Q9UKR0: Kallikrein-12

General Information

Protein names	- Kallikrein-12 - 3.4.21.- - Kallikrein-like protein 5 - KLK-L5
Gene names	KLK12
Organism	Homo sapiens
Protease Family	S01.020
Protease ID	S01.020
Chromosome location
UniProt ID	Q9UKR0

3 N-termini

2 C-termini

8 Cleavages

34 Substrates

Sequence

Isoforms

- Isoform 2 of Kallikrein-12 - Isoform 3 of Kallikrein-12

Sequence View

        10         20         30         40         50         60
MGLSIFLLLC VLGLSQAATP KIFNGTECGR NSQPWQVGLF EGTSLRCGGV LIDHRWVLTA
        70         80         90        100        110        120
AHCSGSRYWV RLGEHSLSQL DWTEQIRHSG FSVTHPGYLG ASTSHEHDLR LLRLRLPVRV
       130        140        150        160        170        180
TSSVQPLPLP NDCATAGTEC HVSGWGITNH PRNPFPDLLQ CLNLSIVSHA TCHGVYPGRI
       190        200        210        220        230        240
TSNMVCAGGV PGQDACQGDS GGPLVCGGVL QGLVSWGSVG PCGQDGIPGV YTYICKYVDW

IRMIMRNN         10         20         30         40         50         60
MGLSIFLLLC VLGLSQAATP KIFNGTECGR NSQPWQVGLF EGTSLRCGGV LIDHRWVLTA
        70         80         90        100        110        120
AHCSGSRYWV RLGEHSLSQL DWTEQIRHSG FSVTHPGYLG ASTSHEHDLR LLRLRLPVRV
       130        140        150        160        170        180
TSSVQPLPLP NDCATAGTEC HVSGWGITNH PRNPFPDLLQ CLNLSIVSHA TCHGVYPGRI
       190        200        210        220        230        240
TSNMVCAGGV PGQDACQGDS GGPLVCGGVL QGLVSWGSVG PCGQDGIPGV YTYICKYVDW

IRMIMRNN

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9UKR0-1-unknown	MGLSIF...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79138
Q9UKR0-1-unknown	MGLSIF...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79139
Q9UKR0-18-unknown	ATPKIF...	18	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9UKR0-18-unknown	ATPKIF...	18	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111930
Q9UKR0-18-unknown	ATPKIF...	18	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111931
Q9UKR0-22-unknown	IFNGTE...	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16395
Q9UKR0-22-unknown	IFNGTE...	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15900
Q9UKR0-22-unknown	IFNGTE...	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16679
Q9UKR0-22-unknown	IFNGTE...	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16020
Q9UKR0-22-unknown	IFNGTE...	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15814
Q9UKR0-22-unknown	IFNGTE...	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15848
Q9UKR0-22-unknown	IFNGTE...	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16110
Q9UKR0-22-unknown	IFNGTE...	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16636
Q9UKR0-22-unknown	IFNGTE...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt136961
Q9UKR0-22-unknown	IFNGTE...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt136963

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AATPKI	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16395
...AATPKI	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15900
...AATPKI	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16679
...AATPKI	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16020
...AATPKI	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15814
...AATPKI	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15848
...AATPKI	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16110
...AATPKI	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16636
...AATPKI	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119789
...AATPKI	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119791
...IMRNN	248	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK4_HUMAN	21	TPKI.\|.IFNG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK13_HUMAN	21	TPKI.\|.IFNG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK8_HUMAN	21	TPKI.\|.IFNG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK14_HUMAN	21	TPKI.\|.IFNG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK11_HUMAN	21	TPKI.\|.IFNG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK12_HUMAN	21	TPKI.\|.IFNG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK2_HUMAN	21	TPKI.\|.IFNG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK6_HUMAN	21	TPKI.\|.IFNG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK15-Isoform4_HUMAN	21	GDKL.\|.LLEG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15838
KLK15-Isoform3_HUMAN	21	GDKL.\|.LLEG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15838
KLK15-Isoform2_HUMAN	21	GDKL.\|.LLEG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15838
KLK12-Isoform3_HUMAN	21	TPKI.\|.IFNG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15848
KLK11-Isoform4_HUMAN	21	ETRI.\|.IIKG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15843
KLK6_HUMAN	21	QNKL.\|.LVHG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK15_HUMAN	21	GDKL.\|.LLEG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK11-Isoform1_HUMAN	21	ETRI.\|.IIKG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15843
KLK12_HUMAN	21	TPKI.\|.IFNG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK12-Isoform2_HUMAN	21	TPKI.\|.IFNG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15848
KLK9_HUMAN	22	DTRA.\|.AIGA	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK3-Isoform5_HUMAN	24	LSRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15828
KLK3-Isoform4_HUMAN	24	LSRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15828
KLK3-Isoform3_HUMAN	24	LSRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15828
KLK2-Isoform3_HUMAN	24	QSRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15833
KLK2-Isoform2_HUMAN	24	QSRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15833
KLK1_HUMAN	24	QSRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK3-Isoform2_HUMAN	24	LSRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15828
KLK3_HUMAN	24	LSRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK2_HUMAN	24	QSRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK13_HUMAN	25	SSKV.\|.VLNT	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK7_HUMAN	29	GDKI.\|.IIDG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK8_HUMAN	32	EDKV.\|.VLGG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK14_HUMAN	40	ENKI.\|.IIGG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK10_HUMAN	42	DTRL.\|.LDPE	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK11-Isoform3_HUMAN	53	ETRI.\|.IIKG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15843
KLK11_HUMAN	53	ETRI.\|.IIKG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK5_HUMAN	66	SSRI.\|.IING	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
CCN1_HUMAN	88	ALKG.\|.GICR	inferred from experiment	unknown	MEROPS	Courty Y	Guillon-Munos A et al.:Kallikrein-related peptidase 12... (S01.020)	21628462,
CCN1_HUMAN	208	SLKR.\|.RLPV	inferred from experiment	unknown	MEROPS	Courty Y	Guillon-Munos A et al.:Kallikrein-related peptidase 12... (S01.020)	21628462,
WISP2_HUMAN	215	ATRV.\|.VSNQ	inferred from experiment	unknown	MEROPS	Courty Y	Guillon-Munos A et al.:Kallikrein-related peptidase 12... (S01.020)	21628462,
CCN1_HUMAN	218	EPRI.\|.ILYN	inferred from experiment	unknown	MEROPS	Courty Y	Guillon-Munos A et al.:Kallikrein-related peptidase 12... (S01.020)	21628462,
CCN1_HUMAN	290	KTKK.\|.KSPE	inferred from experiment	unknown	MEROPS	Courty Y	Guillon-Munos A et al.:Kallikrein-related peptidase 12... (S01.020)	21628462,
CCN1_HUMAN	345	FSKN.\|.NVMM	inferred from experiment	unknown	MEROPS	Courty Y	Guillon-Munos A et al.:Kallikrein-related peptidase 12... (S01.020)	21628462,

TopFIND

Q9UKR0: Kallikrein-12

General Information

3

N-termini

2

C-termini

8

Cleavages

34

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 8 Cleavages - 34 Substrates

N-termini

C-termini

Cleavages

Substrates