Q9UKR3: Kallikrein-13
Protein names | - Kallikrein-13 - 3.4.21.- - Kallikrein-like protein 4 - KLK-L4 |
---|---|
Gene names | KLK13 |
Organism | Homo sapiens |
Protease Family | S01.306 |
Protease ID | S01.306 |
Chromosome location | |
UniProt ID | Q9UKR3 |
3
N-termini
3
C-termini
6
Cleavages
52
Substrates
Sequence
10 20 30 40 50 60
MWPLALVIAS LTLALSGGVS QESSKVLNTN GTSGFLPGGY TCFPHSQPWQ AALLVQGRLL
70 80 90 100 110 120
CGGVLVHPKW VLTAAHCLKE GLKVYLGKHA LGRVEAGEQV REVVHSIPHP EYRRSPTHLN
130 140 150 160 170 180
HDHDIMLLEL QSPVQLTGYI QTLPLSHNNR LTPGTTCRVS GWGTTTSPQV NYPKTLQCAN
190 200 210 220 230 240
IQLRSDEECR QVYPGKITDN MLCAGTKEGG KDSCEGDSGG PLVCNRTLYG IVSWGDFPCG
250 260 270
QPDRPGVYTR VSRYVLWIRE TIRKYETQQQ KWLKGPQ
Isoforms
- Isoform 2 of Kallikrein-13Sequence View
10 20 30 40 50 60
MWPLALVIAS LTLALSGGVS QESSKVLNTN GTSGFLPGGY TCFPHSQPWQ AALLVQGRLL
70 80 90 100 110 120
CGGVLVHPKW VLTAAHCLKE GLKVYLGKHA LGRVEAGEQV REVVHSIPHP EYRRSPTHLN
130 140 150 160 170 180
HDHDIMLLEL QSPVQLTGYI QTLPLSHNNR LTPGTTCRVS GWGTTTSPQV NYPKTLQCAN
190 200 210 220 230 240
IQLRSDEECR QVYPGKITDN MLCAGTKEGG KDSCEGDSGG PLVCNRTLYG IVSWGDFPCG
250 260 270
QPDRPGVYTR VSRYVLWIRE TIRKYETQQQ KWLKGPQ
Protein Neighborhood
Domains & Features
3 N-termini - 3 C-termini - 6 Cleavages - 52 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q9UKR3-17-unknown | GGVSQE... | 17 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q9UKR3-26-unknown | VLNTNG... | 26 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16398 | |||
Q9UKR3-26-unknown | VLNTNG... | 26 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16493 | |||
Q9UKR3-26-unknown | VLNTNG... | 26 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16023 | |||
Q9UKR3-26-unknown | VLNTNG... | 26 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15851 | |||
Q9UKR3-26-unknown | VLNTNG... | 26 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16113 | |||
Q9UKR3-115-unknown | SPTHLN... | 115 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15903 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...QESSKV | 25 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16398 | |||
...QESSKV | 25 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16493 | |||
...QESSKV | 25 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16023 | |||
...QESSKV | 25 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15851 | |||
...QESSKV | 25 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16113 | |||
...PEYRRS | 114 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15903 | |||
...LKGPQ | 277 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
KLK4_HUMAN | 25 | SSKV.|.VLNT | inferred from experiment | unknown | MEROPS | Blaber M | Yoon H et al.:Activation profiles and regulat... (S01.257) | 17823117, |
KLK5_HUMAN | 25 | SSKV.|.VLNT | inferred from experiment | unknown | MEROPS | Blaber M | Yoon H et al.:Activation profiles and regulat... (S01.257) | 17823117, |
KLK14_HUMAN | 25 | SSKV.|.VLNT | inferred from experiment | unknown | MEROPS | Blaber M | Yoon H et al.:Activation profiles and regulat... (S01.257) | 17823117, |
KLK12_HUMAN | 25 | SSKV.|.VLNT | inferred from experiment | unknown | MEROPS | Blaber M | Yoon H et al.:Activation profiles and regulat... (S01.257) | 17823117, |
KLK2_HUMAN | 25 | SSKV.|.VLNT | inferred from experiment | unknown | MEROPS | Blaber M | Yoon H et al.:Activation profiles and regulat... (S01.257) | 17823117, |
KLK13_HUMAN | 114 | YRRS.|.SPTH | inferred from experiment | unknown | MEROPS | Diamandis EP | Sotiropoulou G et al.:Emerging interest in the kallik... (S01.306) | 12725528, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
KLK6_HUMAN | 21 | QNKL.|.LVHG | inferred from experiment | unknown | MEROPS | Blaber M | Yoon H et al.:Activation profiles and regulat... (S01.257) | 17823117, |
KLK12_HUMAN | 21 | TPKI.|.IFNG | inferred from experiment | unknown | MEROPS | Blaber M | Yoon H et al.:Activation profiles and regulat... (S01.257) | 17823117, |
KLK12-Isoform3_HUMAN | 21 | TPKI.|.IFNG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15900 | ||
KLK11-Isoform4_HUMAN | 21 | ETRI.|.IIKG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15895 | ||
KLK11-Isoform1_HUMAN | 21 | ETRI.|.IIKG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15895 | ||
KLK12-Isoform2_HUMAN | 21 | TPKI.|.IFNG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15900 | ||
KLK9_HUMAN | 22 | DTRA.|.AIGA | inferred from experiment | unknown | MEROPS | Blaber M | Yoon H et al.:Activation profiles and regulat... (S01.257) | 17823117, |
KLK1_HUMAN | 24 | QSRI.|.IVGG | inferred from experiment | unknown | MEROPS | Blaber M | Yoon H et al.:Activation profiles and regulat... (S01.257) | 17823117, |
KLK3_HUMAN | 24 | LSRI.|.IVGG | inferred from experiment | unknown | MEROPS | Blaber M | Yoon H et al.:Activation profiles and regulat... (S01.257) | 17823117, |
KLK2_HUMAN | 24 | QSRI.|.IVGG | inferred from experiment | unknown | MEROPS | Blaber M | Yoon H et al.:Activation profiles and regulat... (S01.257) | 17823117, |
KLK3-Isoform5_HUMAN | 24 | LSRI.|.IVGG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15883 | ||
KLK3-Isoform4_HUMAN | 24 | LSRI.|.IVGG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15883 | ||
KLK3-Isoform3_HUMAN | 24 | LSRI.|.IVGG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15883 | ||
KLK2-Isoform3_HUMAN | 24 | QSRI.|.IVGG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15888 | ||
KLK2-Isoform2_HUMAN | 24 | QSRI.|.IVGG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15888 | ||
KLK3-Isoform2_HUMAN | 24 | LSRI.|.IVGG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15883 | ||
KLK11_HUMAN | 53 | ETRI.|.IIKG | inferred from experiment | unknown | MEROPS | Blaber M | Yoon H et al.:Activation profiles and regulat... (S01.257) | 17823117, |
KLK11-Isoform3_HUMAN | 53 | ETRI.|.IIKG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15895 | ||
KLK5_HUMAN | 66 | SSRI.|.IING | inferred from experiment | unknown | MEROPS | Blaber M | Yoon H et al.:Activation profiles and regulat... (S01.257) | 17823117, |
KLK13_HUMAN | 114 | YRRS.|.SPTH | inferred from experiment | unknown | MEROPS | Diamandis EP | Sotiropoulou G et al.:Emerging interest in the kallik... (S01.306) | 12725528, |
SOMA-Isoform5_HUMAN | 120 | SPRT.|.TGQI | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15861 | ||
SOMA-Isoform3_HUMAN | 122 | SPRT.|.TGQI | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15861 | ||
SOMA-Isoform2_HUMAN | 145 | SPRT.|.TGQI | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15861 | ||
SOMA_HUMAN | 160 | SPRT.|.TGQI | inferred from experiment | unknown | MEROPS | Merops KLK13_HUMAN -> SOMA_HUMAN @160 | ||
SOMA_HUMAN | 160 | SPRT.|.TGQI | inferred from experiment | unknown | MEROPS | Diamandis EP | Komatsu N et al.:Proteolytic processing of human... (S01.306) | 17140555, |
NETR_HUMAN | 173 | RLRG.|.GGKN | inferred from experiment | unknown | MEROPS | Diamandis EP | Borgono CA et al.:Defining the extended substrate... (S01.306) | 17976015, |
UROK-Isoform2_HUMAN | 226 | RSRL.|.LNSN | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15859 | ||
UROK_HUMAN | 243 | RSRL.|.LNSN | inferred from experiment | unknown | MEROPS | Diamandis EP | Borgono CA et al.:Defining the extended substrate... (S01.306) | 17976015, |
LAMA5_HUMAN | 262 | RLRF.|.FLRT | inferred from experiment | unknown | MEROPS | Diamandis EP | Borgono CA et al.:Defining the extended substrate... (S01.306) | 17976015, |
CO7A1_HUMAN | 295 | RLRG.|.GLRP | inferred from experiment | unknown | MEROPS | Diamandis EP | Borgono CA et al.:Defining the extended substrate... (S01.306) | 17976015, |
CO7A1-Isoform2_HUMAN | 295 | RLRG.|.GLRP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15892 | ||
THYG_HUMAN | 296 | RFRC.|.CPTK | inferred from experiment | unknown | MEROPS | Diamandis EP | Borgono CA et al.:Defining the extended substrate... (S01.306) | 17976015, |
THYG-Isoform2_HUMAN | 296 | RFRC.|.CPTK | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15865 | ||
CAD16-Isoform3_HUMAN | 416 | RLRL.|.LCKN | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15855 | ||
CAD16-Isoform4_HUMAN | 513 | RLRL.|.LCKN | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15855 | ||
CAD16-Isoform2_HUMAN | 513 | RLRL.|.LCKN | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15855 | ||
CAD16_HUMAN | 513 | RLRL.|.LCKN | inferred from experiment | unknown | MEROPS | Diamandis EP | Borgono CA et al.:Defining the extended substrate... (S01.306) | 17976015, |
ATS3_HUMAN | 574 | RFRT.|.TRQC | inferred from experiment | unknown | MEROPS | Diamandis EP | Borgono CA et al.:Defining the extended substrate... (S01.306) | 17976015, |
FINC-Isoform12_HUMAN | 1607 | RARI.|.ITGY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15867 | ||
FINC-Isoform9_HUMAN | 1839 | RARI.|.ITGY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15867 | ||
FINC-Isoform8_HUMAN | 1839 | RARI.|.ITGY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15867 | ||
FINC-Isoform14_HUMAN | 1839 | RARI.|.ITGY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15867 | ||
FINC-Isoform10_HUMAN | 1839 | RARI.|.ITGY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15867 | ||
FINC_HUMAN | 1929 | RARI.|.ITGY | inferred from experiment | unknown | MEROPS | Diamandis EP | Borgono CA et al.:Defining the extended substrate... (S01.306) | 17976015, |
FINC-Isoform6_HUMAN | 1929 | RARI.|.ITGY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15867 | ||
FINC-Isoform5_HUMAN | 1929 | RARI.|.ITGY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15867 | ||
FINC-Isoform4_HUMAN | 1929 | RARI.|.ITGY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15867 | ||
FINC-Isoform3_HUMAN | 1929 | RARI.|.ITGY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15867 | ||
FINC-Isoform17_HUMAN | 1929 | RARI.|.ITGY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15867 | ||
FINC-Isoform11_HUMAN | 1929 | RARI.|.ITGY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15867 | ||
FINC-Isoform13_HUMAN | 1930 | RARI.|.ITGY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15867 | ||
FINC-Isoform7_HUMAN | 2020 | RARI.|.ITGY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15867 | ||
FINC-Isoform15_HUMAN | 2020 | RARI.|.ITGY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15867 |