P08123: Collagen alpha-2(I) chain

General Information

Protein names	- Collagen alpha-2(I) chain - Alpha-2 type I collagen
Gene names	COL1A2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P08123

6 N-termini

5 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLSFVDTRTL LLLAVTLCLA TCQSLQEETV RKGPAGDRGP RGERGPPGPP GRDGEDGPTG
        70         80         90        100        110        120
PPGPPGPPGP PGLGGNFAAQ YDGKGVGLGP GPMGLMGPRG PPGAAGAPGP QGFQGPAGEP
       130        140        150        160        170        180
GEPGQTGPAG ARGPAGPPGK AGEDGHPGKP GRPGERGVVG PQGARGFPGT PGLPGFKGIR
       190        200        210        220        230        240
GHNGLDGLKG QPGAPGVKGE PGAPGENGTP GQTGARGLPG ERGRVGAPGP AGARGSDGSV
       250        260        270        280        290        300
GPVGPAGPIG SAGPPGFPGA PGPKGEIGAV GNAGPAGPAG PRGEVGLPGL SGPVGPPGNP
       310        320        330        340        350        360
GANGLTGAKG AAGLPGVAGA PGLPGPRGIP GPVGAAGATG ARGLVGEPGP AGSKGESGNK
       370        380        390        400        410        420
GEPGSAGPQG PPGPSGEEGK RGPNGEAGSA GPPGPPGLRG SPGSRGLPGA DGRAGVMGPP
       430        440        450        460        470        480
GSRGASGPAG VRGPNGDAGR PGEPGLMGPR GLPGSPGNIG PAGKEGPVGL PGIDGRPGPI
       490        500        510        520        530        540
GPAGARGEPG NIGFPGPKGP TGDPGKNGDK GHAGLAGARG APGPDGNNGA QGPPGPQGVQ
       550        560        570        580        590        600
GGKGEQGPPG PPGFQGLPGP SGPAGEVGKP GERGLHGEFG LPGPAGPRGE RGPPGESGAA
       610        620        630        640        650        660
GPTGPIGSRG PSGPPGPDGN KGEPGVVGAV GTAGPSGPSG LPGERGAAGI PGGKGEKGEP
       670        680        690        700        710        720
GLRGEIGNPG RDGARGAPGA VGAPGPAGAT GDRGEAGAAG PAGPAGPRGS PGERGEVGPA
       730        740        750        760        770        780
GPNGFAGPAG AAGQPGAKGE RGAKGPKGEN GVVGPTGPVG AAGPAGPNGP PGPAGSRGDG
       790        800        810        820        830        840
GPPGMTGFPG AAGRTGPPGP SGISGPPGPP GPAGKEGLRG PRGDQGPVGR TGEVGAVGPP
       850        860        870        880        890        900
GFAGEKGPSG EAGTAGPPGT PGPQGLLGAP GILGLPGSRG ERGLPGVAGA VGEPGPLGIA
       910        920        930        940        950        960
GPPGARGPPG AVGSPGVNGA PGEAGRDGNP GNDGPPGRDG QPGHKGERGY PGNIGPVGAA
       970        980        990       1000       1010       1020
GAPGPHGPVG PAGKHGNRGE TGPSGPVGPA GAVGPRGPSG PQGIRGDKGE PGEKGPRGLP
      1030       1040       1050       1060       1070       1080
GLKGHNGLQG LPGIAGHHGD QGAPGSVGPA GPRGPAGPSG PAGKDGRTGH PGTVGPAGIR
      1090       1100       1110       1120       1130       1140
GPQGHQGPAG PPGPPGPPGP PGVSGGGYDF GYDGDFYRAD QPRSAPSLRP KDYEVDATLK
      1150       1160       1170       1180       1190       1200
SLNNQIETLL TPEGSRKNPA RTCRDLRLSH PEWSSGYYWI DPNQGCTMDA IKVYCDFSTG
      1210       1220       1230       1240       1250       1260
ETCIRAQPEN IPAKNWYRSS KDKKHVWLGE TINAGSQFEY NVEGVTSKEM ATQLAFMRLL
      1270       1280       1290       1300       1310       1320
ANYASQNITY HCKNSIAYMD EETGNLKKAV ILQGSNDVEL VAEGNSRFTY TVLVDGCSKK
      1330       1340       1350       1360
TNEWGKTIIE YKTNKPSRLP FLDIAPLDIG GADQEFFVDI GPVCFK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P08123-25-unknown	LQEETV...	25	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P08123-80-unknown	QYDGKG...	80	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P08123-176-unknown	FKGIRG...	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5003
P08123-866-unknown	LLGAPG...	866	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21516
P08123-866-unknown	LLGAPG...	866	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22550
P08123-866-unknown	LLGAPG...	866	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21375
P08123-866-unknown	LLGAPG...	866	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21734
P08123-872-unknown	ILGLPG...	872	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21517
P08123-1120-unknown	DQPRSA...	1120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31835
P08123-1120-unknown	DQPRSA...	1120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC661

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PGLPGF	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5003
...PGPQGL	865	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21516
...PGPQGL	865	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22550
...PGPQGL	865	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21375
...PGPQGL	865	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21734
...LGAPGI	871	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21517
...PGPPGV	1102	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DFYRAD	1119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31835
...DFYRAD	1119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC661
...DFYRAD	1119	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATK_HUMAN	175	LPGF.\|.FKGI	inferred from experiment	unknown	MEROPS	Risteli J	Sassi ML et al.:Immunochemical characterization... (C01.036)	10719280,
MMP14_HUMAN	865	PQGL.\|.LLGA	inferred from experiment	unknown	MEROPS	Okada Y	Ohuchi E et al.:Membrane type 1 matrix metallop... (M10.014)	8999957,
MMP2_HUMAN	865	PQGL.\|.LLGA	inferred from experiment	unknown	MEROPS	Quigley JP	Aimes RT et al.:Matrix metalloproteinase-2 is a... (M10.003)	7890717,
MMP13_HUMAN	865	PQGL.\|.LLGA	inferred from experiment	unknown	MEROPS		Merops MMP13_HUMAN -> CO1A2_HUMAN @865
MMP1_HUMAN	865	PQGL.\|.LLGA	inferred from experiment	unknown	MEROPS	Poole AR	Billinghurst RC et al.:Enhanced cleavage of type II co... (M10.013)	9119997,
MMP14_HUMAN	871	APGI.\|.ILGL	inferred from experiment	unknown	MEROPS	Sato H	Li Y et al.:Cleavage of lumican by membrane... (M10.014)	15466200,
TLL1_HUMAN	1119	YRAD.\|.DQPR	inferred from experiment	unknown	MEROPS	Greenspan DS	Scott IC et al.:Mammalian BMP-1/Tolloid-related... (M12.016)	10479448,
BMP1_HUMAN	1119	YRAD.\|.DQPR	inferred from experiment	unknown	MEROPS	Greenspan DS	Scott IC et al.:Bone morphogenetic protein-1 pr... (M12.005)	10896944,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)