Q9H2X0: Chordin

General Information

Protein names	- Chordin
Gene names	CHRD
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H2X0

4 N-termini

3 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Chordin - Isoform 3 of Chordin - Isoform 4 of Chordin - Isoform 5 of Chordin

Sequence View

        10         20         30         40         50         60
MPSLPAPPAP LLLLGLLLLG SRPARGAGPE PPVLPIRSEK EPLPVRGAAG CTFGGKVYAL
        70         80         90        100        110        120
DETWHPDLGE PFGVMRCVLC ACEAPQWGRR TRGPGRVSCK NIKPECPTPA CGQPRQLPGH
       130        140        150        160        170        180
CCQTCPQERS SSERQPSGLS FEYPRDPEHR SYSDRGEPGA EERARGDGHT DFVALLTGPR
       190        200        210        220        230        240
SQAVARARVS LLRSSLRFSI SYRRLDRPTR IRFSDSNGSV LFEHPAAPTQ DGLVCGVWRA
       250        260        270        280        290        300
VPRLSLRLLR AEQLHVALVT LTHPSGEVWG PLIRHRALAA ETFSAILTLE GPPQQGVGGI
       310        320        330        340        350        360
TLLTLSDTED SLHFLLLFRG LLEPRSGGLT QVPLRLQILH QGQLLRELQA NVSAQEPGFA
       370        380        390        400        410        420
EVLPNLTVQE MDWLVLGELQ MALEWAGRPG LRISGHIAAR KSCDVLQSVL CGADALIPVQ
       430        440        450        460        470        480
TGAAGSASLT LLGNGSLIYQ VQVVGTSSEV VAMTLETKPQ RRDQRTVLCH MAGLQPGGHT
       490        500        510        520        530        540
AVGICPGLGA RGAHMLLQNE LFLNVGTKDF PDGELRGHVA ALPYCGHSAR HDTLPVPLAG
       550        560        570        580        590        600
ALVLPPVKSQ AAGHAWLSLD THCHLHYEVL LAGLGGSEQG TVTAHLLGPP GTPGPRRLLK
       610        620        630        640        650        660
GFYGSEAQGV VKDLEPELLR HLAKGMASLM ITTKGSPRGE LRGQVHIANQ CEVGGLRLEA
       670        680        690        700        710        720
AGAEGVRALG APDTASAAPP VVPGLPALAP AKPGGPGRPR DPNTCFFEGQ QRPHGARWAP
       730        740        750        760        770        780
NYDPLCSLCT CQRRTVICDP VVCPPPSCPH PVQAPDQCCP VCPEKQDVRD LPGLPRSRDP
       790        800        810        820        830        840
GEGCYFDGDR SWRAAGTRWH PVVPPFGLIK CAVCTCKGGT GEVHCEKVQC PRLACAQPVR
       850        860        870        880        890        900
VNPTDCCKQC PVGSGAHPQL GDPMQADGPR GCRFAGQWFP ESQSWHPSVP PFGEMSCITC
       910        920        930        940        950
RCGAGVPHCE RDDCSLPLSC GSGKESRCCS RCTAHRRPAP ETRTDPELEK EAEGS         10         20         30         40         50         60
MPSLPAPPAP LLLLGLLLLG SRPARGAGPE PPVLPIRSEK EPLPVRGAAG CTFGGKVYAL
        70         80         90        100        110        120
DETWHPDLGE PFGVMRCVLC ACEAPQWGRR TRGPGRVSCK NIKPECPTPA CGQPRQLPGH
       130        140        150        160        170        180
CCQTCPQERS SSERQPSGLS FEYPRDPEHR SYSDRGEPGA EERARGDGHT DFVALLTGPR
       190        200        210        220        230        240
SQAVARARVS LLRSSLRFSI SYRRLDRPTR IRFSDSNGSV LFEHPAAPTQ DGLVCGVWRA
       250        260        270        280        290        300
VPRLSLRLLR AEQLHVALVT LTHPSGEVWG PLIRHRALAA ETFSAILTLE GPPQQGVGGI
       310        320        330        340        350        360
TLLTLSDTED SLHFLLLFRG LLEPRSGGLT QVPLRLQILH QGQLLRELQA NVSAQEPGFA
       370        380        390        400        410        420
EVLPNLTVQE MDWLVLGELQ MALEWAGRPG LRISGHIAAR KSCDVLQSVL CGADALIPVQ
       430        440        450        460        470        480
TGAAGSASLT LLGNGSLIYQ VQVVGTSSEV VAMTLETKPQ RRDQRTVLCH MAGLQPGGHT
       490        500        510        520        530        540
AVGICPGLGA RGAHMLLQNE LFLNVGTKDF PDGELRGHVA ALPYCGHSAR HDTLPVPLAG
       550        560        570        580        590        600
ALVLPPVKSQ AAGHAWLSLD THCHLHYEVL LAGLGGSEQG TVTAHLLGPP GTPGPRRLLK
       610        620        630        640        650        660
GFYGSEAQGV VKDLEPELLR HLAKGMASLM ITTKGSPRGE LRGQVHIANQ CEVGGLRLEA
       670        680        690        700        710        720
AGAEGVRALG APDTASAAPP VVPGLPALAP AKPGGPGRPR DPNTCFFEGQ QRPHGARWAP
       730        740        750        760        770        780
NYDPLCSLCT CQRRTVICDP VVCPPPSCPH PVQAPDQCCP VCPEKQDVRD LPGLPRSRDP
       790        800        810        820        830        840
GEGCYFDGDR SWRAAGTRWH PVVPPFGLIK CAVCTCKGGT GEVHCEKVQC PRLACAQPVR
       850        860        870        880        890        900
VNPTDCCKQC PVGSGAHPQL GDPMQADGPR GCRFAGQWFP ESQSWHPSVP PFGEMSCITC
       910        920        930        940        950
RCGAGVPHCE RDDCSLPLSC GSGKESRCCS RCTAHRRPAP ETRTDPELEK EAEGS         10         20         30         40         50         60
MPSLPAPPAP LLLLGLLLLG SRPARGAGPE PPVLPIRSEK EPLPVRGAAG CTFGGKVYAL
        70         80         90        100        110        120
DETWHPDLGE PFGVMRCVLC ACEAPQWGRR TRGPGRVSCK NIKPECPTPA CGQPRQLPGH
       130        140        150        160        170        180
CCQTCPQERS SSERQPSGLS FEYPRDPEHR SYSDRGEPGA EERARGDGHT DFVALLTGPR
       190        200        210        220        230        240
SQAVARARVS LLRSSLRFSI SYRRLDRPTR IRFSDSNGSV LFEHPAAPTQ DGLVCGVWRA
       250        260        270        280        290        300
VPRLSLRLLR AEQLHVALVT LTHPSGEVWG PLIRHRALAA ETFSAILTLE GPPQQGVGGI
       310        320        330        340        350        360
TLLTLSDTED SLHFLLLFRG LLEPRSGGLT QVPLRLQILH QGQLLRELQA NVSAQEPGFA
       370        380        390        400        410        420
EVLPNLTVQE MDWLVLGELQ MALEWAGRPG LRISGHIAAR KSCDVLQSVL CGADALIPVQ
       430        440        450        460        470        480
TGAAGSASLT LLGNGSLIYQ VQVVGTSSEV VAMTLETKPQ RRDQRTVLCH MAGLQPGGHT
       490        500        510        520        530        540
AVGICPGLGA RGAHMLLQNE LFLNVGTKDF PDGELRGHVA ALPYCGHSAR HDTLPVPLAG
       550        560        570        580        590        600
ALVLPPVKSQ AAGHAWLSLD THCHLHYEVL LAGLGGSEQG TVTAHLLGPP GTPGPRRLLK
       610        620        630        640        650        660
GFYGSEAQGV VKDLEPELLR HLAKGMASLM ITTKGSPRGE LRGQVHIANQ CEVGGLRLEA
       670        680        690        700        710        720
AGAEGVRALG APDTASAAPP VVPGLPALAP AKPGGPGRPR DPNTCFFEGQ QRPHGARWAP
       730        740        750        760        770        780
NYDPLCSLCT CQRRTVICDP VVCPPPSCPH PVQAPDQCCP VCPEKQDVRD LPGLPRSRDP
       790        800        810        820        830        840
GEGCYFDGDR SWRAAGTRWH PVVPPFGLIK CAVCTCKGGT GEVHCEKVQC PRLACAQPVR
       850        860        870        880        890        900
VNPTDCCKQC PVGSGAHPQL GDPMQADGPR GCRFAGQWFP ESQSWHPSVP PFGEMSCITC
       910        920        930        940        950
RCGAGVPHCE RDDCSLPLSC GSGKESRCCS RCTAHRRPAP ETRTDPELEK EAEGS         10         20         30         40         50         60
MPSLPAPPAP LLLLGLLLLG SRPARGAGPE PPVLPIRSEK EPLPVRGAAG CTFGGKVYAL
        70         80         90        100        110        120
DETWHPDLGE PFGVMRCVLC ACEAPQWGRR TRGPGRVSCK NIKPECPTPA CGQPRQLPGH
       130        140        150        160        170        180
CCQTCPQERS SSERQPSGLS FEYPRDPEHR SYSDRGEPGA EERARGDGHT DFVALLTGPR
       190        200        210        220        230        240
SQAVARARVS LLRSSLRFSI SYRRLDRPTR IRFSDSNGSV LFEHPAAPTQ DGLVCGVWRA
       250        260        270        280        290        300
VPRLSLRLLR AEQLHVALVT LTHPSGEVWG PLIRHRALAA ETFSAILTLE GPPQQGVGGI
       310        320        330        340        350        360
TLLTLSDTED SLHFLLLFRG LLEPRSGGLT QVPLRLQILH QGQLLRELQA NVSAQEPGFA
       370        380        390        400        410        420
EVLPNLTVQE MDWLVLGELQ MALEWAGRPG LRISGHIAAR KSCDVLQSVL CGADALIPVQ
       430        440        450        460        470        480
TGAAGSASLT LLGNGSLIYQ VQVVGTSSEV VAMTLETKPQ RRDQRTVLCH MAGLQPGGHT
       490        500        510        520        530        540
AVGICPGLGA RGAHMLLQNE LFLNVGTKDF PDGELRGHVA ALPYCGHSAR HDTLPVPLAG
       550        560        570        580        590        600
ALVLPPVKSQ AAGHAWLSLD THCHLHYEVL LAGLGGSEQG TVTAHLLGPP GTPGPRRLLK
       610        620        630        640        650        660
GFYGSEAQGV VKDLEPELLR HLAKGMASLM ITTKGSPRGE LRGQVHIANQ CEVGGLRLEA
       670        680        690        700        710        720
AGAEGVRALG APDTASAAPP VVPGLPALAP AKPGGPGRPR DPNTCFFEGQ QRPHGARWAP
       730        740        750        760        770        780
NYDPLCSLCT CQRRTVICDP VVCPPPSCPH PVQAPDQCCP VCPEKQDVRD LPGLPRSRDP
       790        800        810        820        830        840
GEGCYFDGDR SWRAAGTRWH PVVPPFGLIK CAVCTCKGGT GEVHCEKVQC PRLACAQPVR
       850        860        870        880        890        900
VNPTDCCKQC PVGSGAHPQL GDPMQADGPR GCRFAGQWFP ESQSWHPSVP PFGEMSCITC
       910        920        930        940        950
RCGAGVPHCE RDDCSLPLSC GSGKESRCCS RCTAHRRPAP ETRTDPELEK EAEGS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9H2X0-1-unknown	MPSLPA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70596
Q9H2X0-1-unknown	MPSLPA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70597
Q9H2X0-1-unknown	MPSLPA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70598
Q9H2X0-1-unknown	MPSLPA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70599
Q9H2X0-27-unknown	AGPEPP...	27	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9H2X0-27-unknown	AGPEPP...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114171
Q9H2X0-27-unknown	AGPEPP...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114172
Q9H2X0-27-unknown	AGPEPP...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114173
Q9H2X0-27-unknown	AGPEPP...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114174
Q9H2X0-154-unknown	DRGEPG...	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31844
Q9H2X0-154-unknown	DRGEPG...	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC696
Q9H2X0-154-unknown	DRGEPG...	154	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144896
Q9H2X0-154-unknown	DRGEPG...	154	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144894
Q9H2X0-867-unknown	DGPRGC...	867	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31847
Q9H2X0-867-unknown	DGPRGC...	867	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC699
Q9H2X0-867-unknown	DGPRGC...	867	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156595

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HRSYSD	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31844
...HRSYSD	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC696
...HRSYSD	153	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128171
...HRSYSD	153	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128173
...DPMQAD	866	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31847
...DPMQAD	866	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC699
...DPMQAD	866	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140080
...EAEGS	955	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EAEGS	955	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66217

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
TLL1_HUMAN	153	SYSD.\|.DRGE	inferred from experiment	unknown	MEROPS	Greenspan DS	Scott IC et al.:Mammalian BMP-1/Tolloid-related... (M12.016)	10479448,
BMP1_HUMAN	153	SYSD.\|.DRGE	inferred from experiment	unknown	MEROPS	Greenspan DS	Scott IC et al.:Bone morphogenetic protein-1 pr... (M12.005)	10896944,
TLL1_HUMAN	866	MQAD.\|.DGPR	inferred from experiment	unknown	MEROPS	Greenspan DS	Scott IC et al.:Mammalian BMP-1/Tolloid-related... (M12.016)	10479448,
BMP1_HUMAN	866	MQAD.\|.DGPR	inferred from experiment	unknown	MEROPS	Greenspan DS	Scott IC et al.:Bone morphogenetic protein-1 pr... (M12.005)	10896944,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)