P05997: Collagen alpha-2(V) chain

General Information

Protein names	- Collagen alpha-2(V) chain
Gene names	COL5A2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P05997

3 N-termini

3 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MMANWAEARP LLILIVLLGQ FVSIKAQEED EDEGYGEEIA CTQNGQMYLN RDIWKPAPCQ
        70         80         90        100        110        120
ICVCDNGAIL CDKIECQDVL DCADPVTPPG ECCPVCSQTP GGGNTNFGRG RKGQKGEPGL
       130        140        150        160        170        180
VPVVTGIRGR PGPAGPPGSQ GPRGERGPKG RPGPRGPQGI DGEPGVPGQP GAPGPPGHPS
       190        200        210        220        230        240
HPGPDGLSRP FSAQMAGLDE KSGLGSQVGL MPGSVGPVGP RGPQGLQGQQ GGAGPTGPPG
       250        260        270        280        290        300
EPGDPGPMGP IGSRGPEGPP GKPGEDGEPG RNGNPGEVGF AGSPGARGFP GAPGLPGLKG
       310        320        330        340        350        360
HRGHKGLEGP KGEVGAPGSK GEAGPTGPMG AMGPLGPRGM PGERGRLGPQ GAPGQRGAHG
       370        380        390        400        410        420
MPGKPGPMGP LGIPGSSGFP GNPGMKGEAG PTGARGPEGP QGQRGETGPP GPVGSPGLPG
       430        440        450        460        470        480
AIGTDGTPGA KGPTGSPGTS GPPGSAGPPG SPGPQGSTGP QGIRGQPGDP GVPGFKGEAG
       490        500        510        520        530        540
PKGEPGPHGI QGPIGPPGEE GKRGPRGDPG TVGPPGPVGE RGAPGNRGFP GSDGLPGPKG
       550        560        570        580        590        600
AQGERGPVGS SGPKGSQGDP GRPGEPGLPG ARGLTGNPGV QGPEGKLGPL GAPGEDGRPG
       610        620        630        640        650        660
PPGSIGIRGQ PGSMGLPGPK GSSGDPGKPG EAGNAGVPGQ RGAPGKDGEV GPSGPVGPPG
       670        680        690        700        710        720
LAGERGEQGP PGPTGFQGLP GPPGPPGEGG KPGDQGVPGD PGAVGPLGPR GERGNPGERG
       730        740        750        760        770        780
EPGITGLPGE KGMAGGHGPD GPKGSPGPSG TPGDTGPPGL QGMPGERGIA GTPGPKGDRG
       790        800        810        820        830        840
GIGEKGAEGT AGNDGARGLP GPLGPPGPAG PTGEKGEPGP RGLVGPPGSR GNPGSRGENG
       850        860        870        880        890        900
PTGAVGFAGP QGPDGQPGVK GEPGEPGQKG DAGSPGPQGL AGSPGPHGPN GVPGLKGGRG
       910        920        930        940        950        960
TQGPPGATGF PGSAGRVGPP GPAGAPGPAG PLGEPGKEGP PGLRGDPGSH GRVGDRGPAG
       970        980        990       1000       1010       1020
PPGGPGDKGD PGEDGQPGPD GPPGPAGTTG QRGIVGMPGQ RGERGMPGLP GPAGTPGKVG
      1030       1040       1050       1060       1070       1080
PTGATGDKGP PGPVGPPGSN GPVGEPGPEG PAGNDGTPGR DGAVGERGDR GDPGPAGLPG
      1090       1100       1110       1120       1130       1140
SQGAPGTPGP VGAPGDAGQR GDPGSRGPIG PPGRAGKRGL PGPQGPRGDK GDHGDRGDRG
      1150       1160       1170       1180       1190       1200
QKGHRGFTGL QGLPGPPGPN GEQGSAGIPG PFGPRGPPGP VGPSGKEGNP GPLGPIGPPG
      1210       1220       1230       1240       1250       1260
VRGSVGEAGP EGPPGEPGPP GPPGPPGHLT AALGDIMGHY DESMPDPLPE FTEDQAAPDD
      1270       1280       1290       1300       1310       1320
KNKTDPGVHA TLKSLSSQIE TMRSPDGSKK HPARTCDDLK LCHSAKQSGE YWIDPNQGSV
      1330       1340       1350       1360       1370       1380
EDAIKVYCNM ETGETCISAN PSSVPRKTWW ASKSPDNKPV WYGLDMNRGS QFAYGDHQSP
      1390       1400       1410       1420       1430       1440
NTAITQMTFL RLLSKEASQN ITYICKNSVG YMDDQAKNLK KAVVLKGAND LDIKAEGNIR
      1450       1460       1470       1480       1490
FRYIVLQDTC SKRNGNVGKT VFEYRTQNVA RLPIIDLAPV DVGGTDQEFG VEIGPVCFV

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P05997-27-unknown	QEEDED...	27	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P05997-943-unknown	LRGDPG...	943	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25634
P05997-1254-unknown	DQAAPD...	1254	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31834
P05997-1254-unknown	DQAAPD...	1254	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC655

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EGPPGL	942	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25634
...PPGHLT	1229	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PEFTED	1253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31834
...PEFTED	1253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC655

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP9_HUMAN	942	PPGL.\|.LRGD	inferred from experiment	unknown	MEROPS	Smith JW	Kridel SJ et al.:Substrate hydrolysis by matrix ... (M10.004)	11279151,
TLL1_HUMAN	1253	FTED.\|.DQAA	inferred from experiment	unknown	MEROPS	Greenspan DS	Ge G et al.:Bone morphogenetic protein-1/to... (M12.016)	15292192,
BMP1_HUMAN	1253	FTED.\|.DQAA	inferred from experiment	unknown	MEROPS	Greenspan DS	Unsold C et al.:Biosynthetic processing of the ... (M12.005)	11741999,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)