DRHVSIVREN
       250        260        270        280        290        300
IQPGQEYNFL KMEPQEVESL GETYDFDSIM HYARNTFSRG IFLDTIVPKY EVNGVKPPIG
       310        320        330        340        350        360
QRTRLSKGDI AQARKLYKCP ACGETLQDST GNFSSPEYPN GYSAHMHCVW RISVTPGEKI
       370        380        390        400        410        420
ILNFTSLDLY RSRLCWYDYV EVRDGFWRKA PLRGRFCGSK LPEPIVSTDS RLWVEFRSSS
       430        440        450        460        470        480
NWVGKGFFAV YEAICGGDVK KDYGHIQSPN YPDDYRPSKV CIWRIQVSEG FHVGLTFQSF
       490        500        510        520        530        540
EIERHDSCAY DYLEVRDGHS ESSTLIGRYC GYEKPDDIKS TSSRLWLKFV SDGSINKAGF
       550        560        570        580        590        600
AVNFFKEVDE CSRPNRGGCE QRCLNTLGSY KCSCDPGYEL APDKRRCEAA CGGFLTKLNG
       610        620        630        640        650        660
SITSPGWPKE YPPNKNCIWQ LVAPTQYRIS LQFDFFETEG NDVCKYDFVE VRSGLTADSK
       670        680        690        700        710        720
LHGKFCGSEK PEVITSQYNN MRVEFKSDNT VSKKGFKAHF FSDKDECSKD NGGCQQDCVN
       730        740        750        760        770        780
TFGSYECQCR SGFVLHDNKH DCKEAGCDHK VTSTSGTITS PNWPDKYPSK KECTWAISST
       790        800        810        820        830        840
PGHRVKLTFM EMDIESQPEC AYDHLEVFDG RDAKAPVLGR FCGSKKPEPV LATGSRMFLR
       850        860        870        880        890        900
FYSDNSVQRK GFQASHATEC GGQVRADVKT KDLYSHAQFG DNNYPGGVDC EWVIVAEEGY
       910        920        930        940        950        960
GVELVFQTFE VEEETDCGYD YMELFDGYDS TAPRLGRYCG SGPPEEVYSA GDSVLVKFHS
       970        980
DDTITKKGFH LRYTSTKFQD TLHSRK         10         20         30         40         50         60
MPGVARLPLL LGLLLLPRPG RPLDLADYTY DLAEEDDSEP LNYKDPCKAA AFLGDIALDE
        70         80         90        100        110        120
EDLRAFQVQQ AVDLRRHTAR KSSIKAAVPG NTSTPSCQST NGQPQRGACG RWRGRSRSRR
       130        140        150        160        170        180
AATSRPERVW PDGVIPFVIG GNFTGSQRAV FRQAMRHWEK HTCVTFLERT DEDSYIVFTY
       190        200        210        220        230        240
RPCGCCSYVG RRGGGPQAIS IGKNCDKFGI VVHELGHVVG FWHEHTRPDR DRHVSIVREN
       250        260        270        280        290        300
IQPGQEYNFL KMEPQEVESL GETYDFDSIM HYARNTFSRG IFLDTIVPKY EVNGVKPPIG
       310        320        330        340        350        360
QRTRLSKGDI AQARKLYKCP ACGETLQDST GNFSSPEYPN GYSAHMHCVW RISVTPGEKI
       370        380        390        400        410        420
ILNFTSLDLY RSRLCWYDYV EVRDGFWRKA PLRGRFCGSK LPEPIVSTDS RLWVEFRSSS
       430        440        450        460        470        480
NWVGKGFFAV YEAICGGDVK KDYGHIQSPN YPDDYRPSKV CIWRIQVSEG FHVGLTFQSF
       490        500        510        520        530        540
EIERHDSCAY DYLEVRDGHS ESSTLIGRYC GYEKPDDIKS TSSRLWLKFV SDGSINKAGF
       550        560        570        580        590        600
AVNFFKEVDE CSRPNRGGCE QRCLNTLGSY KCSCDPGYEL APDKRRCEAA CGGFLTKLNG
       610        620        630        640        650        660
SITSPGWPKE YPPNKNCIWQ LVAPTQYRIS LQFDFFETEG NDVCKYDFVE VRSGLTADSK
       670        680        690        700        710        720
LHGKFCGSEK PEVITSQYNN MRVEFKSDNT VSKKGFKAHF FSDKDECSKD NGGCQQDCVN
       730        740        750        760        770        780
TFGSYECQCR SGFVLHDNKH DCKEAGCDHK VTSTSGTITS PNWPDKYPSK KECTWAISST
       790        800        810        820        830        840
PGHRVKLTFM EMDIESQPEC AYDHLEVFDG RDAKAPVLGR FCGSKKPEPV LATGSRMFLR
       850        860        870        880        890        900
FYSDNSVQRK GFQASHATEC GGQVRADVKT KDLYSHAQFG DNNYPGGVDC EWVIVAEEGY
       910        920        930        940        950        960
GVELVFQTFE VEEETDCGYD YMELFDGYDS TAPRLGRYCG SGPPEEVYSA GDSVLVKFHS
       970        980
DDTITKKGFH LRYTSTKFQD TLHSRK         10         20         30         40         50         60
MPGVARLPLL LGLLLLPRPG RPLDLADYTY DLAEEDDSEP LNYKDPCKAA AFLGDIALDE
        70         80         90        100        110        120
EDLRAFQVQQ AVDLRRHTAR KSSIKAAVPG NTSTPSCQST NGQPQRGACG RWRGRSRSRR
       130        140        150        160        170        180
AATSRPERVW PDGVIPFVIG GNFTGSQRAV FRQAMRHWEK HTCVTFLERT DEDSYIVFTY
       190        200        210        220        230        240
RPCGCCSYVG RRGGGPQAIS IGKNCDKFGI VVHELGHVVG FWHEHTRPDR DRHVSIVREN
       250        260        270        280        290        300
IQPGQEYNFL KMEPQEVESL GETYDFDSIM HYARNTFSRG IFLDTIVPKY EVNGVKPPIG
       310        320        330        340        350        360
QRTRLSKGDI AQARKLYKCP ACGETLQDST GNFSSPEYPN GYSAHMHCVW RISVTPGEKI
       370        380        390        400        410        420
ILNFTSLDLY RSRLCWYDYV EVRDGFWRKA PLRGRFCGSK LPEPIVSTDS RLWVEFRSSS
       430        440        450        460        470        480
NWVGKGFFAV YEAICGGDVK KDYGHIQSPN YPDDYRPSKV CIWRIQVSEG FHVGLTFQSF
       490        500        510        520        530        540
EIERHDSCAY DYLEVRDGHS ESSTLIGRYC GYEKPDDIKS TSSRLWLKFV SDGSINKAGF
       550        560        570        580        590        600
AVNFFKEVDE CSRPNRGGCE QRCLNTLGSY KCSCDPGYEL APDKRRCEAA CGGFLTKLNG
       610        620        630        640        650        660
SITSPGWPKE YPPNKNCIWQ LVAPTQYRIS LQFDFFETEG NDVCKYDFVE VRSGLTADSK
       670        680        690        700        710        720
LHGKFCGSEK PEVITSQYNN MRVEFKSDNT VSKKGFKAHF FSDKDECSKD NGGCQQDCVN
       730        740        750        760        770        780
TFGSYECQCR SGFVLHDNKH DCKEAGCDHK VTSTSGTITS PNWPDKYPSK KECTWAISST
       790        800        810        820        830        840
PGHRVKLTFM EMDIESQPEC AYDHLEVFDG RDAKAPVLGR FCGSKKPEPV LATGSRMFLR
       850        860        870        880        890        900
FYSDNSVQRK GFQASHATEC GGQVRADVKT KDLYSHAQFG DNNYPGGVDC EWVIVAEEGY
       910        920        930        940        950        960
GVELVFQTFE VEEETDCGYD YMELFDGYDS TAPRLGRYCG SGPPEEVYSA GDSVLVKFHS
       970        980
DDTITKKGFH LRYTSTKFQD TLHSRK

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P13497-1-unknown	MPGVAR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68533
P13497-1-unknown	MPGVAR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68534
P13497-1-unknown	MPGVAR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68535
P13497-1-unknown	MPGVAR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68536
P13497-1-unknown	MPGVAR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68537
P13497-23-unknown	LDLADY...	23	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P13497-23-unknown	LDLADY...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113245
P13497-23-unknown	LDLADY...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113246
P13497-23-unknown	LDLADY...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113247
P13497-23-unknown	LDLADY...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113248
P13497-23-unknown	LDLADY...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113249
P13497-121-unknown	AATSRP...	121	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P13497-121-unknown	AATSRP...	121	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9735
P13497-121-unknown	AATSRP...	121	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27154
P13497-121-unknown	AATSRP...	121	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27007
P13497-121-unknown	AATSRP...	121	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27306
P13497-121-unknown	AATSRP...	121	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26595
P13497-121-unknown	AATSRP...	121	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26862
P13497-121-unknown	AATSRP...	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115908
P13497-121-unknown	AATSRP...	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115909
P13497-121-unknown	AATSRP...	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115910
P13497-121-unknown	AATSRP...	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115911
P13497-121-unknown	AATSRP...	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115912

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SRSRRA	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9735
...SRSRRA	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27154
...SRSRRA	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27007
...SRSRRA	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27306
...SRSRRA	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26595
...SRSRRA	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26862
...SRSRRA	120	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126733
...SRSRRA	120	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126735
...SRSRRA	120	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126736
...SRSRRA	120	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126737
...SRSRRA	120	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126738
...LHSRK	986	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FURIN_HUMAN	120	SRRA.\|.AATS	inferred from experiment	unknown	MEROPS	Kadler KE	Leighton M et al.:Paired basic/Furin-like proprot... (S08.071)	12637569,
PCSK6_HUMAN	120	SRRA.\|.AATS	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK5_HUMAN	120	SRRA.\|.AATS	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	120	SRRA.\|.AATS	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
NEC2_HUMAN	120	SRRA.\|.AATS	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	120	SRRA.\|.AATS	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CO2A1-Isoform3_HUMAN	22	MRAD.\|.DQAA	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC649
APOA1_HUMAN	24	WQQD.\|.DEPP	inferred from experiment	unknown	MEROPS	Fielding CJ	Chau P et al.:Bone morphogenetic protein-1 (B... (M12.005)	17580958,
PGS2_HUMAN	30	MLED.\|.DEAS	inferred from experiment	unknown	MEROPS	Greenspan DS	Scott IC et al.:Bone morphogenetic protein-1 pr... (M12.005)	10896944,
PGS2-Isoform5_HUMAN	30	MLED.\|.DEAS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC656
PGS2-Isoform4_HUMAN	30	MLED.\|.DEAS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC656
PGS2-Isoform3_HUMAN	30	MLED.\|.DEAS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC656
PGS2-Isoform2_HUMAN	30	MLED.\|.DEAS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC656
PGS1_HUMAN	37	MMND.\|.DEEA	inferred from experiment	unknown	MEROPS	Greenspan DS	Scott IC et al.:Bone morphogenetic protein-1 pr... (M12.005)	10896944,
LOXL3-Isoform2_HUMAN	86	ICGD.\|.DDWG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC680
SOMA-Isoform4_HUMAN	132	SHND.\|.DDAL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC643
SOMA-Isoform5_HUMAN	138	SHND.\|.DDAL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC643
SOMA-Isoform3_HUMAN	140	SHND.\|.DDAL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC643
CHRD_HUMAN	153	SYSD.\|.DRGE	inferred from experiment	unknown	MEROPS	Greenspan DS	Scott IC et al.:Bone morphogenetic protein-1 pr... (M12.005)	10896944,
CHRD-Isoform5_HUMAN	153	SYSD.\|.DRGE	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC696
CHRD-Isoform4_HUMAN	153	SYSD.\|.DRGE	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC696
SOMA-Isoform2_HUMAN	163	SHND.\|.DDAL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC643
LYOX_HUMAN	168	MVGD.\|.DDPY	inferred from experiment	unknown	MEROPS	Trackman PC	Uzel MI et al.:Multiple bone morphogenetic pro... (M12.005)	11313359,
SOMA_HUMAN	178	SHND.\|.DDAL	inferred from experiment	unknown	MEROPS	Greenspan DS	Ge G et al.:Bone morphogenetic protein 1 pr... (M12.005)	17548836,
PRL_HUMAN	187	QMAD.\|.DEES	inferred from experiment	unknown	MEROPS	Greenspan DS	Ge G et al.:Bone morphogenetic protein 1 pr... (M12.005)	17548836,
IBP3_HUMAN	194	SQST.\|.TDTQ	inferred from experiment	unknown	MEROPS	Greenspan DS	Kim B et al.:Bone morphogenetic protein-1 pr... (M12.005)	21697095,
IBP3-Isoform2_HUMAN	200	SQST.\|.TDTQ	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC673
COBA2_HUMAN	238	PQNQ.\|.QQPH	inferred from experiment	unknown	MEROPS	Oxford JT	Medeck RJ et al.:BMP-1-mediated proteolytic proc... (M12.005)	12962540,
COBA2-Isoform9_HUMAN	238	PQNQ.\|.QQPH	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC664
COBA2-Isoform8_HUMAN	238	PQNQ.\|.QQPH	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC664
COBA2-Isoform7_HUMAN	238	PQNQ.\|.QQPH	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC664
COBA2-Isoform6_HUMAN	238	PQNQ.\|.QQPH	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC664
COBA2-Isoform5_HUMAN	238	PQNQ.\|.QQPH	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC664
COBA2-Isoform4_HUMAN	238	PQNQ.\|.QQPH	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC664
COBA2-Isoform3_HUMAN	238	PQNQ.\|.QQPH	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC664
COBA2-Isoform2_HUMAN	238	PQNQ.\|.QQPH	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC664
COBA1_HUMAN	253	AQAQ.\|.QEPQ	inferred from experiment	unknown	MEROPS	Oxford JT	Medeck RJ et al.:BMP-1-mediated proteolytic proc... (M12.005)	12962540,
COBA1-Isoform4_HUMAN	253	AQAQ.\|.QEPQ	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC662
CO5A1_HUMAN	254	PQSQ.\|.QDPN	inferred from experiment	unknown	MEROPS	Ruggiero F	Bonod-Bidaud C et al.:Enzymatic cleavage specificity ... (M12.005)	17407447,
LOXL3-Isoform3_HUMAN	302	ICGD.\|.DDWG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC680
LTBP1-Isoform3_HUMAN	432	PSLD.\|.DQEK	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC686
LOXL3_HUMAN	447	ICGD.\|.DDWG	inferred from experiment	unknown	MEROPS	Kim Y	Lee JE et al.:A tissue-specific variant of th... (M12.005)	17018530,
CO5A3_HUMAN	463	FQQA.\|.AQAQ	inferred from experiment	unknown	MEROPS		Merops BMP1_HUMAN -> CO5A3_HUMAN @463
CO5A3_HUMAN	463	FQQA.\|.AQAQ	inferred from experiment	unknown	MEROPS	Greenspan DS	Gopalakrishnan B et al.:Biosynthetic processing of the ... (M12.005)	15136578,
LTBP1-Isoform5_HUMAN	485	PSLD.\|.DQEK	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC686
LTBP1-Isoform2_HUMAN	485	PSLD.\|.DQEK	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC686
A2MG_HUMAN	710	YESD.\|.DVMG	inferred from experiment	unknown	MEROPS	Greenspan DS	Zhang Y et al.:Inhibition of bone morphogeneti... (M12.005)	17071617,
LTBP1_HUMAN	811	PSLD.\|.DQEK	inferred from experiment	unknown	MEROPS	Greenspan DS	Ge G et al.:BMP1 controls TGFbeta1 activati... (M12.005)	17015622,
LTBP1-Isoform4_HUMAN	811	PSLD.\|.DQEK	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC686
CHRD-Isoform5_HUMAN	826	MQAD.\|.DGPR	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC699
CHRD_HUMAN	866	MQAD.\|.DGPR	inferred from experiment	unknown	MEROPS	Greenspan DS	Scott IC et al.:Bone morphogenetic protein-1 pr... (M12.005)	10896944,
CO3A1-Isoform2_HUMAN	918	YYGD.\|.DEPM	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC652
CO1A2_HUMAN	1119	YRAD.\|.DQPR	inferred from experiment	unknown	MEROPS	Greenspan DS	Scott IC et al.:Bone morphogenetic protein-1 pr... (M12.005)	10896944,
CO2A1-Isoform1_HUMAN	1172	MRAD.\|.DQAA	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC649
CO1A1_HUMAN	1218	YRAD.\|.DDAN	inferred from experiment	unknown	MEROPS	Graham MF	Kofford MW et al.:Cleavage of type I procollagen ... (M12.005)	9054407,
CO1A1_HUMAN	1218	YRAD.\|.DDAN	inferred from experiment	unknown	MEROPS		Merops BMP1_HUMAN -> CO1A1_HUMAN @1218
CO3A1_HUMAN	1221	YYGD.\|.DEPM	inferred from experiment	unknown	MEROPS	Greenspan DS	Scott IC et al.:Bone morphogenetic protein-1 pr... (M12.005)	10896944,
LTBP1-Isoform3_HUMAN	1231	FIQD.\|.DRFL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC691
CO2A1_HUMAN	1241	MRAD.\|.DQAA	inferred from experiment	unknown	MEROPS		Merops BMP1_HUMAN -> CO2A1_HUMAN @1241
CO5A2_HUMAN	1253	FTED.\|.DQAA	inferred from experiment	unknown	MEROPS	Greenspan DS	Unsold C et al.:Biosynthetic processing of the ... (M12.005)	11741999,
LTBP1-Isoform2_HUMAN	1284	FIQD.\|.DRFL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC691
LTBP1-Isoform5_HUMAN	1285	FIQD.\|.DRFL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC691
CO5A1_HUMAN	1594	LLDD.\|.DGNG	inferred from experiment	unknown	MEROPS	Greenspan DS	Unsold C et al.:Biosynthetic processing of the ... (M12.005)	11741999,
LTBP1_HUMAN	1610	FIQD.\|.DRFL	inferred from experiment	unknown	MEROPS	Greenspan DS	Ge G et al.:BMP1 controls TGFbeta1 activati... (M12.005)	17015622,
LTBP1-Isoform4_HUMAN	1611	FIQD.\|.DRFL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC691
CO7A1-Isoform2_HUMAN	2789	YAAD.\|.DTAG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC684
CO7A1_HUMAN	2821	YAAD.\|.DTAG	inferred from experiment	unknown	MEROPS	Bruckner-Tuderman L	Rattenholl A et al.:Proteinases of the bone morphog... (M12.005)	11986329,
PGBM_HUMAN	4196	GGND.\|.DAPG	inferred from experiment	unknown	MEROPS	Iozzo RV	Gonzalez EM et al.:BMP-1/Tolloid-like metalloprote... (M12.005)	15591058,

TopFIND

P13497: Bone morphogenetic protein 1

General Information

3

N-termini

2

C-termini

6

Cleavages

60

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 6 Cleavages - 60 Substrates

N-termini

C-termini

Cleavages

Substrates