P01241: Somatotropin

General Information

Protein names	- Somatotropin - Growth hormone - GH - GH-N - Growth hormone 1 - Pituitary growth hormone
Gene names	GH1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P01241

8 N-termini

7 C-termini

9 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Somatotropin - Isoform 3 of Somatotropin - Isoform 4 of Somatotropin - Isoform 5 of Somatotropin

Sequence View

        10         20         30         40         50         60
MATGSRTSLL LAFGLLCLPW LQEGSAFPTI PLSRLFDNAM LRAHRLHQLA FDTYQEFEEA
        70         80         90        100        110        120
YIPKEQKYSF LQNPQTSLCF SESIPTPSNR EETQQKSNLE LLRISLLLIQ SWLEPVQFLR
       130        140        150        160        170        180
SVFANSLVYG ASDSNVYDLL KDLEEGIQTL MGRLEDGSPR TGQIFKQTYS KFDTNSHNDD
       190        200        210
ALLKNYGLLY CFRKDMDKVE TFLRIVQCRS VEGSCGF         10         20         30         40         50         60
MATGSRTSLL LAFGLLCLPW LQEGSAFPTI PLSRLFDNAM LRAHRLHQLA FDTYQEFEEA
        70         80         90        100        110        120
YIPKEQKYSF LQNPQTSLCF SESIPTPSNR EETQQKSNLE LLRISLLLIQ SWLEPVQFLR
       130        140        150        160        170        180
SVFANSLVYG ASDSNVYDLL KDLEEGIQTL MGRLEDGSPR TGQIFKQTYS KFDTNSHNDD
       190        200        210
ALLKNYGLLY CFRKDMDKVE TFLRIVQCRS VEGSCGF         10         20         30         40         50         60
MATGSRTSLL LAFGLLCLPW LQEGSAFPTI PLSRLFDNAM LRAHRLHQLA FDTYQEFEEA
        70         80         90        100        110        120
YIPKEQKYSF LQNPQTSLCF SESIPTPSNR EETQQKSNLE LLRISLLLIQ SWLEPVQFLR
       130        140        150        160        170        180
SVFANSLVYG ASDSNVYDLL KDLEEGIQTL MGRLEDGSPR TGQIFKQTYS KFDTNSHNDD
       190        200        210
ALLKNYGLLY CFRKDMDKVE TFLRIVQCRS VEGSCGF         10         20         30         40         50         60
MATGSRTSLL LAFGLLCLPW LQEGSAFPTI PLSRLFDNAM LRAHRLHQLA FDTYQEFEEA
        70         80         90        100        110        120
YIPKEQKYSF LQNPQTSLCF SESIPTPSNR EETQQKSNLE LLRISLLLIQ SWLEPVQFLR
       130        140        150        160        170        180
SVFANSLVYG ASDSNVYDLL KDLEEGIQTL MGRLEDGSPR TGQIFKQTYS KFDTNSHNDD
       190        200        210
ALLKNYGLLY CFRKDMDKVE TFLRIVQCRS VEGSCGF

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 7 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P01241-1-unknown	MATGSR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt90241
P01241-1-unknown	MATGSR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt90242
P01241-1-unknown	MATGSR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt90243
P01241-1-unknown	MATGSR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt90244
P01241-27-unknown	FPTIPL...	27	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01241-27-unknown	FPTIPL...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114186
P01241-27-unknown	FPTIPL...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114187
P01241-27-unknown	FPTIPL...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114188
P01241-27-unknown	FPTIPL...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114189
P01241-35-unknown	LFDNAM...	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16413
P01241-35-unknown	LFDNAM...	35	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137935
P01241-35-unknown	LFDNAM...	35	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137937
P01241-35-unknown	LFDNAM...	35	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137939
P01241-35-unknown	LFDNAM...	35	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137941
P01241-91-unknown	EETQQK...	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15912
P01241-91-unknown	EETQQK...	91	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141025
P01241-91-unknown	EETQQK...	91	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141867
P01241-121-unknown	SVFANS...	121	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16418
P01241-121-unknown	SVFANS...	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141336
P01241-121-unknown	SVFANS...	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142672
P01241-161-unknown	TGQIFK...	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16643
P01241-161-unknown	TGQIFK...	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16252
P01241-161-unknown	TGQIFK...	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16511
P01241-161-unknown	TGQIFK...	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15861
P01241-161-unknown	TGQIFK...	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143497
P01241-161-unknown	TGQIFK...	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143584
P01241-161-unknown	TGQIFK...	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144548
P01241-170-unknown	SKFDTN...	170	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15916
P01241-170-unknown	SKFDTN...	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143885
P01241-170-unknown	SKFDTN...	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143959
P01241-170-unknown	SKFDTN...	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144939
P01241-170-unknown	SKFDTN...	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197407
P01241-179-unknown	DDALLK...	179	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC643
P01241-179-unknown	DDALLK...	179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144008
P01241-179-unknown	DDALLK...	179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144258
P01241-179-unknown	DDALLK...	179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144353
P01241-179-unknown	DDALLK...	179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145305

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IPLSRL	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16413
...IPLSRL	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120944
...IPLSRL	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120946
...IPLSRL	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120948
...IPLSRL	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120950
...TPSNRE	90	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15912
...TPSNRE	90	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125045
...TPSNRE	90	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125046
...VQFLRS	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16418
...VQFLRS	120	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124503
...VQFLRS	120	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125872
...DGSPRT	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16643
...DGSPRT	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16252
...DGSPRT	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16511
...DGSPRT	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15861
...DGSPRT	160	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126731
...DGSPRT	160	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127815
...FKQTYS	169	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15916
...FKQTYS	169	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127129
...FKQTYS	169	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127202
...FKQTYS	169	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128215
...TNSHND	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC643
...TNSHND	178	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127513
...TNSHND	178	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127615
...TNSHND	178	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128596
...GSCGF	217	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GSCGF	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85861
...GSCGF	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85862
...GSCGF	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85860
...GSCGF	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85859

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK5_HUMAN	34	LSRL.\|.LFDN	inferred from experiment	unknown	MEROPS		Merops KLK5_HUMAN -> SOMA_HUMAN @34
KLK5_HUMAN	34	LSRL.\|.LFDN	inferred from experiment	unknown	MEROPS	Diamandis EP	Komatsu N et al.:Proteolytic processing of human... (S01.306)	17140555,
KLK14_HUMAN	90	SNRE.\|.EETQ	inferred from experiment	unknown	MEROPS		Merops KLK14_HUMAN -> SOMA_HUMAN @90
KLK14_HUMAN	90	SNRE.\|.EETQ	inferred from experiment	unknown	MEROPS	Diamandis EP	Komatsu N et al.:Proteolytic processing of human... (S01.306)	17140555,
KLK5_HUMAN	120	FLRS.\|.SVFA	inferred from experiment	unknown	MEROPS		Merops KLK5_HUMAN -> SOMA_HUMAN @120
KLK5_HUMAN	120	FLRS.\|.SVFA	inferred from experiment	unknown	MEROPS	Diamandis EP	Komatsu N et al.:Proteolytic processing of human... (S01.306)	17140555,
KLK8_HUMAN	160	SPRT.\|.TGQI	inferred from experiment	unknown	MEROPS		Merops KLK8_HUMAN -> SOMA_HUMAN @160
KLK8_HUMAN	160	SPRT.\|.TGQI	inferred from experiment	unknown	MEROPS	Diamandis EP	Komatsu N et al.:Proteolytic processing of human... (S01.306)	17140555,
KLK4_HUMAN	160	SPRT.\|.TGQI	inferred from experiment	unknown	MEROPS		Merops KLK4_HUMAN -> SOMA_HUMAN @160
KLK4_HUMAN	160	SPRT.\|.TGQI	inferred from experiment	unknown	MEROPS	Diamandis EP	Komatsu N et al.:Proteolytic processing of human... (S01.306)	17140555,
KLK6_HUMAN	160	SPRT.\|.TGQI	inferred from experiment	unknown	MEROPS		Merops KLK6_HUMAN -> SOMA_HUMAN @160
KLK6_HUMAN	160	SPRT.\|.TGQI	inferred from experiment	unknown	MEROPS	Diamandis EP	Komatsu N et al.:Proteolytic processing of human... (S01.306)	17140555,
KLK13_HUMAN	160	SPRT.\|.TGQI	inferred from experiment	unknown	MEROPS		Merops KLK13_HUMAN -> SOMA_HUMAN @160
KLK13_HUMAN	160	SPRT.\|.TGQI	inferred from experiment	unknown	MEROPS	Diamandis EP	Komatsu N et al.:Proteolytic processing of human... (S01.306)	17140555,
KLK14_HUMAN	169	QTYS.\|.SKFD	inferred from experiment	unknown	MEROPS		Merops KLK14_HUMAN -> SOMA_HUMAN @169
KLK14_HUMAN	169	QTYS.\|.SKFD	inferred from experiment	unknown	MEROPS	Diamandis EP	Komatsu N et al.:Proteolytic processing of human... (S01.306)	17140555,
BMP1_HUMAN	178	SHND.\|.DDAL	inferred from experiment	unknown	MEROPS	Greenspan DS	Ge G et al.:Bone morphogenetic protein 1 pr... (M12.005)	17548836,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)