Q9UKQ2: Disintegrin and metalloproteinase domain-containing protein 28

General Information

Protein names	- Disintegrin and metalloproteinase domain-containing protein 28 - ADAM 28 - 3.4.24.- - Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II - eMDC II - Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L - MDC-L
Gene names	ADAM28
Organism	Homo sapiens
Protease Family	M12.224
Protease ID	M12.224
Chromosome location
UniProt ID	Q9UKQ2

4 N-termini

2 C-termini

1 Cleavages

4 Substrates

Sequence

        10         20         30         40         50         60
MLQGLLPVSL LLSVAVSAIK ELPGVKKYEV VYPIRLHPLH KREAKEPEQQ EQFETELKYK
        70         80         90        100        110        120
MTINGKIAVL YLKKNKNLLA PGYTETYYNS TGKEITTSPQ IMDDCYYQGH ILNEKVSDAS
       130        140        150        160        170        180
ISTCRGLRGY FSQGDQRYFI EPLSPIHRDG QEHALFKYNP DEKNYDSTCG MDGVLWAHDL
       190        200        210        220        230        240
QQNIALPATK LVKLKDRKVQ EHEKYIEYYL VLDNGEFKRY NENQDEIRKR VFEMANYVNM
       250        260        270        280        290        300
LYKKLNTHVA LVGMEIWTDK DKIKITPNAS FTLENFSKWR GSVLSRRKRH DIAQLITATE
       310        320        330        340        350        360
LAGTTVGLAF MSTMCSPYSV GVVQDHSDNL LRVAGTMAHE MGHNFGMFHD DYSCKCPSTI
       370        380        390        400        410        420
CVMDKALSFY IPTDFSSCSR LSYDKFFEDK LSNCLFNAPL PTDIISTPIC GNQLVEMGED
       430        440        450        460        470        480
CDCGTSEECT NICCDAKTCK IKATFQCALG ECCEKCQFKK AGMVCRPAKD ECDLPEMCNG
       490        500        510        520        530        540
KSGNCPDDRF QVNGFPCHHG KGHCLMGTCP TLQEQCTELW GPGTEVADKS CYNRNEGGSK
       550        560        570        580        590        600
YGYCRRVDDT LIPCKANDTM CGKLFCQGGS DNLPWKGRIV TFLTCKTFDP EDTSQEIGMV
       610        620        630        640        650        660
ANGTKCGDNK VCINAECVDI EKAYKSTNCS SKCKGHAVCD HELQCQCEEG WIPPDCDDSS
       670        680        690        700        710        720
VVFHFSIVVG VLFPMAVIFV VVAMVIRHQS SREKQKKDQR PLSTTGTRPH KQKRKPQMVK
       730        740        750        760        770
AVQPQEMSQM KPHVYDLPVE GNEPPASFHK DTNALPPTVF KDNPVSTPKD SNPKA

Isoforms

- Isoform 2 of Disintegrin and metalloproteinase domain-containing protein 28

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 4 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9UKQ2-1-unknown	MLQGLL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66310
Q9UKQ2-19-unknown	IKELPG...	19	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9UKQ2-19-unknown	IKELPG...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112251
Q9UKQ2-197-unknown	RKVQEH...	197	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24784
Q9UKQ2-197-unknown	RKVQEH...	197	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146505
Q9UKQ2-199-unknown	VQEHEK...	199	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9UKQ2-199-unknown	VQEHEK...	199	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116013
Q9UKQ2-199-unknown	VQEHEK...	199	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VKLKDR	196	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24784
...VKLKDR	196	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129813
...SNPKA	775	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP7_HUMAN	196	LKDR.\|.RKVQ	inferred from experiment	unknown	MEROPS	Okada Y	Mochizuki S et al.:ADAM28 is activated by MMP-7 (m... (M12.224)	15013428,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
IBP3_HUMAN	124	RLRA.\|.AYLL	inferred from experiment	unknown	MEROPS	Okada Y	Mochizuki S et al.:ADAM28 is activated by MMP-7 (m... (M12.224)	15013428,
IBP3-Isoform2_HUMAN	124	RLRA.\|.AYLL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC162
CCN2_HUMAN	181	LAAY.\|.YRLE	inferred from experiment	unknown	MEROPS	Okada Y	Mochizuki S et al.:ADAM28 is activated by MMP-7 (m... (M12.224)	15013428,
CCN2_HUMAN	191	GPDP.\|.PTMI	inferred from experiment	unknown	MEROPS	Okada Y	Mochizuki S et al.:ADAM28 is activated by MMP-7 (m... (M12.224)	15013428,