O43240: Kallikrein-10

General Information

Protein names	- Kallikrein-10 - 3.4.21.- - Normal epithelial cell-specific 1 - Protease serine-like 1
Gene names	KLK10
Organism	Homo sapiens
Protease Family
Protease ID	S01.246
Chromosome location
UniProt ID	O43240

2 N-termini

3 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRAPHLHLSA ASGARALAKL LPLLMAQLWA AEAALLPQND TRLDPEAYGS PCARGSQPWQ
        70         80         90        100        110        120
VSLFNGLSFH CAGVLVDQSW VLTAAHCGNK PLWARVGDDH LLLLQGEQLR RTTRSVVHPK
       130        140        150        160        170        180
YHQGSGPILP RRTDEHDLML LKLARPVVLG PRVRALQLPY RCAQPGDQCQ VAGWGTTAAR
       190        200        210        220        230        240
RVKYNKGLTC SSITILSPKE CEVFYPGVVT NNMICAGLDR GQDPCQSDSG GPLVCDETLQ
       250        260        270
GILSWGVYPC GSAQHPAVYT QICKYMSWIN KVIRSN

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O43240-31-unknown	AEAALL...	31	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O43240-43-unknown	LDPEAY...	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16400
O43240-43-unknown	LDPEAY...	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15906
O43240-43-unknown	LDPEAY...	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16509
O43240-43-unknown	LDPEAY...	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15824
O43240-43-unknown	LDPEAY...	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16115

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QNDTRL	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16400
...QNDTRL	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15906
...QNDTRL	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16509
...QNDTRL	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15824
...QNDTRL	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16115
...MLLKLA	143	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000471610
...VIRSN	276	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK5_HUMAN	42	DTRL.\|.LDPE	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK14_HUMAN	42	DTRL.\|.LDPE	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK6_HUMAN	42	DTRL.\|.LDPE	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK12_HUMAN	42	DTRL.\|.LDPE	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,
KLK3_HUMAN	42	DTRL.\|.LDPE	inferred from experiment	unknown	MEROPS	Blaber M	Yoon H et al.:Activation profiles and regulat... (S01.257)	17823117,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)