P49913: Cathelicidin antimicrobial peptide {ECO:0000312|HGNC:HGNC:1472}

General Information

Protein names	- Cathelicidin antimicrobial peptide {ECO:0000312\|HGNC:HGNC:1472} - 18 kDa cationic antimicrobial protein {ECO:0000303\|PubMed:7615076} - CAP-18 {ECO:0000303\|PubMed:7615076} - hCAP-18 {ECO:0000303\|PubMed:7615076} - Antibacterial peptide FALL-39 {ECO:0000303\|PubMed:7529412} - FALL-39 peptide antibiotic {ECO:0000303\|PubMed:7529412} - Antibacterial peptide LL-37 {ECO:0000303\|PubMed:8681941}
Gene names	CAMP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49913

11 N-termini

11 C-termini

14 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKTQRDGHSL GRWSLVLLLL GLVMPLAIIA QVLSYKEAVL RAIDGINQRS SDANLYRLLD
        70         80         90        100        110        120
LDPRPTMDGD PDTPKPVSFT VKETVCPRTT QQSPEDCDFK KDGLVKRCMG TVTLNQARGS
       130        140        150        160        170
FDISCDKDNK RFALLGDFFR KSKEKIGKEF KRIVQRIKDF LRNLVPRTES

Isoforms

Sequence View

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P49913-31-unknown	QVLSYK...	31	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49913-132-unknown	FALLGD...	132	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49913-134-unknown	LLGDFF...	134	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49913-134-unknown	LLGDFF...	134	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16465
P49913-134-unknown	LLGDFF...	134	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27792
P49913-134-unknown	LLGDFF...	134	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9452
P49913-139-unknown	FRKSKE...	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16504
P49913-139-unknown	FRKSKE...	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4595
P49913-140-unknown	RKSKEK...	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16505
P49913-141-unknown	KSKEKI...	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16466
P49913-151-unknown	KRIVQR...	151	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16506
P49913-153-unknown	IVQRIK...	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16467
P49913-157-unknown	IKDFLR...	157	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16468
P49913-161-unknown	LRNLVP...	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16507
P49913-161-unknown	LRNLVP...	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4596
P49913-163-unknown	NLVPRT...	163	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16469

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NKRFAL	133	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16465
...NKRFAL	133	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27792
...NKRFAL	133	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9452
...LLGDFF	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16504
...LLGDFF	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4595
...LGDFFR	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16505
...GDFFRK	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16466
...IGKEFK	150	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16506
...KEFKRI	152	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16467
...RIVQRI	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16468
...RIKDFL	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16507
...RIKDFL	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4596
...KDFLRN	162	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16469
...NLVPRT	167	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16470
...PRTES	170	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK5_HUMAN	133	RFAL.\|.LLGD	inferred from experiment	unknown	MEROPS	Gallo RL	Yamasaki K et al.:Kallikrein-mediated proteolysis... (S01.017)	17012259,
PRTN3_HUMAN	133	RFAL.\|.LLGD	inferred from experiment	unknown	MEROPS	Borregaard N	Sorensen OE et al.:Human cathelicidin, hCAP-18, is... (S01.131)	11389039,
ELNE_HUMAN	133	RFAL.\|.LLGD	inferred from experiment	unknown	MEROPS	Borregaard N	Sorensen OE et al.:Human cathelicidin, hCAP-18, is... (S01.131)	11389039,
KLK7_HUMAN	138	GDFF.\|.FRKS	inferred from experiment	unknown	MEROPS	Gallo RL	Yamasaki K et al.:Kallikrein-mediated proteolysis... (S01.017)	17012259,
CATD_HUMAN	138	GDFF.\|.FRKS	inferred from experiment	unknown	MEROPS	Kalbacher H	Baechle D et al.:Cathepsin D is present in human... (A01.009)	16354654,
KLK7_HUMAN	139	DFFR.\|.RKSK	inferred from experiment	unknown	MEROPS	Gallo RL	Yamasaki K et al.:Kallikrein-mediated proteolysis... (S01.017)	17012259,
KLK5_HUMAN	140	FFRK.\|.KSKE	inferred from experiment	unknown	MEROPS	Gallo RL	Yamasaki K et al.:Kallikrein-mediated proteolysis... (S01.017)	17012259,
KLK7_HUMAN	150	KEFK.\|.KRIV	inferred from experiment	unknown	MEROPS	Gallo RL	Yamasaki K et al.:Kallikrein-mediated proteolysis... (S01.017)	17012259,
KLK5_HUMAN	152	FKRI.\|.IVQR	inferred from experiment	unknown	MEROPS	Gallo RL	Yamasaki K et al.:Kallikrein-mediated proteolysis... (S01.017)	17012259,
KLK5_HUMAN	156	VQRI.\|.IKDF	inferred from experiment	unknown	MEROPS	Gallo RL	Yamasaki K et al.:Kallikrein-mediated proteolysis... (S01.017)	17012259,
KLK7_HUMAN	160	KDFL.\|.LRNL	inferred from experiment	unknown	MEROPS	Gallo RL	Yamasaki K et al.:Kallikrein-mediated proteolysis... (S01.017)	17012259,
CATD_HUMAN	160	KDFL.\|.LRNL	inferred from experiment	unknown	MEROPS	Kalbacher H	Baechle D et al.:Cathepsin D is present in human... (A01.009)	16354654,
KLK5_HUMAN	162	FLRN.\|.NLVP	inferred from experiment	unknown	MEROPS	Gallo RL	Yamasaki K et al.:Kallikrein-mediated proteolysis... (S01.017)	17012259,
KLK5_HUMAN	167	VPRT.\|.TES	inferred from experiment	unknown	MEROPS	Gallo RL	Yamasaki K et al.:Kallikrein-mediated proteolysis... (S01.017)	17012259,

TopFIND

P49913: Cathelicidin antimicrobial peptide {ECO:0000312|HGNC:HGNC:1472}

General Information

11

N-termini

11

C-termini

14

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 11 C-termini - 14 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates