P02452: Collagen alpha-1(I) chain

General Information

Protein names	- Collagen alpha-1(I) chain - Alpha-1 type I collagen
Gene names	COL1A1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P02452

9 N-termini

8 C-termini

12 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MFSFVDLRLL LLLAATALLT HGQEEGQVEG QDEDIPPITC VQNGLRYHDR DVWKPEPCRI
        70         80         90        100        110        120
CVCDNGKVLC DDVICDETKN CPGAEVPEGE CCPVCPDGSE SPTDQETTGV EGPKGDTGPR
       130        140        150        160        170        180
GPRGPAGPPG RDGIPGQPGL PGPPGPPGPP GPPGLGGNFA PQLSYGYDEK STGGISVPGP
       190        200        210        220        230        240
MGPSGPRGLP GPPGAPGPQG FQGPPGEPGE PGASGPMGPR GPPGPPGKNG DDGEAGKPGR
       250        260        270        280        290        300
PGERGPPGPQ GARGLPGTAG LPGMKGHRGF SGLDGAKGDA GPAGPKGEPG SPGENGAPGQ
       310        320        330        340        350        360
MGPRGLPGER GRPGAPGPAG ARGNDGATGA AGPPGPTGPA GPPGFPGAVG AKGEAGPQGP
       370        380        390        400        410        420
RGSEGPQGVR GEPGPPGPAG AAGPAGNPGA DGQPGAKGAN GAPGIAGAPG FPGARGPSGP
       430        440        450        460        470        480
QGPGGPPGPK GNSGEPGAPG SKGDTGAKGE PGPVGVQGPP GPAGEEGKRG ARGEPGPTGL
       490        500        510        520        530        540
PGPPGERGGP GSRGFPGADG VAGPKGPAGE RGSPGPAGPK GSPGEAGRPG EAGLPGAKGL
       550        560        570        580        590        600
TGSPGSPGPD GKTGPPGPAG QDGRPGPPGP PGARGQAGVM GFPGPKGAAG EPGKAGERGV
       610        620        630        640        650        660
PGPPGAVGPA GKDGEAGAQG PPGPAGPAGE RGEQGPAGSP GFQGLPGPAG PPGEAGKPGE
       670        680        690        700        710        720
QGVPGDLGAP GPSGARGERG FPGERGVQGP PGPAGPRGAN GAPGNDGAKG DAGAPGAPGS
       730        740        750        760        770        780
QGAPGLQGMP GERGAAGLPG PKGDRGDAGP KGADGSPGKD GVRGLTGPIG PPGPAGAPGD
       790        800        810        820        830        840
KGESGPSGPA GPTGARGAPG DRGEPGPPGP AGFAGPPGAD GQPGAKGEPG DAGAKGDAGP
       850        860        870        880        890        900
PGPAGPAGPP GPIGNVGAPG AKGARGSAGP PGATGFPGAA GRVGPPGPSG NAGPPGPPGP
       910        920        930        940        950        960
AGKEGGKGPR GETGPAGRPG EVGPPGPPGP AGEKGSPGAD GPAGAPGTPG PQGIAGQRGV
       970        980        990       1000       1010       1020
VGLPGQRGER GFPGLPGPSG EPGKQGPSGA SGERGPPGPM GPPGLAGPPG ESGREGAPGA
      1030       1040       1050       1060       1070       1080
EGSPGRDGSP GAKGDRGETG PAGPPGAPGA PGAPGPVGPA GKSGDRGETG PAGPTGPVGP
      1090       1100       1110       1120       1130       1140
VGARGPAGPQ GPRGDKGETG EQGDRGIKGH RGFSGLQGPP GPPGSPGEQG PSGASGPAGP
      1150       1160       1170       1180       1190       1200
RGPPGSAGAP GKDGLNGLPG PIGPPGPRGR TGDAGPVGPP GPPGPPGPPG PPSAGFDFSF
      1210       1220       1230       1240       1250       1260
LPQPPQEKAH DGGRYYRADD ANVVRDRDLE VDTTLKSLSQ QIENIRSPEG SRKNPARTCR
      1270       1280       1290       1300       1310       1320
DLKMCHSDWK SGEYWIDPNQ GCNLDAIKVF CNMETGETCV YPTQPSVAQK NWYISKNPKD
      1330       1340       1350       1360       1370       1380
KRHVWFGESM TDGFQFEYGG QGSDPADVAI QLTFLRLMST EASQNITYHC KNSVAYMDQQ
      1390       1400       1410       1420       1430       1440
TGNLKKALLL QGSNEIEIRA EGNSRFTYSV TVDGCTSHTG AWGKTVIEYK TTKTSRLPII
      1450       1460
DVAPLDVGAP DQEFGFDVGP VCFL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 8 C-termini - 12 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P02452-162-unknown	QLSYGY...	162		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC308
P02452-162-Pyrrolidone carboxylic acid	QLSYGY...	162	pyrrolidone carboxylic acid-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P02452-264-unknown	MKGHRG...	264		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4987
P02452-954-unknown	IAGQRG...	954		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21286
P02452-954-unknown	IAGQRG...	954		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22094
P02452-954-unknown	IAGQRG...	954		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21441
P02452-954-unknown	IAGQRG...	954		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21721
P02452-954-unknown	IAGQRG...	954		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24801
P02452-1094-unknown	GDKGET...	1094			unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02452-1201-unknown	LPQPPQ...	1201		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4988
P02452-1207-unknown	EKAHDG...	1207		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4989
P02452-1219-unknown	DDANVV...	1219		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31828
P02452-1219-unknown	DDANVV...	1219		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC648
P02452-1239-unknown	SQQIEN...	1239		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8378

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DGIPGQ	136	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460459
...GNFAPQ	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC308
...AGLPGM	263	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4987
...PGPQGI	953	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21286
...PGPQGI	953	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22094
...PGPQGI	953	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21441
...PGPQGI	953	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21721
...PGPQGI	953	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24801
...FDFSFL	1200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4988
...PQPPQE	1206	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4989
...RYYRAD	1218	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RYYRAD	1218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31828
...RYYRAD	1218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC648
...TLKSLS	1238	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8378

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ATS2_HUMAN	161	FAPQ.\|.QLSY	inferred from experiment	unknown	MEROPS		Merops ATS2_HUMAN -> CO1A1_HUMAN @161
CATK_HUMAN	263	LPGM.\|.MKGH	inferred from experiment	unknown	MEROPS	Risteli J	Sassi ML et al.:Immunochemical characterization... (C01.036)	10719280,
MMP13_HUMAN	953	PQGI.\|.IAGQ	inferred from experiment	unknown	MEROPS		Merops MMP13_HUMAN -> CO1A1_HUMAN @953
MMP2_HUMAN	953	PQGI.\|.IAGQ	inferred from experiment	unknown	MEROPS	Quigley JP	Aimes RT et al.:Matrix metalloproteinase-2 is a... (M10.003)	7890717,
MMP14_HUMAN	953	PQGI.\|.IAGQ	inferred from experiment	unknown	MEROPS	Okada Y	Ohuchi E et al.:Membrane type 1 matrix metallop... (M10.014)	8999957,
MMP1_HUMAN	953	PQGI.\|.IAGQ	inferred from experiment	unknown	MEROPS		Merops MMP1_HUMAN -> CO1A1_HUMAN @953
MMP8_HUMAN	953	PQGI.\|.IAGQ	inferred from experiment	unknown	MEROPS	Krane SM	Krane SM et al.:Is collagenase (matrix metallop... (M10.002)	7641497,
CATK_HUMAN	1200	FSFL.\|.LPQP	inferred from experiment	unknown	MEROPS	Risteli J	Sassi ML et al.:Immunochemical characterization... (C01.036)	10719280,
CATK_HUMAN	1206	PPQE.\|.EKAH	inferred from experiment	unknown	MEROPS	Risteli J	Sassi ML et al.:Immunochemical characterization... (C01.036)	10719280,
TLL1_HUMAN	1218	YRAD.\|.DDAN	inferred from experiment	unknown	MEROPS	Greenspan DS	Scott IC et al.:Mammalian BMP-1/Tolloid-related... (M12.016)	10479448,
BMP1_HUMAN	1218	YRAD.\|.DDAN	inferred from experiment	unknown	MEROPS	Graham MF	Kofford MW et al.:Cleavage of type I procollagen ... (M12.005)	9054407,
BMP1_HUMAN	1218	YRAD.\|.DDAN	inferred from experiment	unknown	MEROPS		Merops BMP1_HUMAN -> CO1A1_HUMAN @1218
CMA1_HUMAN	1238	KSLS.\|.SQQI	inferred from experiment	unknown	MEROPS	Graham MF	Kofford MW et al.:Cleavage of type I procollagen ... (M12.005)	9054407,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)