Q9H2R5: Kallikrein-15

General Information

Protein names	- Kallikrein-15 - 3.4.21.- - ACO protease
Gene names	KLK15
Organism	Homo sapiens
Protease Family	S01.081
Protease ID	S01.081
Chromosome location
UniProt ID	Q9H2R5

3 N-termini

3 C-termini

4 Cleavages

5 Substrates

Sequence

Isoforms

- Isoform 2 of Kallikrein-15 - Isoform 3 of Kallikrein-15 - Isoform 4 of Kallikrein-15 - Isoform 5 of Kallikrein-15

Sequence View

        10         20         30         40         50         60
MWLLLTLSFL LASTAAQDGD KLLEGDECAP HSQPWQVALY ERGRFNCGAS LISPHWVLSA
        70         80         90        100        110        120
AHCQSRFMRV RLGEHNLRKR DGPEQLRTTS RVIPHPRYEA RSHRNDIMLL RLVQPARLNP
       130        140        150        160        170        180
QVRPAVLPTR CPHPGEACVV SGWGLVSHNE PGTAGSPRSQ VSLPDTLHCA NISIISDTSC
       190        200        210        220        230        240
DKSYPGRLTN TMVCAGAEGR GAESCEGDSG GPLVCGGILQ GIVSWGDVPC DNTTKPGVYT
       250
KVCHYLEWIR ETMKRN         10         20         30         40         50         60
MWLLLTLSFL LASTAAQDGD KLLEGDECAP HSQPWQVALY ERGRFNCGAS LISPHWVLSA
        70         80         90        100        110        120
AHCQSRFMRV RLGEHNLRKR DGPEQLRTTS RVIPHPRYEA RSHRNDIMLL RLVQPARLNP
       130        140        150        160        170        180
QVRPAVLPTR CPHPGEACVV SGWGLVSHNE PGTAGSPRSQ VSLPDTLHCA NISIISDTSC
       190        200        210        220        230        240
DKSYPGRLTN TMVCAGAEGR GAESCEGDSG GPLVCGGILQ GIVSWGDVPC DNTTKPGVYT
       250
KVCHYLEWIR ETMKRN         10         20         30         40         50         60
MWLLLTLSFL LASTAAQDGD KLLEGDECAP HSQPWQVALY ERGRFNCGAS LISPHWVLSA
        70         80         90        100        110        120
AHCQSRFMRV RLGEHNLRKR DGPEQLRTTS RVIPHPRYEA RSHRNDIMLL RLVQPARLNP
       130        140        150        160        170        180
QVRPAVLPTR CPHPGEACVV SGWGLVSHNE PGTAGSPRSQ VSLPDTLHCA NISIISDTSC
       190        200        210        220        230        240
DKSYPGRLTN TMVCAGAEGR GAESCEGDSG GPLVCGGILQ GIVSWGDVPC DNTTKPGVYT
       250
KVCHYLEWIR ETMKRN         10         20         30         40         50         60
MWLLLTLSFL LASTAAQDGD KLLEGDECAP HSQPWQVALY ERGRFNCGAS LISPHWVLSA
        70         80         90        100        110        120
AHCQSRFMRV RLGEHNLRKR DGPEQLRTTS RVIPHPRYEA RSHRNDIMLL RLVQPARLNP
       130        140        150        160        170        180
QVRPAVLPTR CPHPGEACVV SGWGLVSHNE PGTAGSPRSQ VSLPDTLHCA NISIISDTSC
       190        200        210        220        230        240
DKSYPGRLTN TMVCAGAEGR GAESCEGDSG GPLVCGGILQ GIVSWGDVPC DNTTKPGVYT
       250
KVCHYLEWIR ETMKRN

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 4 Cleavages - 5 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9H2R5-1-unknown	MWLLLT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79140
Q9H2R5-1-unknown	MWLLLT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79141
Q9H2R5-1-unknown	MWLLLT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79142
Q9H2R5-17-unknown	QDGDKL...	17	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9H2R5-17-unknown	QDGDKL...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111823
Q9H2R5-17-unknown	QDGDKL...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111824
Q9H2R5-17-unknown	QDGDKL...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111825
Q9H2R5-17-unknown	QDGDKL...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111826
Q9H2R5-22-unknown	LLEGDE...	22	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9H2R5-22-unknown	LLEGDE...	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16385
Q9H2R5-22-unknown	LLEGDE...	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16483
Q9H2R5-22-unknown	LLEGDE...	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16003
Q9H2R5-22-unknown	LLEGDE...	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15838
Q9H2R5-22-unknown	LLEGDE...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112839
Q9H2R5-22-unknown	LLEGDE...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112840
Q9H2R5-22-unknown	LLEGDE...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112841
Q9H2R5-22-unknown	LLEGDE...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112842

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QDGDKL	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16385
...QDGDKL	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16483
...QDGDKL	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16003
...QDGDKL	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15838
...QDGDKL	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119769
...QDGDKL	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119770
...QDGDKL	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119773
...RLNPQV	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74758
...RLNPQV	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91583
...RLNPQV	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91584
...RLNPQV	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91585
...TMKRN	256	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TMKRN	256	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74760
...TMKRN	256	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74761

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK4_HUMAN	21	GDKL.\|.LLEG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK5_HUMAN	21	GDKL.\|.LLEG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK14_HUMAN	21	GDKL.\|.LLEG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK12_HUMAN	21	GDKL.\|.LLEG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK3_HUMAN	24	LSRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Deng T	Takayama TK et al.:Activation of prostate-specific... (S01.081)	11327827,
KLK3-Isoform5_HUMAN	24	LSRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC16025
KLK3-Isoform4_HUMAN	24	LSRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC16025
KLK3-Isoform3_HUMAN	24	LSRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC16025
KLK3-Isoform2_HUMAN	24	LSRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC16025