P49862: Kallikrein-7
| Protein names | - Kallikrein-7 - hK7 - 3.4.21.117 - Serine protease 6 - Stratum corneum chymotryptic enzyme - hSCCE |
|---|---|
| Gene names | KLK7 |
| Organism | Homo sapiens |
| Protease Family | S01.300 |
| Protease ID | S01.300 |
| Chromosome location | |
| UniProt ID | P49862 |
2
N-termini
2
C-termini
4
Cleavages
14
Substrates
Sequence
10 20 30 40 50 60
MARSLLLPLQ ILLLSLALET AGEEAQGDKI IDGAPCARGS HPWQVALLSG NQLHCGGVLV
70 80 90 100 110 120
NERWVLTAAH CKMNEYTVHL GSDTLGDRRA QRIKASKSFR HPGYSTQTHV NDLMLVKLNS
130 140 150 160 170 180
QARLSSMVKK VRLPSRCEPP GTTCTVSGWG TTTSPDVTFP SDLMCVDVKL ISPQDCTKVY
190 200 210 220 230 240
KDLLENSMLC AGIPDSKKNA CNGDSGGPLV CRGTLQGLVS WGTFPCGQPN DPGVYTQVCK
250
FTKWINDTMK KHR
Isoforms
- Isoform 2 of Kallikrein-7Sequence View
10 20 30 40 50 60
MARSLLLPLQ ILLLSLALET AGEEAQGDKI IDGAPCARGS HPWQVALLSG NQLHCGGVLV
70 80 90 100 110 120
NERWVLTAAH CKMNEYTVHL GSDTLGDRRA QRIKASKSFR HPGYSTQTHV NDLMLVKLNS
130 140 150 160 170 180
QARLSSMVKK VRLPSRCEPP GTTCTVSGWG TTTSPDVTFP SDLMCVDVKL ISPQDCTKVY
190 200 210 220 230 240
KDLLENSMLC AGIPDSKKNA CNGDSGGPLV CRGTLQGLVS WGTFPCGQPN DPGVYTQVCK
250
FTKWINDTMK KHR
Protein Neighborhood
Domains & Features
2 N-termini - 2 C-termini - 4 Cleavages - 14 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P49862-30-unknown | IIDGAP... | 30 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P49862-30-unknown | IIDGAP... | 30 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16464 | |||
| P49862-30-unknown | IIDGAP... | 30 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15993 | |||
| P49862-30-unknown | IIDGAP... | 30 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15836 | |||
| P49862-30-unknown | IIDGAP... | 30 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16622 | |||
| P49862-73-unknown | MNEYTV... | 73 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt79154 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...AQGDKI | 29 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16464 | |||
| ...AQGDKI | 29 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15993 | |||
| ...AQGDKI | 29 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15836 | |||
| ...AQGDKI | 29 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16622 | |||
| ...MKKHR | 253 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...MKKHR | 253 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt74772 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| KLK5_HUMAN | 29 | GDKI.|.IIDG | inferred from experiment | unknown | MEROPS | Egelrud T | Brattsand M et al.:A proteolytic cascade of kallik... (S01.017) | 15654974, |
| KLK14_HUMAN | 29 | GDKI.|.IIDG | inferred from experiment | unknown | MEROPS | Diamandis EP | Emami N et al.:Human kallikrein-related peptid... (S01.029) | 18056261, |
| KLK12_HUMAN | 29 | GDKI.|.IIDG | inferred from experiment | unknown | MEROPS | Blaber M | Yoon H et al.:Activation profiles and regulat... (S01.257) | 17823117, |
| KLK6_HUMAN | 29 | GDKI.|.IIDG | inferred from experiment | unknown | MEROPS | Blaber M | Yoon H et al.:Activation profiles and regulat... (S01.257) | 17823117, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| KLK9_HUMAN | 22 | DTRA.|.AIGA | inferred from experiment | unknown | MEROPS | Blaber M | Yoon H et al.:Activation profiles and regulat... (S01.257) | 17823117, |
| KLK1_HUMAN | 24 | QSRI.|.IVGG | inferred from experiment | unknown | MEROPS | Blaber M | Yoon H et al.:Activation profiles and regulat... (S01.257) | 17823117, |
| KLK3_HUMAN | 24 | LSRI.|.IVGG | inferred from experiment | unknown | MEROPS | Blaber M | Yoon H et al.:Activation profiles and regulat... (S01.257) | 17823117, |
| KLK3-Isoform5_HUMAN | 24 | LSRI.|.IVGG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16496 | ||
| KLK3-Isoform4_HUMAN | 24 | LSRI.|.IVGG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16496 | ||
| KLK3-Isoform3_HUMAN | 24 | LSRI.|.IVGG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16496 | ||
| KLK3-Isoform2_HUMAN | 24 | LSRI.|.IVGG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16496 | ||
| KLK2_HUMAN | 24 | QSRI.|.IVGG | inferred from experiment | unknown | MEROPS | Blaber M | Yoon H et al.:Activation profiles and regulat... (S01.257) | 17823117, |
| KLK2-Isoform3_HUMAN | 24 | QSRI.|.IVGG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16501 | ||
| KLK2-Isoform2_HUMAN | 24 | QSRI.|.IVGG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16501 | ||
| CAMP_HUMAN | 138 | GDFF.|.FRKS | inferred from experiment | unknown | MEROPS | Gallo RL | Yamasaki K et al.:Kallikrein-mediated proteolysis... (S01.017) | 17012259, |
| CAMP_HUMAN | 139 | DFFR.|.RKSK | inferred from experiment | unknown | MEROPS | Gallo RL | Yamasaki K et al.:Kallikrein-mediated proteolysis... (S01.017) | 17012259, |
| CAMP_HUMAN | 150 | KEFK.|.KRIV | inferred from experiment | unknown | MEROPS | Gallo RL | Yamasaki K et al.:Kallikrein-mediated proteolysis... (S01.017) | 17012259, |
| CAMP_HUMAN | 160 | KDFL.|.LRNL | inferred from experiment | unknown | MEROPS | Gallo RL | Yamasaki K et al.:Kallikrein-mediated proteolysis... (S01.017) | 17012259, |