O75309: Cadherin-16

General Information

Protein names	- Cadherin-16 - Kidney-specific cadherin - Ksp-cadherin
Gene names	CDH16
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75309

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Cadherin-16 - Isoform 3 of Cadherin-16 - Isoform 4 of Cadherin-16

Sequence View

        10         20         30         40         50         60
MVPAWLWLLC VSVPQALPKA QPAELSVEVP ENYGGNFPLY LTKLPLPREG AEGQIVLSGD
        70         80         90        100        110        120
SGKATEGPFA MDPDSGFLLV TRALDREEQA EYQLQVTLEM QDGHVLWGPQ PVLVHVKDEN
       130        140        150        160        170        180
DQVPHFSQAI YRARLSRGTR PGIPFLFLEA SDRDEPGTAN SDLRFHILSQ APAQPSPDMF
       190        200        210        220        230        240
QLEPRLGALA LSPKGSTSLD HALERTYQLL VQVKDMGDQA SGHQATATVE VSIIESTWVS
       250        260        270        280        290        300
LEPIHLAENL KVLYPHHMAQ VHWSGGDVHY HLESHPPGPF EVNAEGNLYV TRELDREAQA
       310        320        330        340        350        360
EYLLQVRAQN SHGEDYAAPL ELHVLVMDEN DNVPICPPRD PTVSIPELSP PGTEVTRLSA
       370        380        390        400        410        420
EDADAPGSPN SHVVYQLLSP EPEDGVEGRA FQVDPTSGSV TLGVLPLRAG QNILLLVLAM
       430        440        450        460        470        480
DLAGAEGGFS STCEVEVAVT DINDHAPEFI TSQIGPISLP EDVEPGTLVA MLTAIDADLE
       490        500        510        520        530        540
PAFRLMDFAI ERGDTEGTFG LDWEPDSGHV RLRLCKNLSY EAAPSHEVVV VVQSVAKLVG
       550        560        570        580        590        600
PGPGPGATAT VTVLVERVMP PPKLDQESYE ASVPISAPAG SFLLTIQPSD PISRTLRFSL
       610        620        630        640        650        660
VNDSEGWLCI EKFSGEVHTA QSLQGAQPGD TYTVLVEAQD TDEPRLSASA PLVIHFLKAP
       670        680        690        700        710        720
PAPALTLAPV PSQYLCTPRQ DHGLIVSGPS KDPDLASGHG PYSFTLGPNP TVQRDWRLQT
       730        740        750        760        770        780
LNGSHAYLTL ALHWVEPREH IIPVVVSHNA QMWQLLVRVI VCRCNVEGQC MRKVGRMKGM
       790        800        810        820
PTKLSAVGIL VGTLVAIGIF LILIFTHWTM SRKKDPDQPA DSVPLKATV         10         20         30         40         50         60
MVPAWLWLLC VSVPQALPKA QPAELSVEVP ENYGGNFPLY LTKLPLPREG AEGQIVLSGD
        70         80         90        100        110        120
SGKATEGPFA MDPDSGFLLV TRALDREEQA EYQLQVTLEM QDGHVLWGPQ PVLVHVKDEN
       130        140        150        160        170        180
DQVPHFSQAI YRARLSRGTR PGIPFLFLEA SDRDEPGTAN SDLRFHILSQ APAQPSPDMF
       190        200        210        220        230        240
QLEPRLGALA LSPKGSTSLD HALERTYQLL VQVKDMGDQA SGHQATATVE VSIIESTWVS
       250        260        270        280        290        300
LEPIHLAENL KVLYPHHMAQ VHWSGGDVHY HLESHPPGPF EVNAEGNLYV TRELDREAQA
       310        320        330        340        350        360
EYLLQVRAQN SHGEDYAAPL ELHVLVMDEN DNVPICPPRD PTVSIPELSP PGTEVTRLSA
       370        380        390        400        410        420
EDADAPGSPN SHVVYQLLSP EPEDGVEGRA FQVDPTSGSV TLGVLPLRAG QNILLLVLAM
       430        440        450        460        470        480
DLAGAEGGFS STCEVEVAVT DINDHAPEFI TSQIGPISLP EDVEPGTLVA MLTAIDADLE
       490        500        510        520        530        540
PAFRLMDFAI ERGDTEGTFG LDWEPDSGHV RLRLCKNLSY EAAPSHEVVV VVQSVAKLVG
       550        560        570        580        590        600
PGPGPGATAT VTVLVERVMP PPKLDQESYE ASVPISAPAG SFLLTIQPSD PISRTLRFSL
       610        620        630        640        650        660
VNDSEGWLCI EKFSGEVHTA QSLQGAQPGD TYTVLVEAQD TDEPRLSASA PLVIHFLKAP
       670        680        690        700        710        720
PAPALTLAPV PSQYLCTPRQ DHGLIVSGPS KDPDLASGHG PYSFTLGPNP TVQRDWRLQT
       730        740        750        760        770        780
LNGSHAYLTL ALHWVEPREH IIPVVVSHNA QMWQLLVRVI VCRCNVEGQC MRKVGRMKGM
       790        800        810        820
PTKLSAVGIL VGTLVAIGIF LILIFTHWTM SRKKDPDQPA DSVPLKATV         10         20         30         40         50         60
MVPAWLWLLC VSVPQALPKA QPAELSVEVP ENYGGNFPLY LTKLPLPREG AEGQIVLSGD
        70         80         90        100        110        120
SGKATEGPFA MDPDSGFLLV TRALDREEQA EYQLQVTLEM QDGHVLWGPQ PVLVHVKDEN
       130        140        150        160        170        180
DQVPHFSQAI YRARLSRGTR PGIPFLFLEA SDRDEPGTAN SDLRFHILSQ APAQPSPDMF
       190        200        210        220        230        240
QLEPRLGALA LSPKGSTSLD HALERTYQLL VQVKDMGDQA SGHQATATVE VSIIESTWVS
       250        260        270        280        290        300
LEPIHLAENL KVLYPHHMAQ VHWSGGDVHY HLESHPPGPF EVNAEGNLYV TRELDREAQA
       310        320        330        340        350        360
EYLLQVRAQN SHGEDYAAPL ELHVLVMDEN DNVPICPPRD PTVSIPELSP PGTEVTRLSA
       370        380        390        400        410        420
EDADAPGSPN SHVVYQLLSP EPEDGVEGRA FQVDPTSGSV TLGVLPLRAG QNILLLVLAM
       430        440        450        460        470        480
DLAGAEGGFS STCEVEVAVT DINDHAPEFI TSQIGPISLP EDVEPGTLVA MLTAIDADLE
       490        500        510        520        530        540
PAFRLMDFAI ERGDTEGTFG LDWEPDSGHV RLRLCKNLSY EAAPSHEVVV VVQSVAKLVG
       550        560        570        580        590        600
PGPGPGATAT VTVLVERVMP PPKLDQESYE ASVPISAPAG SFLLTIQPSD PISRTLRFSL
       610        620        630        640        650        660
VNDSEGWLCI EKFSGEVHTA QSLQGAQPGD TYTVLVEAQD TDEPRLSASA PLVIHFLKAP
       670        680        690        700        710        720
PAPALTLAPV PSQYLCTPRQ DHGLIVSGPS KDPDLASGHG PYSFTLGPNP TVQRDWRLQT
       730        740        750        760        770        780
LNGSHAYLTL ALHWVEPREH IIPVVVSHNA QMWQLLVRVI VCRCNVEGQC MRKVGRMKGM
       790        800        810        820
PTKLSAVGIL VGTLVAIGIF LILIFTHWTM SRKKDPDQPA DSVPLKATV

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O75309-1-unknown	MVPAWL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt69123
O75309-1-unknown	MVPAWL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt69124
O75309-1-unknown	MVPAWL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt69125
O75309-19-unknown	KAQPAE...	19	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O75309-19-unknown	KAQPAE...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112240
O75309-19-unknown	KAQPAE...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112241
O75309-19-unknown	KAQPAE...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112242
O75309-514-unknown	LCKNLS...	514	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15855
O75309-514-unknown	LCKNLS...	514	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152289
O75309-514-unknown	LCKNLS...	514	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153588
O75309-514-unknown	LCKNLS...	514	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153589

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HVRLRL	513	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15855
...HVRLRL	513	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135699
...HVRLRL	513	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137011
...HVRLRL	513	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137012
...LKATV	829	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LKATV	829	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64742
...LKATV	829	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64743
...LKATV	829	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64741

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK13_HUMAN	513	RLRL.\|.LCKN	inferred from experiment	unknown	MEROPS	Diamandis EP	Borgono CA et al.:Defining the extended substrate... (S01.306)	17976015,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)