P98160: Basement membrane-specific heparan sulfate proteoglycan core protein

General Information

Protein names	- Basement membrane-specific heparan sulfate proteoglycan core protein - HSPG - Perlecan - PLC - Endorepellin - LG3 peptide
Gene names	HSPG2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P98160

7 N-termini

6 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGWRAAGALL LALLLHGRLL AVTHGLRAYD GLSLPEDIET VTASQMRWTH SYLSDDEDML
        70         80         90        100        110        120
ADSISGDDLG SGDLGSGDFQ MVYFRALVNF TRSIEYSPQL EDAGSREFRE VSEAVVDTLE
       130        140        150        160        170        180
SEYLKIPGDQ VVSVVFIKEL DGWVFVELDV GSEGNADGAQ IQEMLLRVIS SGSVASYVTS
       190        200        210        220        230        240
PQGFQFRRLG TVPQFPRACT EAEFACHSYN ECVALEYRCD RRPDCRDMSD ELNCEEPVLG
       250        260        270        280        290        300
ISPTFSLLVE TTSLPPRPET TIMRQPPVTH APQPLLPGSV RPLPCGPQEA ACRNGHCIPR
       310        320        330        340        350        360
DYLCDGQEDC EDGSDELDCG PPPPCEPNEF PCGNGHCALK LWRCDGDFDC EDRTDEANCP
       370        380        390        400        410        420
TKRPEEVCGP TQFRCVSTNM CIPASFHCDE ESDCPDRSDE FGCMPPQVVT PPRESIQASR
       430        440        450        460        470        480
GQTVTFTCVA IGVPTPIINW RLNWGHIPSH PRVTVTSEGG RGTLIIRDVK ESDQGAYTCE
       490        500        510        520        530        540
AMNARGMVFG IPDGVLELVP QRGPCPDGHF YLEHSAACLP CFCFGITSVC QSTRRFRDQI
       550        560        570        580        590        600
RLRFDQPDDF KGVNVTMPAQ PGTPPLSSTQ LQIDPSLHEF QLVDLSRRFL VHDSFWALPE
       610        620        630        640        650        660
QFLGNKVDSY GGSLRYNVRY ELARGMLEPV QRPDVVLMGA GYRLLSRGHT PTQPGALNQR
       670        680        690        700        710        720
QVQFSEEHWV HESGRPVQRA ELLQVLQSLE AVLIQTVYNT KMASVGLSDI AMDTTVTHAT
       730        740        750        760        770        780
SHGRAHSVEE CRCPIGYSGL SCESCDAHFT RVPGGPYLGT CSGCNCNGHA SSCDPVYGHC
       790        800        810        820        830        840
LNCQHNTEGP QCNKCKAGFF GDAMKATATS CRPCPCPYID ASRRFSDTCF LDTDGQATCD
       850        860        870        880        890        900
ACAPGYTGRR CESCAPGYEG NPIQPGGKCR PVNQEIVRCD ERGSMGTSGE ACRCKNNVVG
       910        920        930        940        950        960
RLCNECADGS FHLSTRNPDG CLKCFCMGVS RHCTSSSWSR AQLHGASEEP GHFSLTNAAS
       970        980        990       1000       1010       1020
THTTNEGIFS PTPGELGFSS FHRLLSGPYF WSLPSRFLGD KVTSYGGELR FTVTQRSQPG
      1030       1040       1050       1060       1070       1080
STPLHGQPLV VLQGNNIILE HHVAQEPSPG QPSTFIVPFR EQAWQRPDGQ PATREHLLMA
      1090       1100       1110       1120       1130       1140
LAGIDTLLIR ASYAQQPAES RVSGISMDVA VPEETGQDPA LEVEQCSCPP GYRGPSCQDC
      1150       1160       1170       1180       1190       1200
DTGYTRTPSG LYLGTCERCS CHGHSEACEP ETGACQGCQH HTEGPRCEQC QPGYYGDAQR
      1210       1220       1230       1240       1250       1260
GTPQDCQLCP CYGDPAAGQA AHTCFLDTDG HPTCDACSPG HSGRHCERCA PGYYGNPSQG
      1270       1280       1290       1300       1310       1320
QPCQRDSQVP GPIGCNCDPQ GSVSSQCDAA GQCQCKAQVE GLTCSHCRPH HFHLSASNPD
      1330       1340       1350       1360       1370       1380
GCLPCFCMGI TQQCASSAYT RHLISTHFAP GDFQGFALVN PQRNSRLTGE FTVEPVPEGA
      1390       1400       1410       1420       1430       1440
QLSFGNFAQL GHESFYWQLP ETYQGDKVAA YGGKLRYTLS YTAGPQGSPL SDPDVQITGN
      1450       1460       1470       1480       1490       1500
NIMLVASQPA LQGPERRSYE IMFREEFWRR PDGQPATREH LLMALADLDE LLIRATFSSV
      1510       1520       1530       1540       1550       1560
PLAASISAVS LEVAQPGPSN RPRALEVEEC RCPPGYIGLS CQDCAPGYTR TGSGLYLGHC
      1570       1580       1590       1600       1610       1620
ELCECNGHSD LCHPETGACS QCQHNAAGEF CELCAPGYYG DATAGTPEDC QPCACPLTNP
      1630       1640       1650       1660       1670       1680
ENMFSRTCES LGAGGYRCTA CEPGYTGQYC EQCGPGYVGN PSVQGGQCLP ETNQAPLVVE
      1690       1700       1710       1720       1730       1740
VHPARSIVPQ GGSHSLRCQV SGSPPHYFYW SREDGRPVPS GTQQRHQGSE LHFPSVQPSD
      1750       1760       1770       1780       1790       1800
AGVYICTCRN LHQSNTSRAE LLVTEAPSKP ITVTVEEQRS QSVRPGADVT FICTAKSKSP
      1810       1820       1830       1840       1850       1860
AYTLVWTRLH NGKLPTRAMD FNGILTIRNV QLSDAGTYVC TGSNMFAMDQ GTATLHVQAS
      1870       1880       1890       1900       1910       1920
GTLSAPVVSI HPPQLTVQPG QLAEFRCSAT GSPTPTLEWT GGPGGQLPAK AQIHGGILRL
      1930       1940       1950       1960       1970       1980
PAVEPTDQAQ YLCRAHSSAG QQVARAVLHV HGGGGPRVQV SPERTQVHAG RTVRLYCRAA
      1990       2000       2010       2020       2030       2040
GVPSATITWR KEGGSLPPQA RSERTDIATL LIPAITTADA GFYLCVATSP AGTAQARIQV
      2050       2060       2070       2080       2090       2100
VVLSASDASP PPVKIESSSP SVTEGQTLDL NCVVAGSAHA QVTWYRRGGS LPPHTQVHGS
      2110       2120       2130       2140       2150       2160
RLRLPQVSPA DSGEYVCRVE NGSGPKEASI TVSVLHGTHS GPSYTPVPGS TRPIRIEPSS
      2170       2180       2190       2200       2210       2220
SHVAEGQTLD LNCVVPGQAH AQVTWHKRGG SLPARHQTHG SLLRLHQVTP ADSGEYVCHV
      2230       2240       2250       2260       2270       2280
VGTSGPLEAS VLVTIEASVI PGPIPPVRIE SSSSTVAEGQ TLDLSCVVAG QAHAQVTWYK
      2290       2300       2310       2320       2330       2340
RGGSLPARHQ VRGSRLYIFQ ASPADAGQYV CRASNGMEAS ITVTVTGTQG ANLAYPAGST
      2350       2360       2370       2380       2390       2400
QPIRIEPSSS QVAEGQTLDL NCVVPGQSHA QVTWHKRGGS LPVRHQTHGS LLRLYQASPA
      2410       2420       2430       2440       2450       2460
DSGEYVCRVL GSSVPLEASV LVTIEPAGSV PALGVTPTVR IESSSSQVAE GQTLDLNCLV
      2470       2480       2490       2500       2510       2520
AGQAHAQVTW HKRGGSLPAR HQVHGSRLRL LQVTPADSGE YVCRVVGSSG TQEASVLVTI
      2530       2540       2550       2560       2570       2580
QQRLSGSHSQ GVAYPVRIES SSASLANGHT LDLNCLVASQ APHTITWYKR GGSLPSRHQI
      2590       2600       2610       2620       2630       2640
VGSRLRIPQV TPADSGEYVC HVSNGAGSRE TSLIVTIQGS GSSHVPSVSP PIRIESSSPT
      2650       2660       2670       2680       2690       2700
VVEGQTLDLN CVVARQPQAI ITWYKRGGSL PSRHQTHGSH LRLHQMSVAD SGEYVCRANN
      2710       2720       2730       2740       2750       2760
NIDALEASIV ISVSPSAGSP SAPGSSMPIR IESSSSHVAE GETLDLNCVV PGQAHAQVTW
      2770       2780       2790       2800       2810       2820
HKRGGSLPSH HQTRGSRLRL HHVSPADSGE YVCRVMGSSG PLEASVLVTI EASGSSAVHV
      2830       2840       2850       2860       2870       2880
PAPGGAPPIR IEPSSSRVAE GQTLDLKCVV PGQAHAQVTW HKRGGNLPAR HQVHGPLLRL
      2890       2900       2910       2920       2930       2940
NQVSPADSGE YSCQVTGSSG TLEASVLVTI EPSSPGPIPA PGLAQPIYIE ASSSHVTEGQ
      2950       2960       2970       2980       2990       3000
TLDLNCVVPG QAHAQVTWYK RGGSLPARHQ THGSQLRLHL VSPADSGEYV CRAASGPGPE
      3010       3020       3030       3040       3050       3060
QEASFTVTVP PSEGSSYRLR SPVISIDPPS STVQQGQDAS FKCLIHDGAA PISLEWKTRN
      3070       3080       3090       3100       3110       3120
QELEDNVHIS PNGSIITIVG TRPSNHGTYR CVASNAYGVA QSVVNLSVHG PPTVSVLPEG
      3130       3140       3150       3160       3170       3180
PVWVKVGKAV TLECVSAGEP RSSARWTRIS STPAKLEQRT YGLMDSHAVL QISSAKPSDA
      3190       3200       3210       3220       3230       3240
GTYVCLAQNA LGTAQKQVEV IVDTGAMAPG APQVQAEEAE LTVEAGHTAT LRCSATGSPA
      3250       3260       3270       3280       3290       3300
PTIHWSKLRS PLPWQHRLEG DTLIIPRVAQ QDSGQYICNA TSPAGHAEAT IILHVESPPY
      3310       3320       3330       3340       3350       3360
ATTVPEHASV QAGETVQLQC LAHGTPPLTF QWSRVGSSLP GRATARNELL HFERAAPEDS
      3370       3380       3390       3400       3410       3420
GRYRCRVTNK VGSAEAFAQL LVQGPPGSLP ATSIPAGSTP TVQVTPQLET KSIGASVEFH
      3430       3440       3450       3460       3470       3480
CAVPSDRGTQ LRWFKEGGQL PPGHSVQDGV LRIQNLDQSC QGTYICQAHG PWGKAQASAQ
      3490       3500       3510       3520       3530       3540
LVIQALPSVL INIRTSVQTV VVGHAVEFEC LALGDPKPQV TWSKVGGHLR PGIVQSGGVV
      3550       3560       3570       3580       3590       3600
RIAHVELADA GQYRCTATNA AGTTQSHVLL LVQALPQISM PQEVRVPAGS AAVFPCIASG
      3610       3620       3630       3640       3650       3660
YPTPDISWSK LDGSLPPDSR LENNMLMLPS VRPQDAGTYV CTATNRQGKV KAFAHLQVPE
      3670       3680       3690       3700       3710       3720
RVVPYFTQTP YSFLPLPTIK DAYRKFEIKI TFRPDSADGM LLYNGQKRVP GSPTNLANRQ
      3730       3740       3750       3760       3770       3780
PDFISFGLVG GRPEFRFDAG SGMATIRHPT PLALGHFHTV TLLRSLTQGS LIVGDLAPVN
      3790       3800       3810       3820       3830       3840
GTSQGKFQGL DLNEELYLGG YPDYGAIPKA GLSSGFIGCV RELRIQGEEI VFHDLNLTAH
      3850       3860       3870       3880       3890       3900
GISHCPTCRD RPCQNGGQCH DSESSSYVCV CPAGFTGSRC EHSQALHCHP EACGPDATCV
      3910       3920       3930       3940       3950       3960
NRPDGRGYTC RCHLGRSGLR CEEGVTVTTP SLSGAGSYLA LPALTNTHHE LRLDVEFKPL
      3970       3980       3990       4000       4010       4020
APDGVLLFSG GKSGPVEDFV SLAMVGGHLE FRYELGSGLA VLRSAEPLAL GRWHRVSAER
      4030       4040       4050       4060       4070       4080
LNKDGSLRVN GGRPVLRSSP GKSQGLNLHT LLYLGGVEPS VPLSPATNMS AHFRGCVGEV
      4090       4100       4110       4120       4130       4140
SVNGKRLDLT YSFLGSQGIG QCYDSSPCER QPCQHGATCM PAGEYEFQCL CRDGFKGDLC
      4150       4160       4170       4180       4190       4200
EHEENPCQLR EPCLHGGTCQ GTRCLCLPGF SGPRCQQGSG HGIAESDWHL EGSGGNDAPG
      4210       4220       4230       4240       4250       4260
QYGAYFHDDG FLAFPGHVFS RSLPEVPETI ELEVRTSTAS GLLLWQGVEV GEAGQGKDFI
      4270       4280       4290       4300       4310       4320
SLGLQDGHLV FRYQLGSGEA RLVSEDPIND GEWHRVTALR EGRRGSIQVD GEELVSGRSP
      4330       4340       4350       4360       4370       4380
GPNVAVNAKG SVYIGGAPDV ATLTGGRFSS GITGCVKNLV LHSARPGAPP PQPLDLQHRA
      4390
QAGANTRPCP S

Isoforms

Sequence View

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Evidence Codes:

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Protein Neighborhood

Domains & Features

7 N-termini - 6 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P98160-22-unknown	VTHGLR...	22	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P98160-22-unknown	VTHGLR...	22	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405412
P98160-35-unknown	PEDIET...	35	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000395884
P98160-1092-unknown	SYAQQP...	1092		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P98160-2051-unknown	PPVKIE...	2051	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000416385
P98160-2334-unknown	AYPAGS...	2334		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P98160-3687-unknown	EIKITF...	3687	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P98160-4197-unknown	DAPGQY...	4197	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P98160-4197-unknown	DAPGQY...	4197	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC683

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FDCEDR	352	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000363805
...SGEYVC	2217	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000416385
...SGEYVC	2792	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396310
...VRPQDA	3635	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000392022
...GSGGND	4196	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC683
...RPCPS	4391	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
BMP1_HUMAN	4196	GGND.\|.DAPG	inferred from experiment	unknown	MEROPS	Iozzo RV	Gonzalez EM et al.:BMP-1/Tolloid-like metalloprote... (M12.005)	15591058,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)