P07585: Decorin

General Information

Protein names	- Decorin - Bone proteoglycan II - PG-S2 - PG40
Gene names	DCN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P07585

10 N-termini

9 C-termini

13 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform B of Decorin - Isoform C of Decorin - Isoform D of Decorin - Isoform E of Decorin

Sequence View

        10         20         30         40         50         60
MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL GPVCPFRCQC
        70         80         90        100        110        120
HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD FKNLKNLHAL ILVNNKISKV
       130        140        150        160        170        180
SPGAFTPLVK LERLYLSKNQ LKELPEKMPK TLQELRAHEN EITKVRKVTF NGLNQMIVIE
       190        200        210        220        230        240
LGTNPLKSSG IENGAFQGMK KLSYIRIADT NITSIPQGLP PSLTELHLDG NKISRVDAAS
       250        260        270        280        290        300
LKGLNNLAKL GLSFNSISAV DNGSLANTPH LRELHLDNNK LTRVPGGLAE HKYIQVVYLH
       310        320        330        340        350
NNNISVVGSS DFCPPGHNTK KASYSGVSLF SNPVQYWEIQ PSTFRCVYVR SAIQLGNYK         10         20         30         40         50         60
MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL GPVCPFRCQC
        70         80         90        100        110        120
HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD FKNLKNLHAL ILVNNKISKV
       130        140        150        160        170        180
SPGAFTPLVK LERLYLSKNQ LKELPEKMPK TLQELRAHEN EITKVRKVTF NGLNQMIVIE
       190        200        210        220        230        240
LGTNPLKSSG IENGAFQGMK KLSYIRIADT NITSIPQGLP PSLTELHLDG NKISRVDAAS
       250        260        270        280        290        300
LKGLNNLAKL GLSFNSISAV DNGSLANTPH LRELHLDNNK LTRVPGGLAE HKYIQVVYLH
       310        320        330        340        350
NNNISVVGSS DFCPPGHNTK KASYSGVSLF SNPVQYWEIQ PSTFRCVYVR SAIQLGNYK         10         20         30         40         50         60
MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL GPVCPFRCQC
        70         80         90        100        110        120
HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD FKNLKNLHAL ILVNNKISKV
       130        140        150        160        170        180
SPGAFTPLVK LERLYLSKNQ LKELPEKMPK TLQELRAHEN EITKVRKVTF NGLNQMIVIE
       190        200        210        220        230        240
LGTNPLKSSG IENGAFQGMK KLSYIRIADT NITSIPQGLP PSLTELHLDG NKISRVDAAS
       250        260        270        280        290        300
LKGLNNLAKL GLSFNSISAV DNGSLANTPH LRELHLDNNK LTRVPGGLAE HKYIQVVYLH
       310        320        330        340        350
NNNISVVGSS DFCPPGHNTK KASYSGVSLF SNPVQYWEIQ PSTFRCVYVR SAIQLGNYK         10         20         30         40         50         60
MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL GPVCPFRCQC
        70         80         90        100        110        120
HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD FKNLKNLHAL ILVNNKISKV
       130        140        150        160        170        180
SPGAFTPLVK LERLYLSKNQ LKELPEKMPK TLQELRAHEN EITKVRKVTF NGLNQMIVIE
       190        200        210        220        230        240
LGTNPLKSSG IENGAFQGMK KLSYIRIADT NITSIPQGLP PSLTELHLDG NKISRVDAAS
       250        260        270        280        290        300
LKGLNNLAKL GLSFNSISAV DNGSLANTPH LRELHLDNNK LTRVPGGLAE HKYIQVVYLH
       310        320        330        340        350
NNNISVVGSS DFCPPGHNTK KASYSGVSLF SNPVQYWEIQ PSTFRCVYVR SAIQLGNYK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 9 C-termini - 13 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P07585-1-unknown	MKATII...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84997
P07585-1-unknown	MKATII...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84998
P07585-1-unknown	MKATII...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84999
P07585-1-unknown	MKATII...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85000
P07585-17-unknown	GPFQQR...	17	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P07585-17-unknown	GPFQQR...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111827
P07585-17-unknown	GPFQQR...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111828
P07585-17-unknown	GPFQQR...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111829
P07585-17-unknown	GPFQQR...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111830
P07585-31-unknown	DEASGI...	31	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P07585-31-unknown	DEASGI...	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23814
P07585-31-unknown	DEASGI...	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC656
P07585-31-unknown	DEASGI...	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24000
P07585-31-unknown	DEASGI...	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22508
P07585-31-unknown	DEASGI...	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114792
P07585-31-unknown	DEASGI...	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114793
P07585-31-unknown	DEASGI...	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114794
P07585-31-unknown	DEASGI...	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114795
P07585-32-unknown	EASGIG...	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24005
P07585-32-unknown	EASGIG...	32	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137742
P07585-32-unknown	EASGIG...	32	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137743
P07585-32-unknown	EASGIG...	32	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137744
P07585-32-unknown	EASGIG...	32	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137745
P07585-75-unknown	VPKDLP...	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC439
P07585-75-unknown	VPKDLP...	75	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140988
P07585-86-unknown	LDLQNN...	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC441
P07585-86-unknown	LDLQNN...	86	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141645
P07585-177-unknown	IVIELG...	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20136
P07585-188-unknown	SSGIEN...	188	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20137
P07585-188-unknown	SSGIEN...	188	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197946
P07585-241-unknown	LKGLNN...	241	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23819
P07585-241-unknown	LKGLNN...	241	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21372
P07585-241-unknown	LKGLNN...	241	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22513
P07585-241-unknown	LKGLNN...	241	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142059
P07585-241-unknown	LKGLNN...	241	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143955
P07585-274-unknown	LHLDNN...	274	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24010
P07585-274-unknown	LHLDNN...	274	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143790
P07585-274-unknown	LHLDNN...	274	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145350

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DFMLED	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23814
...DFMLED	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC656
...DFMLED	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24000
...DFMLED	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22508
...DFMLED	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120568
...DFMLED	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120570
...DFMLED	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120572
...DFMLED	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120575
...FMLEDE	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24005
...FMLEDE	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120741
...FMLEDE	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120742
...FMLEDE	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120743
...FMLEDE	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120744
...LGLDKV	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC439
...LGLDKV	74	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124136
...PDTTLL	85	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC441
...PDTTLL	85	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124825
...GLNQMI	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20136
...TNPLKS	187	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20137
...VDAASL	240	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23819
...VDAASL	240	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21372
...VDAASL	240	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22513
...VDAASL	240	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125242
...VDAASL	240	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127198
...PHLREL	273	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24010
...PHLREL	273	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127032
...PHLREL	273	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128642
...LGNYK	359	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LGNYK	359	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80617
...LGNYK	359	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80616
...LGNYK	359	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80615

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP3_HUMAN	30	MLED.\|.DEAS	inferred from experiment	unknown	MEROPS	Okada Y	Imai K et al.:Degradation of decorin by matri... (M10.003)	9148753,
BMP1_HUMAN	30	MLED.\|.DEAS	inferred from experiment	unknown	MEROPS	Greenspan DS	Scott IC et al.:Bone morphogenetic protein-1 pr... (M12.005)	10896944,
MMP7_HUMAN	30	MLED.\|.DEAS	inferred from experiment	unknown	MEROPS	Okada Y	Imai K et al.:Degradation of decorin by matri... (M10.003)	9148753,
MMP2_HUMAN	30	MLED.\|.DEAS	inferred from experiment	unknown	MEROPS	Okada Y	Imai K et al.:Degradation of decorin by matri... (M10.003)	9148753,
MMP7_HUMAN	31	LEDE.\|.EASG	inferred from experiment	unknown	MEROPS	Okada Y	Imai K et al.:Degradation of decorin by matri... (M10.003)	9148753,
ATS5_HUMAN	74	LDKV.\|.VPKD	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS5_HUMAN	85	TTLL.\|.LDLQ	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP12_HUMAN	176	NQMI.\|.IVIE	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP12_HUMAN	187	PLKS.\|.SSGI	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP3_HUMAN	240	AASL.\|.LKGL	inferred from experiment	unknown	MEROPS	Okada Y	Imai K et al.:Degradation of decorin by matri... (M10.003)	9148753,
MMP13_HUMAN	240	AASL.\|.LKGL	inferred from experiment	unknown	MEROPS	Martel-Pelletier J	Monfort J et al.:Degradation of small leucine-ri... (M10.013)	16507124,
MMP2_HUMAN	240	AASL.\|.LKGL	inferred from experiment	unknown	MEROPS	Okada Y	Imai K et al.:Degradation of decorin by matri... (M10.003)	9148753,
MMP7_HUMAN	273	LREL.\|.LHLD	inferred from experiment	unknown	MEROPS	Okada Y	Imai K et al.:Degradation of decorin by matri... (M10.003)	9148753,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)