TopFIND 4.0

O95450: A disintegrin and metalloproteinase with thrombospondin motifs 2

General Information

Protein names
- A disintegrin and metalloproteinase with thrombospondin motifs 2
- ADAM-TS 2
- ADAM-TS2
- ADAMTS-2
- 3.4.24.14
- Procollagen I N-proteinase
- PC I-NP
- Procollagen I/II amino propeptide-processing enzyme
- Procollagen N-endopeptidase
- pNPI
Gene names ADAMTS2
Organism Homo sapiens
Protease Family M12.301
Protease ID M12.301
Chromosome location
UniProt ID O95450

6

N-termini

4

C-termini

12

Cleavages

3

Substrates

Sequence

        10         20         30         40         50         60 
MDPPAGAARR LLCPALLLLL LLLPPPLLPP PPPPANARLA AAADPPGGPL GHGAERILAV 
        70         80         90        100        110        120 
PVRTDAQGRL VSHVVSAATS RAGVRARRAA PVRTPSFPGG NEEEPGSHLF YNVTVFGRDL 
       130        140        150        160        170        180 
HLRLRPNARL VAPGATMEWQ GEKGTTRVEP LLGSCLYVGD VAGLAEASSV ALSNCDGLAG 
       190        200        210        220        230        240 
LIRMEEEEFF IEPLEKGLAA QEAEQGRVHV VYRRPPTSPP LGGPQALDTG ASLDSLDSLS 
       250        260        270        280        290        300 
RALGVLEEHA NSSRRRARRH AADDDYNIEV LLGVDDSVVQ FHGKEHVQKY LLTLMNIVNE 
       310        320        330        340        350        360 
IYHDESLGAH INVVLVRIIL LSYGKSMSLI EIGNPSQSLE NVCRWAYLQQ KPDTGHDEYH 
       370        380        390        400        410        420 
DHAIFLTRQD FGPSGMQGYA PVTGMCHPVR SCTLNHEDGF SSAFVVAHET GHVLGMEHDG 
       430        440        450        460        470        480 
QGNRCGDEVR LGSIMAPLVQ AAFHRFHWSR CSQQELSRYL HSYDCLLDDP FAHDWPALPQ 
       490        500        510        520        530        540 
LPGLHYSMNE QCRFDFGLGY MMCTAFRTFD PCKQLWCSHP DNPYFCKTKK GPPLDGTMCA 
       550        560        570        580        590        600 
PGKHCFKGHC IWLTPDILKR DGSWGAWSPF GSCSRTCGTG VKFRTRQCDN PHPANGGRTC 
       610        620        630        640        650        660 
SGLAYDFQLC SRQDCPDSLA DFREEQCRQW DLYFEHGDAQ HHWLPHEHRD AKERCHLYCE 
       670        680        690        700        710        720 
SRETGEVVSM KRMVHDGTRC SYKDAFSLCV RGDCRKVGCD GVIGSSKQED KCGVCGGDNS 
       730        740        750        760        770        780 
HCKVVKGTFT RSPKKHGYIK MFEIPAGARH LLIQEVDATS HHLAVKNLET GKFILNEEND 
       790        800        810        820        830        840 
VDASSKTFIA MGVEWEYRDE DGRETLQTMG PLHGTITVLV IPVGDTRVSL TYKYMIHEDS 
       850        860        870        880        890        900 
LNVDDNNVLE EDSVVYEWAL KKWSPCSKPC GGGSQFTKYG CRRRLDHKMV HRGFCAALSK 
       910        920        930        940        950        960 
PKAIRRACNP QECSQPVWVT GEWEPCSQTC GRTGMQVRSV RCIQPLHDNT TRSVHAKHCN 
       970        980        990       1000       1010       1020 
DARPESRRAC SRELCPGRWR AGPWSQCSVT CGNGTQERPV LCRTADDSFG ICQEERPETA 
      1030       1040       1050       1060       1070       1080 
RTCRLGPCPR NISDPSKKSY VVQWLSRPDP DSPIRKISSK GHCQGDKSIF CRMEVLSRYC 
      1090       1100       1110       1120       1130       1140 
SIPGYNKLCC KSCNLYNNLT NVEGRIEPPP GKHNDIDVFM PTLPVPTVAM EVRPSPSTPL 
      1150       1160       1170       1180       1190       1200 
EVPLNASSTN ATEDHPETNA VDEPYKIHGL EDEVQPPNLI PRRPSPYEKT RNQRIQELID 
      1210    
EMRKKEMLGK F

Isoforms

- Isoform SpNPI of A disintegrin and metalloproteinase with thrombospondin motifs 2

Sequence View

        10         20         30         40         50         60 
MDPPAGAARR LLCPALLLLL LLLPPPLLPP PPPPANARLA AAADPPGGPL GHGAERILAV 
        70         80         90        100        110        120 
PVRTDAQGRL VSHVVSAATS RAGVRARRAA PVRTPSFPGG NEEEPGSHLF YNVTVFGRDL 
       130        140        150        160        170        180 
HLRLRPNARL VAPGATMEWQ GEKGTTRVEP LLGSCLYVGD VAGLAEASSV ALSNCDGLAG 
       190        200        210        220        230        240 
LIRMEEEEFF IEPLEKGLAA QEAEQGRVHV VYRRPPTSPP LGGPQALDTG ASLDSLDSLS 
       250        260        270        280        290        300 
RALGVLEEHA NSSRRRARRH AADDDYNIEV LLGVDDSVVQ FHGKEHVQKY LLTLMNIVNE 
       310        320        330        340        350        360 
IYHDESLGAH INVVLVRIIL LSYGKSMSLI EIGNPSQSLE NVCRWAYLQQ KPDTGHDEYH 
       370        380        390        400        410        420 
DHAIFLTRQD FGPSGMQGYA PVTGMCHPVR SCTLNHEDGF SSAFVVAHET GHVLGMEHDG 
       430        440        450        460        470        480 
QGNRCGDEVR LGSIMAPLVQ AAFHRFHWSR CSQQELSRYL HSYDCLLDDP FAHDWPALPQ 
       490        500        510        520        530        540 
LPGLHYSMNE QCRFDFGLGY MMCTAFRTFD PCKQLWCSHP DNPYFCKTKK GPPLDGTMCA 
       550        560        570        580        590        600 
PGKHCFKGHC IWLTPDILKR DGSWGAWSPF GSCSRTCGTG VKFRTRQCDN PHPANGGRTC 
       610        620        630        640        650        660 
SGLAYDFQLC SRQDCPDSLA DFREEQCRQW DLYFEHGDAQ HHWLPHEHRD AKERCHLYCE 
       670        680        690        700        710        720 
SRETGEVVSM KRMVHDGTRC SYKDAFSLCV RGDCRKVGCD GVIGSSKQED KCGVCGGDNS 
       730        740        750        760        770        780 
HCKVVKGTFT RSPKKHGYIK MFEIPAGARH LLIQEVDATS HHLAVKNLET GKFILNEEND 
       790        800        810        820        830        840 
VDASSKTFIA MGVEWEYRDE DGRETLQTMG PLHGTITVLV IPVGDTRVSL TYKYMIHEDS 
       850        860        870        880        890        900 
LNVDDNNVLE EDSVVYEWAL KKWSPCSKPC GGGSQFTKYG CRRRLDHKMV HRGFCAALSK 
       910        920        930        940        950        960 
PKAIRRACNP QECSQPVWVT GEWEPCSQTC GRTGMQVRSV RCIQPLHDNT TRSVHAKHCN 
       970        980        990       1000       1010       1020 
DARPESRRAC SRELCPGRWR AGPWSQCSVT CGNGTQERPV LCRTADDSFG ICQEERPETA 
      1030       1040       1050       1060       1070       1080 
RTCRLGPCPR NISDPSKKSY VVQWLSRPDP DSPIRKISSK GHCQGDKSIF CRMEVLSRYC 
      1090       1100       1110       1120       1130       1140 
SIPGYNKLCC KSCNLYNNLT NVEGRIEPPP GKHNDIDVFM PTLPVPTVAM EVRPSPSTPL 
      1150       1160       1170       1180       1190       1200 
EVPLNASSTN ATEDHPETNA VDEPYKIHGL EDEVQPPNLI PRRPSPYEKT RNQRIQELID 
      1210    
EMRKKEMLGK F



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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 12 Cleavages - 3 Substrates

N-termini

C-termini

Cleavages

Substrates