P06870: Kallikrein-1

General Information

Protein names	- Kallikrein-1 - 3.4.21.35 - Kidney/pancreas/salivary gland kallikrein - Tissue kallikrein
Gene names	KLK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P06870

2 N-termini

2 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MWFLVLCLAL SLGGTGAAPP IQSRIVGGWE CEQHSQPWQA ALYHFSTFQC GGILVHRQWV
        70         80         90        100        110        120
LTAAHCISDN YQLWLGRHNL FDDENTAQFV HVSESFPHPG FNMSLLENHT RQADEDYSHD
       130        140        150        160        170        180
LMLLRLTEPA DTITDAVKVV ELPTEEPEVG STCLASGWGS IEPENFSFPD DLQCVDLKIL
       190        200        210        220        230        240
PNDECKKAHV QKVTDFMLCV GHLEGGKDTC VGDSGGPLMC DGVLQGVTSW GYVPCGTPNK
       250        260
PSVAVRVLSY VKWIEDTIAE NS

Isoforms

- Isoform 2 of Kallikrein-1

Sequence View

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Evidence Codes:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P06870-19-unknown	PPIQSR...	19	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P06870-25-unknown	IVGGWE...	25	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P06870-25-unknown	IVGGWE...	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15882
P06870-25-unknown	IVGGWE...	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16664
P06870-25-unknown	IVGGWE...	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16429
P06870-25-unknown	IVGGWE...	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16199
P06870-25-unknown	IVGGWE...	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15971
P06870-25-unknown	IVGGWE...	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16495
P06870-25-unknown	IVGGWE...	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16286
P06870-25-unknown	IVGGWE...	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15802
P06870-25-unknown	IVGGWE...	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16078
P06870-25-unknown	IVGGWE...	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15827
P06870-25-unknown	IVGGWE...	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16608

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PIQSRI	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15882
...PIQSRI	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16664
...PIQSRI	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16429
...PIQSRI	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16199
...PIQSRI	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15971
...PIQSRI	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16495
...PIQSRI	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16286
...PIQSRI	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15802
...PIQSRI	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16078
...PIQSRI	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15827
...PIQSRI	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16608
...IAENS	262	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...IAENS	262	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74762

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK13_HUMAN	24	QSRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK8_HUMAN	24	QSRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK5_HUMAN	24	QSRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Human tissue kallikrein 5 is a ... (S01.017)	16517595,
KLK3_HUMAN	24	QSRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK14_HUMAN	24	QSRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Diamandis EP	Emami N et al.:Human kallikrein-related peptid... (S01.029)	18056261,
KLK7_HUMAN	24	QSRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK4_HUMAN	24	QSRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK11_HUMAN	24	QSRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK2_HUMAN	24	QSRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK12_HUMAN	24	QSRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK6_HUMAN	24	QSRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)