P01236: Prolactin

General Information

Protein names	- Prolactin - PRL
Gene names	PRL
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P01236

8 N-termini

8 C-termini

16 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNIKGSPWKG SLLLLLVSNL LLCQSVAPLP ICPGGAARCQ VTLRDLFDRA VVLSHYIHNL
        70         80         90        100        110        120
SSEMFSEFDK RYTHGRGFIT KAINSCHTSS LATPEDKEQA QQMNQKDFLS LIVSILRSWN
       130        140        150        160        170        180
EPLYHLVTEV RGMQEAPEAI LSKAVEIEEQ TKRLLEGMEL IVSQVHPETK ENEIYPVWSG
       190        200        210        220
LPSLQMADEE SRLSAYYNLL HCLRRDSHKI DNYLKLLKCR IIHNNNC

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 8 C-termini - 16 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P01236-29-unknown	LPICPG...	29	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01236-82-unknown	AINSCH...	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21718
P01236-82-unknown	AINSCH...	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31738
P01236-140-unknown	ILSKAV...	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25111
P01236-140-unknown	ILSKAV...	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22091
P01236-140-unknown	ILSKAV...	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23662
P01236-140-unknown	ILSKAV...	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21719
P01236-161-unknown	IVSQVH...	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4339
P01236-176-unknown	PVWSGL...	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4340
P01236-179-unknown	SGLPSL...	179	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4341
P01236-185-unknown	QMADEE...	185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25112
P01236-185-unknown	QMADEE...	185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21285
P01236-185-unknown	QMADEE...	185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22092
P01236-185-unknown	QMADEE...	185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23663
P01236-185-unknown	QMADEE...	185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21720
P01236-185-unknown	QMADEE...	185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24800
P01236-188-unknown	DEESRL...	188	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC642

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GFITKA	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21718
...GFITKA	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31738
...EAPEAI	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25111
...EAPEAI	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22091
...EAPEAI	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23662
...EAPEAI	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21719
...EGMELI	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4339
...ENEIYP	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4340
...IYPVWS	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4341
...GLPSLQ	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25112
...GLPSLQ	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21285
...GLPSLQ	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22092
...GLPSLQ	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23663
...GLPSLQ	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21720
...GLPSLQ	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24800
...SLQMAD	187	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC642
...HNNNC	227	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP1_HUMAN	81	ITKA.\|.AINS	inferred from experiment	unknown	MEROPS	Clapp C	Macotela Y et al.:Matrix metalloproteases from ch... (M10.013)	16608881,
THRB_HUMAN	81	ITKA.\|.AINS	inferred from experiment	unknown	MEROPS	Ben-Jonathan N	Khurana S et al.:Proteolysis of human prolactin:... (S01.217)	10465285,
MMP9_HUMAN	139	PEAI.\|.ILSK	inferred from experiment	unknown	MEROPS	Clapp C	Macotela Y et al.:Matrix metalloproteases from ch... (M10.013)	16608881,
MMP2_HUMAN	139	PEAI.\|.ILSK	inferred from experiment	unknown	MEROPS	Clapp C	Macotela Y et al.:Matrix metalloproteases from ch... (M10.013)	16608881,
MMP3_HUMAN	139	PEAI.\|.ILSK	inferred from experiment	unknown	MEROPS	Clapp C	Macotela Y et al.:Matrix metalloproteases from ch... (M10.013)	16608881,
MMP1_HUMAN	139	PEAI.\|.ILSK	inferred from experiment	unknown	MEROPS	Clapp C	Macotela Y et al.:Matrix metalloproteases from ch... (M10.013)	16608881,
CATD_HUMAN	160	MELI.\|.IVSQ	inferred from experiment	unknown	MEROPS	Goffin V	Piwnica D et al.:Cathepsin D processes human pro... (A01.009)	15192082,
CATD_HUMAN	175	EIYP.\|.PVWS	inferred from experiment	unknown	MEROPS	Goffin V	Piwnica D et al.:Cathepsin D processes human pro... (A01.009)	15192082,
CATD_HUMAN	178	PVWS.\|.SGLP	inferred from experiment	unknown	MEROPS	Goffin V	Piwnica D et al.:Cathepsin D processes human pro... (A01.009)	15192082,
MMP9_HUMAN	184	PSLQ.\|.QMAD	inferred from experiment	unknown	MEROPS	Clapp C	Macotela Y et al.:Matrix metalloproteases from ch... (M10.013)	16608881,
MMP13_HUMAN	184	PSLQ.\|.QMAD	inferred from experiment	unknown	MEROPS	Clapp C	Macotela Y et al.:Matrix metalloproteases from ch... (M10.013)	16608881,
MMP2_HUMAN	184	PSLQ.\|.QMAD	inferred from experiment	unknown	MEROPS	Clapp C	Macotela Y et al.:Matrix metalloproteases from ch... (M10.013)	16608881,
MMP3_HUMAN	184	PSLQ.\|.QMAD	inferred from experiment	unknown	MEROPS	Clapp C	Macotela Y et al.:Matrix metalloproteases from ch... (M10.013)	16608881,
MMP1_HUMAN	184	PSLQ.\|.QMAD	inferred from experiment	unknown	MEROPS	Clapp C	Macotela Y et al.:Matrix metalloproteases from ch... (M10.013)	16608881,
MMP8_HUMAN	184	PSLQ.\|.QMAD	inferred from experiment	unknown	MEROPS	Clapp C	Macotela Y et al.:Matrix metalloproteases from ch... (M10.013)	16608881,
BMP1_HUMAN	187	QMAD.\|.DEES	inferred from experiment	unknown	MEROPS	Greenspan DS	Ge G et al.:Bone morphogenetic protein 1 pr... (M12.005)	17548836,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)