P02647: Apolipoprotein A-I

General Information

Protein names	- Apolipoprotein A-I - Apo-AI - ApoA-I - Apolipoprotein A1 - Proapolipoprotein A-I - ProapoA-I - Truncated apolipoprotein A-I - Apolipoprotein A-I(1-242)
Gene names	APOA1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P02647

24 N-termini

12 C-termini

14 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKAAVLTLAV LFLTGSQARH FWQQDEPPQS PWDRVKDLAT VYVDVLKDSG RDYVSQFEGS
        70         80         90        100        110        120
ALGKQLNLKL LDNWDSVTST FSKLREQLGP VTQEFWDNLE KETEGLRQEM SKDLEEVKAK
       130        140        150        160        170        180
VQPYLDDFQK KWQEEMELYR QKVEPLRAEL QEGARQKLHE LQEKLSPLGE EMRDRARAHV
       190        200        210        220        230        240
DALRTHLAPY SDELRQRLAA RLEALKENGG ARLAEYHAKA TEHLSTLSEK AKPALEDLRQ
       250        260
GLLPVLESFK VSFLSALEEY TKKLNTQ

Isoforms

Sequence View

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

24 N-termini - 12 C-termini - 14 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P02647-19-unknown	RHFWQQ...	19	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P02647-25-unknown	DEPPQS...	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC654
P02647-25-unknown	DEPPQS...	25	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P02647-25-unknown	DEPPQS...	25		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02647-43-unknown	VDVLKD...	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8379
P02647-58-unknown	EGSALG...	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8380
P02647-131-unknown	KWQEEM...	131		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02647-146-unknown	LRAELQ...	146	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20029
P02647-146-unknown	LRAELQ...	146	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23972
P02647-148-unknown	AELQEG...	148		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02647-149-unknown	ELQEGA...	149		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02647-150-unknown	LQEGAR...	150	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23711
P02647-178-unknown	AHVDAL...	178		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02647-185-unknown	THLAPY...	185		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02647-186-unknown	HLAPYS...	186		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02647-199-unknown	AARLEA...	199		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02647-200-unknown	ARLEAL...	200		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02647-202-unknown	LEALKE...	202		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02647-204-unknown	ALKENG...	204		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02647-216-unknown	YHAKAT...	216	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20030
P02647-216-unknown	YHAKAT...	216	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23712
P02647-220-unknown	ATEHLS...	220		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02647-224-unknown	LSTLSE...	224	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20031
P02647-227-unknown	LSEKAK...	227	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23973
P02647-227-unknown	LSEKAK...	227		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02647-228-unknown	SEKAKP...	228		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02647-231-unknown	AKPALE...	231		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02647-238-unknown	LRQGLL...	238	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20032
P02647-238-unknown	LRQGLL...	238	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23974
P02647-250-unknown	KVSFLS...	250	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20033
P02647-250-unknown	KVSFLS...	250	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8381

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HFWQQD	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC654
...LATVYV	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8379
...YVSQFE	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8380
...QKVEPL	145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20029
...QKVEPL	145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23972
...PLRAEL	149	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23711
...ARLAEY	215	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20030
...ARLAEY	215	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23712
...KATEHL	223	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20031
...EHLSTL	226	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23973
...PALEDL	237	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20032
...PALEDL	237	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23974
...VLESFK	249	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20033
...VLESFK	249	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8381
...KKLNTQ	266	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KLNTQ	267	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
BMP1_HUMAN	24	WQQD.\|.DEPP	inferred from experiment	unknown	MEROPS	Fielding CJ	Chau P et al.:Bone morphogenetic protein-1 (B... (M12.005)	17580958,
CMA1_HUMAN	42	TVYV.\|.VDVL	inferred from experiment	unknown	MEROPS	Hellman L	Andersson MK et al.:The extended substrate specific... (S01.140)	19073880,
CMA1_HUMAN	57	SQFE.\|.EGSA	inferred from experiment	unknown	MEROPS	Hellman L	Andersson MK et al.:The extended substrate specific... (S01.140)	19073880,
MMP12_HUMAN	145	VEPL.\|.LRAE	inferred from experiment	unknown	MEROPS	Kovanen PT	Lindstedt L et al.:Matrix metalloproteinases-3, -7... (M10.009)	10428843,
MMP7_HUMAN	145	VEPL.\|.LRAE	inferred from experiment	unknown	MEROPS	Kovanen PT	Lindstedt L et al.:Matrix metalloproteinases-3, -7... (M10.009)	10428843,
MMP3_HUMAN	149	RAEL.\|.LQEG	inferred from experiment	unknown	MEROPS	Kovanen PT	Lindstedt L et al.:Matrix metalloproteinases-3, -7... (M10.009)	10428843,
MMP12_HUMAN	215	LAEY.\|.YHAK	inferred from experiment	unknown	MEROPS	Kovanen PT	Lindstedt L et al.:Matrix metalloproteinases-3, -7... (M10.009)	10428843,
MMP3_HUMAN	215	LAEY.\|.YHAK	inferred from experiment	unknown	MEROPS	Kovanen PT	Lindstedt L et al.:Matrix metalloproteinases-3, -7... (M10.009)	10428843,
MMP12_HUMAN	223	TEHL.\|.LSTL	inferred from experiment	unknown	MEROPS	Kovanen PT	Lindstedt L et al.:Matrix metalloproteinases-3, -7... (M10.009)	10428843,
MMP7_HUMAN	226	LSTL.\|.LSEK	inferred from experiment	unknown	MEROPS	Kovanen PT	Lindstedt L et al.:Matrix metalloproteinases-3, -7... (M10.009)	10428843,
MMP12_HUMAN	237	LEDL.\|.LRQG	inferred from experiment	unknown	MEROPS	Kovanen PT	Lindstedt L et al.:Matrix metalloproteinases-3, -7... (M10.009)	10428843,
MMP7_HUMAN	237	LEDL.\|.LRQG	inferred from experiment	unknown	MEROPS	Kovanen PT	Lindstedt L et al.:Matrix metalloproteinases-3, -7... (M10.009)	10428843,
MMP12_HUMAN	249	ESFK.\|.KVSF	inferred from experiment	unknown	MEROPS	Kovanen PT	Lindstedt L et al.:Matrix metalloproteinases-3, -7... (M10.009)	10428843,
CMA1_HUMAN	249	ESFK.\|.KVSF	inferred from experiment	unknown	MEROPS	Calabresi L	Lee M et al.:Apolipoprotein composition and ... (S01.140)	12562834,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)