Q9UBX7: Kallikrein-11

General Information

Protein names	- Kallikrein-11 - hK11 - 3.4.21.- - Hippostasin - Serine protease 20 - Trypsin-like protease - Kallikrein-11 inactive chain 1 - Kallikrein-11 inactive chain 2
Gene names	KLK11
Organism	Homo sapiens
Protease Family	S01.257
Protease ID	S01.257
Chromosome location
UniProt ID	Q9UBX7

5 N-termini

3 C-termini

11 Cleavages

17 Substrates

Sequence

Isoforms

- Isoform 1 of Kallikrein-11 - Isoform 3 of Kallikrein-11 - Isoform 4 of Kallikrein-11

Sequence View

        10         20         30         40         50         60
MQRLRWLRDW KSSGRGLTAA KEPGARSSPL QAMRILQLIL LALATGLVGG ETRIIKGFEC
        70         80         90        100        110        120
KPHSQPWQAA LFEKTRLLCG ATLIAPRWLL TAAHCLKPRY IVHLGQHNLQ KEEGCEQTRT
       130        140        150        160        170        180
ATESFPHPGF NNSLPNKDHR NDIMLVKMAS PVSITWAVRP LTLSSRCVTA GTSCLISGWG
       190        200        210        220        230        240
STSSPQLRLP HTLRCANITI IEHQKCENAY PGNITDTMVC ASVQEGGKDS CQGDSGGPLV
       250        260        270        280
CNQSLQGIIS WGQDPCAITR KPGVYTKVCK YVDWIQETMK NN         10         20         30         40         50         60
MQRLRWLRDW KSSGRGLTAA KEPGARSSPL QAMRILQLIL LALATGLVGG ETRIIKGFEC
        70         80         90        100        110        120
KPHSQPWQAA LFEKTRLLCG ATLIAPRWLL TAAHCLKPRY IVHLGQHNLQ KEEGCEQTRT
       130        140        150        160        170        180
ATESFPHPGF NNSLPNKDHR NDIMLVKMAS PVSITWAVRP LTLSSRCVTA GTSCLISGWG
       190        200        210        220        230        240
STSSPQLRLP HTLRCANITI IEHQKCENAY PGNITDTMVC ASVQEGGKDS CQGDSGGPLV
       250        260        270        280
CNQSLQGIIS WGQDPCAITR KPGVYTKVCK YVDWIQETMK NN         10         20         30         40         50         60
MQRLRWLRDW KSSGRGLTAA KEPGARSSPL QAMRILQLIL LALATGLVGG ETRIIKGFEC
        70         80         90        100        110        120
KPHSQPWQAA LFEKTRLLCG ATLIAPRWLL TAAHCLKPRY IVHLGQHNLQ KEEGCEQTRT
       130        140        150        160        170        180
ATESFPHPGF NNSLPNKDHR NDIMLVKMAS PVSITWAVRP LTLSSRCVTA GTSCLISGWG
       190        200        210        220        230        240
STSSPQLRLP HTLRCANITI IEHQKCENAY PGNITDTMVC ASVQEGGKDS CQGDSGGPLV
       250        260        270        280
CNQSLQGIIS WGQDPCAITR KPGVYTKVCK YVDWIQETMK NN

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 11 Cleavages - 17 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9UBX7-1-unknown	MQRLRW...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79135
Q9UBX7-33-unknown	MRILQL...	33	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79136
Q9UBX7-33-unknown	MRILQL...	33	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97730
Q9UBX7-51-unknown	ETRIIK...	51	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9UBX7-51-unknown	ETRIIK...	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115641
Q9UBX7-51-unknown	ETRIIK...	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115642
Q9UBX7-54-unknown	IIKGFE...	54	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9UBX7-54-unknown	IIKGFE...	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16390
Q9UBX7-54-unknown	IIKGFE...	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15895
Q9UBX7-54-unknown	IIKGFE...	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16674
Q9UBX7-54-unknown	IIKGFE...	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16488
Q9UBX7-54-unknown	IIKGFE...	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16237
Q9UBX7-54-unknown	IIKGFE...	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16015
Q9UBX7-54-unknown	IIKGFE...	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15810
Q9UBX7-54-unknown	IIKGFE...	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15843
Q9UBX7-54-unknown	IIKGFE...	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16101
Q9UBX7-54-unknown	IIKGFE...	54	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115669
Q9UBX7-54-unknown	IIKGFE...	54	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115670
Q9UBX7-189-unknown	LPHTLR...	189	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9UBX7-189-unknown	LPHTLR...	189	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27606
Q9UBX7-189-unknown	LPHTLR...	189	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16105
Q9UBX7-189-unknown	LPHTLR...	189	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116000
Q9UBX7-189-unknown	LPHTLR...	189	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116001

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GGETRI	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16390
...GGETRI	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15895
...GGETRI	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16674
...GGETRI	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16488
...GGETRI	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16237
...GGETRI	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16015
...GGETRI	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15810
...GGETRI	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15843
...GGETRI	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16101
...GGETRI	53	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119779
...GGETRI	53	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122525
...SPQLRL	188	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SPQLRL	188	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27606
...SPQLRL	188	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16105
...SPQLRL	188	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91879
...SPQLRL	188	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91880
...TMKNN	282	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TMKNN	282	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74754
...TMKNN	282	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74753

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK4_HUMAN	53	ETRI.\|.IIKG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK13_HUMAN	53	ETRI.\|.IIKG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK8_HUMAN	53	ETRI.\|.IIKG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK5_HUMAN	53	ETRI.\|.IIKG	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Human tissue kallikrein 5 is a ... (S01.017)	16517595,
KLK3_HUMAN	53	ETRI.\|.IIKG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK14_HUMAN	53	ETRI.\|.IIKG	inferred from experiment	unknown	MEROPS	Diamandis EP	Emami N et al.:Human kallikrein-related peptid... (S01.029)	18056261,
KLK11_HUMAN	53	ETRI.\|.IIKG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK12_HUMAN	53	ETRI.\|.IIKG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK2_HUMAN	53	ETRI.\|.IIKG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
PLMN_HUMAN	188	QLRL.\|.LPHT	inferred from experiment	unknown	MEROPS	Diamandis EP	Luo LY et al.:Purification and characterizati... (S01.161)	16467084,
KLK2_HUMAN	188	QLRL.\|.LPHT	inferred from experiment	unknown	MEROPS	Diamandis EP	Luo LY et al.:Purification and characterizati... (S01.161)	16467084,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK6_HUMAN	21	QNKL.\|.LVHG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK11-Isoform4_HUMAN	21	ETRI.\|.IIKG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15810
KLK11-Isoform1_HUMAN	21	ETRI.\|.IIKG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15810
KLK12_HUMAN	21	TPKI.\|.IFNG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK12-Isoform3_HUMAN	21	TPKI.\|.IFNG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15814
KLK12-Isoform2_HUMAN	21	TPKI.\|.IFNG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15814
KLK1_HUMAN	24	QSRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK3_HUMAN	24	LSRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK3-Isoform5_HUMAN	24	LSRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15803
KLK3-Isoform4_HUMAN	24	LSRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15803
KLK3-Isoform3_HUMAN	24	LSRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15803
KLK3-Isoform2_HUMAN	24	LSRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15803
KLK4_HUMAN	30	CSQI.\|.IING	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK14_HUMAN	40	ENKI.\|.IIGG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK11_HUMAN	53	ETRI.\|.IIKG	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK11-Isoform3_HUMAN	53	ETRI.\|.IIKG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15810
KLK5_HUMAN	66	SSRI.\|.IING	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,