P58215: Lysyl oxidase homolog 3 {ECO:0000305}

General Information

Protein names	- Lysyl oxidase homolog 3 {ECO:0000305} - 1.4.3.- {ECO:0000269\|PubMed:28065600} - 1.4.3.13 {ECO:0000269\|PubMed:28065600} - Lysyl oxidase-like protein 3 {ECO:0000303\|PubMed:11386757}
Gene names	LOXL3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P58215

4 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Lysyl oxidase homolog 3 - Isoform 3 of Lysyl oxidase homolog 3

Sequence View

        10         20         30         40         50         60
MRPVSVWQWS PWGLLLCLLC SSCLGSPSPS TGPEKKAGSQ GLRFRLAGFP RKPYEGRVEI
        70         80         90        100        110        120
QRAGEWGTIC DDDFTLQAAH ILCRELGFTE ATGWTHSAKY GPGTGRIWLD NLSCSGTEQS
       130        140        150        160        170        180
VTECASRGWG NSDCTHDEDA GVICKDQRLP GFSDSNVIEV EHHLQVEEVR IRPAVGWGRR
       190        200        210        220        230        240
PLPVTEGLVE VRLPDGWSQV CDKGWSAHNS HVVCGMLGFP SEKRVNAAFY RLLAQRQQHS
       250        260        270        280        290        300
FGLHGVACVG TEAHLSLCSL EFYRANDTAR CPGGGPAVVS CVPGPVYAAS SGQKKQQQSK
       310        320        330        340        350        360
PQGEARVRLK GGAHPGEGRV EVLKASTWGT VCDRKWDLHA ASVVCRELGF GSAREALSGA
       370        380        390        400        410        420
RMGQGMGAIH LSEVRCSGQE LSLWKCPHKN ITAEDCSHSQ DAGVRCNLPY TGAETRIRLS
       430        440        450        460        470        480
GGRSQHEGRV EVQIGGPGPL RWGLICGDDW GTLEAMVACR QLGLGYANHG LQETWYWDSG
       490        500        510        520        530        540
NITEVVMSGV RCTGTELSLD QCAHHGTHIT CKRTGTRFTA GVICSETASD LLLHSALVQE
       550        560        570        580        590        600
TAYIEDRPLH MLYCAAEENC LASSARSANW PYGHRRLLRF SSQIHNLGRA DFRPKAGRHS
       610        620        630        640        650        660
WVWHECHGHY HSMDIFTHYD ILTPNGTKVA EGHKASFCLE DTECQEDVSK RYECANFGEQ
       670        680        690        700        710        720
GITVGCWDLY RHDIDCQWID ITDVKPGNYI LQVVINPNFE VAESDFTNNA MKCNCKYDGH
       730        740        750
RIWVHNCHIG DAFSEEANRR FERYPGQTSN QII         10         20         30         40         50         60
MRPVSVWQWS PWGLLLCLLC SSCLGSPSPS TGPEKKAGSQ GLRFRLAGFP RKPYEGRVEI
        70         80         90        100        110        120
QRAGEWGTIC DDDFTLQAAH ILCRELGFTE ATGWTHSAKY GPGTGRIWLD NLSCSGTEQS
       130        140        150        160        170        180
VTECASRGWG NSDCTHDEDA GVICKDQRLP GFSDSNVIEV EHHLQVEEVR IRPAVGWGRR
       190        200        210        220        230        240
PLPVTEGLVE VRLPDGWSQV CDKGWSAHNS HVVCGMLGFP SEKRVNAAFY RLLAQRQQHS
       250        260        270        280        290        300
FGLHGVACVG TEAHLSLCSL EFYRANDTAR CPGGGPAVVS CVPGPVYAAS SGQKKQQQSK
       310        320        330        340        350        360
PQGEARVRLK GGAHPGEGRV EVLKASTWGT VCDRKWDLHA ASVVCRELGF GSAREALSGA
       370        380        390        400        410        420
RMGQGMGAIH LSEVRCSGQE LSLWKCPHKN ITAEDCSHSQ DAGVRCNLPY TGAETRIRLS
       430        440        450        460        470        480
GGRSQHEGRV EVQIGGPGPL RWGLICGDDW GTLEAMVACR QLGLGYANHG LQETWYWDSG
       490        500        510        520        530        540
NITEVVMSGV RCTGTELSLD QCAHHGTHIT CKRTGTRFTA GVICSETASD LLLHSALVQE
       550        560        570        580        590        600
TAYIEDRPLH MLYCAAEENC LASSARSANW PYGHRRLLRF SSQIHNLGRA DFRPKAGRHS
       610        620        630        640        650        660
WVWHECHGHY HSMDIFTHYD ILTPNGTKVA EGHKASFCLE DTECQEDVSK RYECANFGEQ
       670        680        690        700        710        720
GITVGCWDLY RHDIDCQWID ITDVKPGNYI LQVVINPNFE VAESDFTNNA MKCNCKYDGH
       730        740        750
RIWVHNCHIG DAFSEEANRR FERYPGQTSN QII

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P58215-1-unknown	MRPVSV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79795
P58215-26-unknown	SPSPST...	26	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P58215-26-unknown	SPSPST...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114003
P58215-362-unknown	MGQGMG...	362	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79794
P58215-362-unknown	MGQGMG...	362	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105833
P58215-448-unknown	DDWGTL...	448	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC680
P58215-448-unknown	DDWGTL...	448	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141673
P58215-448-unknown	DDWGTL...	448	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149959

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SKPQGE	303	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000398260
...GLICGD	447	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC680
...GLICGD	447	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124855
...GLICGD	447	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133351
...DWGTLE	453	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000404026
...DWGTLE	453	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt110746
...DWGTLE	453	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt110747
...SNQII	753	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SNQII	753	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75412
...SNQII	753	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75413

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
BMP1_HUMAN	447	ICGD.\|.DDWG	inferred from experiment	unknown	MEROPS	Kim Y	Lee JE et al.:A tissue-specific variant of th... (M12.005)	17018530,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)