P17936: Insulin-like growth factor-binding protein 3

General Information

Protein names	- Insulin-like growth factor-binding protein 3 - IBP-3 - IGF-binding protein 3 - IGFBP-3
Gene names	IGFBP3
Organism	Homo sapiens
Protease Family
Protease ID	I31.952
Chromosome location
UniProt ID	P17936

31 N-termini

29 C-termini

48 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQRARPTLWA AALTLLVLLR GPPVARAGAS SAGLGPVVRC EPCDARALAQ CAPPPAVCAE
        70         80         90        100        110        120
LVREPGCGCC LTCALSEGQP CGIYTERCGS GLRCQPSPDE ARPLQALLDG RGLCVNASAV
       130        140        150        160        170        180
SRLRAYLLPA PPAPGNASES EEDRSAGSVE SPSVSSTHRV SDPKFHPLHS KIIIIKKGHA
       190        200        210        220        230        240
KDSQRYKVDY ESQSTDTQNF SSESKRETEY GPCRREMEDT LNHLKFLNVL SPRGVHIPNC
       250        260        270        280        290
DKKGFYKKKQ CRPSKGRKRG FCWCVDKYGQ PLPGYTTKGK EDVHCYSMQS K

Isoforms

- Isoform 2 of Insulin-like growth factor-binding protein 3

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

31 N-termini - 29 C-termini - 48 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P17936-1-unknown	MQRARP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77459
P17936-28-unknown	GASSAG...	28	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P17936-28-unknown	GASSAG...	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16446
P17936-28-unknown	GASSAG...	28		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P17936-28-unknown	GASSAG...	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114380
P17936-30-unknown	SSAGLG...	30		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P17936-30-unknown	SSAGLG...	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180497
P17936-37-unknown	VVRCEP...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23880
P17936-37-unknown	VVRCEP...	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt138095
P17936-123-unknown	LRAYLL...	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24722
P17936-123-unknown	LRAYLL...	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27551
P17936-124-unknown	RAYLLP...	124	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22792
P17936-124-unknown	RAYLLP...	124	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21753
P17936-125-unknown	AYLLPA...	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22794
P17936-125-unknown	AYLLPA...	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31768
P17936-125-unknown	AYLLPA...	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27553
P17936-125-unknown	AYLLPA...	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC162
P17936-125-unknown	AYLLPA...	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21755
P17936-126-unknown	YLLPAP...	126	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4577
P17936-127-unknown	LLPAPP...	127	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22796
P17936-127-unknown	LLPAPP...	127	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23882
P17936-127-unknown	LLPAPP...	127	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21757
P17936-137-unknown	ASESEE...	137	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23883
P17936-137-unknown	ASESEE...	137	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197500
P17936-145-unknown	SAGSVE...	145		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P17936-145-unknown	SAGSVE...	145	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180499
P17936-159-unknown	RVSDPK...	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16208
P17936-159-unknown	RVSDPK...	159	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145337
P17936-169-unknown	HSKIII...	169	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22797
P17936-169-unknown	HSKIII...	169	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4829
P17936-169-unknown	HSKIII...	169	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21758
P17936-169-unknown	HSKIII...	169	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145687
P17936-170-unknown	SKIIII...	170	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21760
P17936-170-unknown	SKIIII...	170	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22799
P17936-170-unknown	SKIIII...	170	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27555
P17936-170-unknown	SKIIII...	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145718
P17936-172-unknown	IIIIKK...	172	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24724
P17936-172-unknown	IIIIKK...	172	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145831
P17936-173-unknown	IIIKKG...	173	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5629
P17936-173-unknown	IIIKKG...	173	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145877
P17936-176-unknown	KKGHAK...	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9377
P17936-176-unknown	KKGHAK...	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145977
P17936-186-unknown	YKVDYE...	186	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16448
P17936-186-unknown	YKVDYE...	186	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27557
P17936-186-unknown	YKVDYE...	186	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146305
P17936-187-unknown	KVDYES...	187	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16210
P17936-187-unknown	KVDYES...	187	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4579
P17936-187-unknown	KVDYES...	187	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146357
P17936-188-unknown	VDYESQ...	188	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27559
P17936-188-unknown	VDYESQ...	188	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146402
P17936-191-unknown	ESQSTD...	191	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18809
P17936-191-unknown	ESQSTD...	191	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4581
P17936-191-unknown	ESQSTD...	191	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17407
P17936-191-unknown	ESQSTD...	191	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146480
P17936-195-unknown	TDTQNF...	195	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17409
P17936-195-unknown	TDTQNF...	195	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18811
P17936-195-unknown	TDTQNF...	195	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC673
P17936-195-unknown	TDTQNF...	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146582
P17936-204-unknown	SKRETE...	204	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23884
P17936-204-unknown	SKRETE...	204	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146947
P17936-218-unknown	EDTLNH...	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18813
P17936-218-unknown	EDTLNH...	218	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147522
P17936-219-unknown	DTLNHL...	219	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17411
P17936-219-unknown	DTLNHL...	219	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18815
P17936-219-unknown	DTLNHL...	219	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147532
P17936-226-unknown	FLNVLS...	226	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27561
P17936-226-unknown	FLNVLS...	226	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147816
P17936-227-unknown	LNVLSP...	227	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4831
P17936-227-unknown	LNVLSP...	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147845
P17936-228-unknown	NVLSPR...	228	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4583
P17936-228-unknown	NVLSPR...	228	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147891
P17936-234-unknown	GVHIPN...	234	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31770
P17936-234-unknown	GVHIPN...	234	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16450
P17936-234-unknown	GVHIPN...	234	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148072
P17936-236-unknown	HIPNCD...	236	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9379
P17936-236-unknown	HIPNCD...	236	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148183
P17936-248-unknown	KKQCRP...	248	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27563
P17936-248-unknown	KKQCRP...	248	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148604

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PVARAG	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16446
...PVARAG	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120348
...AGLGPV	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23880
...AGLGPV	36	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121119
...SAVSRL	122	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24722
...SAVSRL	122	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27551
...SAVSRL	122	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126861
...AVSRLR	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22792
...AVSRLR	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21753
...AVSRLR	123	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126871
...VSRLRA	124	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22794
...VSRLRA	124	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31768
...VSRLRA	124	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27553
...VSRLRA	124	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC162
...VSRLRA	124	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21755
...VSRLRA	124	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126927
...SRLRAY	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4577
...SRLRAY	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126995
...RLRAYL	126	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22796
...RLRAYL	126	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23882
...RLRAYL	126	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21757
...RLRAYL	126	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154688
...PAPGNA	136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23883
...VSSTHR	158	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16208
...VSSTHR	158	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128628
...KFHPLH	168	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22797
...KFHPLH	168	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4829
...KFHPLH	168	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21758
...KFHPLH	168	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128985
...FHPLHS	169	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21760
...FHPLHS	169	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22799
...FHPLHS	169	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27555
...FHPLHS	169	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129016
...PLHSKI	171	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24724
...PLHSKI	171	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129128
...LHSKII	172	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5629
...LHSKII	172	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129175
...KIIIIK	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9377
...KIIIIK	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129276
...KDSQRY	185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16448
...KDSQRY	185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27557
...KDSQRY	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129608
...DSQRYK	186	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16210
...DSQRYK	186	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4579
...DSQRYK	186	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129661
...SQRYKV	187	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27559
...SQRYKV	187	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129707
...YKVDYE	190	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18809
...YKVDYE	190	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4581
...YKVDYE	190	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17407
...YKVDYE	190	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129788
...YESQST	194	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17409
...YESQST	194	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18811
...YESQST	194	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC673
...YESQST	194	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129889
...NFSSES	203	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23884
...NFSSES	203	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130278
...CRREME	217	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18813
...CRREME	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130872
...RREMED	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17411
...RREMED	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18815
...RREMED	218	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130883
...LNHLKF	225	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27561
...LNHLKF	225	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131171
...NHLKFL	226	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4831
...NHLKFL	226	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131200
...HLKFLN	227	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4583
...HLKFLN	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131251
...VLSPRG	233	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31770
...VLSPRG	233	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16450
...VLSPRG	233	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131435
...SPRGVH	235	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9379
...SPRGVH	235	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131550
...KGFYKK	247	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27563
...KGFYKK	247	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131978
...SMQSK	291	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SMQSK	291	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73077

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK5_HUMAN	27	ARAG.\|.GASS	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Human tissue kallikrein 5 is a ... (S01.017)	16517595,
MMP3_HUMAN	36	LGPV.\|.VVRC	inferred from experiment	unknown	MEROPS	Cohen P	Gibson TL et al.:Inflammation-related neutrophil... (S01.133)	10512690,
MMP7_HUMAN	122	VSRL.\|.LRAY	inferred from experiment	unknown	MEROPS	Ochiai A	Miyamoto S et al.:Matrix metalloproteinase-7 faci... (M10.008)	14744783,
PLMN_HUMAN	122	VSRL.\|.LRAY	inferred from experiment	unknown	MEROPS	Binoux M	Lalou C et al.:Proteolytic fragments of insuli... (S01.233)	9337997,
MMP2_HUMAN	123	SRLR.\|.RAYL	inferred from experiment	unknown	MEROPS	Nagase H	Fowlkes JL et al.:Matrix metalloproteinases degra... (M10.001)	7523391,
MMP1_HUMAN	123	SRLR.\|.RAYL	inferred from experiment	unknown	MEROPS	Nagase H	Fowlkes JL et al.:Matrix metalloproteinases degra... (M10.001)	7523391,
MMP2_HUMAN	124	RLRA.\|.AYLL	inferred from experiment	unknown	MEROPS	Cohen P	Gibson TL et al.:Inflammation-related neutrophil... (S01.133)	10512690,
THRB_HUMAN	124	RLRA.\|.AYLL	inferred from experiment	unknown	MEROPS	Bar RS	Booth BA et al.:IGFBP-3 proteolysis by plasmin,... (S01.217)	8843739,
PLMN_HUMAN	124	RLRA.\|.AYLL	inferred from experiment	unknown	MEROPS	Cohen P	Gibson TL et al.:Inflammation-related neutrophil... (S01.133)	10512690,
ADA28_HUMAN	124	RLRA.\|.AYLL	inferred from experiment	unknown	MEROPS	Okada Y	Mochizuki S et al.:ADAM28 is activated by MMP-7 (m... (M12.224)	15013428,
MMP1_HUMAN	124	RLRA.\|.AYLL	inferred from experiment	unknown	MEROPS	Cohen P	Gibson TL et al.:Inflammation-related neutrophil... (S01.133)	10512690,
CATD_HUMAN	125	LRAY.\|.YLLP	inferred from experiment	unknown	MEROPS	Braulke T	Claussen M et al.:Proteolysis of insulin-like gro... (A01.009)	9275067,
MMP2_HUMAN	126	RAYL.\|.LLPA	inferred from experiment	unknown	MEROPS	Nagase H	Fowlkes JL et al.:Matrix metalloproteinases degra... (M10.001)	7523391,
MMP3_HUMAN	126	RAYL.\|.LLPA	inferred from experiment	unknown	MEROPS	Nagase H	Fowlkes JL et al.:Matrix metalloproteinases degra... (M10.001)	7523391,
MMP1_HUMAN	126	RAYL.\|.LLPA	inferred from experiment	unknown	MEROPS	Nagase H	Fowlkes JL et al.:Matrix metalloproteinases degra... (M10.001)	7523391,
MMP3_HUMAN	136	PGNA.\|.ASES	inferred from experiment	unknown	MEROPS	Nagase H	Fowlkes JL et al.:Matrix metalloproteinases degra... (M10.001)	7523391,
KLK3_HUMAN	158	STHR.\|.RVSD	inferred from experiment	unknown	MEROPS	Hirano K	Okabe E et al.:The cleavage site specificity o... (S01.162)	10218588,
MMP2_HUMAN	168	HPLH.\|.HSKI	inferred from experiment	unknown	MEROPS	Nagase H	Fowlkes JL et al.:Matrix metalloproteinases degra... (M10.001)	7523391,
CATG_HUMAN	168	HPLH.\|.HSKI	inferred from experiment	unknown	MEROPS	Cohen P	Gibson TL et al.:Inflammation-related neutrophil... (S01.133)	10512690,
MMP1_HUMAN	168	HPLH.\|.HSKI	inferred from experiment	unknown	MEROPS	Nagase H	Fowlkes JL et al.:Matrix metalloproteinases degra... (M10.001)	7523391,
MMP1_HUMAN	169	PLHS.\|.SKII	inferred from experiment	unknown	MEROPS	Cohen P	Gibson TL et al.:Inflammation-related neutrophil... (M10.001)	10512690,
MMP2_HUMAN	169	PLHS.\|.SKII	inferred from experiment	unknown	MEROPS	Cohen P	Gibson TL et al.:Inflammation-related neutrophil... (S01.133)	10512690,
PLMN_HUMAN	169	PLHS.\|.SKII	inferred from experiment	unknown	MEROPS	Binoux M	Lalou C et al.:Proteolytic fragments of insuli... (S01.233)	9337997,
MMP7_HUMAN	171	HSKI.\|.IIII	inferred from experiment	unknown	MEROPS	Ochiai A	Miyamoto S et al.:Matrix metalloproteinase-7 faci... (M10.008)	14744783,
CATL1_HUMAN	172	SKII.\|.IIIK	inferred from experiment	unknown	MEROPS	Braulke T	Zwad O et al.:Decreased intracellular degrada... (C01.032)	11801256,
ELNE_HUMAN	175	IIIK.\|.KKGH	inferred from experiment	unknown	MEROPS	Cohen P	Gibson TL et al.:Inflammation-related neutrophil... (S01.133)	10512690,
KLK5_HUMAN	185	SQRY.\|.YKVD	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Human tissue kallikrein 5 is a ... (S01.017)	16517595,
PLMN_HUMAN	185	SQRY.\|.YKVD	inferred from experiment	unknown	MEROPS	Binoux M	Lalou C et al.:Proteolytic fragments of insuli... (S01.233)	9337997,
KLK3_HUMAN	186	QRYK.\|.KVDY	inferred from experiment	unknown	MEROPS	Hirano K	Okabe E et al.:The cleavage site specificity o... (S01.162)	10218588,
CATD_HUMAN	186	QRYK.\|.KVDY	inferred from experiment	unknown	MEROPS	Braulke T	Claussen M et al.:Proteolysis of insulin-like gro... (A01.009)	9275067,
PLMN_HUMAN	187	RYKV.\|.VDYE	inferred from experiment	unknown	MEROPS	Binoux M	Lalou C et al.:Proteolytic fragments of insuli... (S01.233)	9337997,
MEP1B_HUMAN	190	VDYE.\|.ESQS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATD_HUMAN	190	VDYE.\|.ESQS	inferred from experiment	unknown	MEROPS	Braulke T	Claussen M et al.:Proteolysis of insulin-like gro... (A01.009)	9275067,
MEP1A_HUMAN	190	VDYE.\|.ESQS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	194	SQST.\|.TDTQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	194	SQST.\|.TDTQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
BMP1_HUMAN	194	SQST.\|.TDTQ	inferred from experiment	unknown	MEROPS	Greenspan DS	Kim B et al.:Bone morphogenetic protein-1 pr... (M12.005)	21697095,
MMP3_HUMAN	203	SSES.\|.SKRE	inferred from experiment	unknown	MEROPS	Nagase H	Fowlkes JL et al.:Matrix metalloproteinases degra... (M10.001)	7523391,
MEP1B_HUMAN	217	REME.\|.EDTL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	218	EMED.\|.DTLN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	218	EMED.\|.DTLN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
PLMN_HUMAN	225	HLKF.\|.FLNV	inferred from experiment	unknown	MEROPS	Binoux M	Lalou C et al.:Proteolytic fragments of insuli... (S01.233)	9337997,
CATG_HUMAN	226	LKFL.\|.LNVL	inferred from experiment	unknown	MEROPS	Cohen P	Gibson TL et al.:Inflammation-related neutrophil... (S01.133)	10512690,
CATD_HUMAN	227	KFLN.\|.NVLS	inferred from experiment	unknown	MEROPS	Braulke T	Claussen M et al.:Proteolysis of insulin-like gro... (A01.009)	9275067,
THRB_HUMAN	233	SPRG.\|.GVHI	inferred from experiment	unknown	MEROPS	Bar RS	Booth BA et al.:IGFBP-3 proteolysis by plasmin,... (S01.217)	8843739,
KLK5_HUMAN	233	SPRG.\|.GVHI	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Human tissue kallikrein 5 is a ... (S01.017)	16517595,
ELNE_HUMAN	235	RGVH.\|.HIPN	inferred from experiment	unknown	MEROPS	Cohen P	Gibson TL et al.:Inflammation-related neutrophil... (S01.133)	10512690,
PLMN_HUMAN	247	FYKK.\|.KKQC	inferred from experiment	unknown	MEROPS	Binoux M	Lalou C et al.:Proteolytic fragments of insuli... (S01.233)	9337997,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)