P02778: C-X-C motif chemokine 10

General Information

Protein names	- C-X-C motif chemokine 10 - 10 kDa interferon gamma-induced protein - Gamma-IP10 - IP-10 - Small-inducible cytokine B10 - CXCL10(1-73)
Gene names	CXCL10
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P02778

4 N-termini

5 C-termini

7 Cleavages

0 Substrates

Sequence

10 20 30 40 50 60
MNQTAILICC LIFLTLSGIQ GVPLSRTVRC TCISISNQPV NPRSLEKLEI IPASQFCPRV
70 80 90
EIIATMKKKG EKRCLNPESK AIKNLLKAVS KERSKRSP

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P02778-22-unknown	VPLSRT...	22	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P02778-24-unknown	LSRTVR...	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8480
P02778-24-unknown	LSRTVR...	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8504
P02778-90-unknown	SKERSK...	90	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25571
P02778-93-unknown	RSKRSP...	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20134
P02778-93-unknown	RSKRSP...	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25066

Name

Sequence

Position

Modification

Evidence type

Method

Source (database)

Source (Lab)

Evidence name

Publications (PMID)

P02778-22-unknown

VPLSRT...

inferred from electronic annotation

electronic annotation

UniProtKB

inferred from uniprot

P02778-24-unknown

LSRTVR...

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC8480

P02778-24-unknown

LSRTVR...

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC8504

P02778-90-unknown

SKERSK...

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC25571

P02778-93-unknown

RSKRSP...

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC20134

P02778-93-unknown

RSKRSP...

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC25066

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IQGVPL	23	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8480
...IQGVPL	23	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8504
...LLKAVS	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25571
...AVSKER	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20134
...AVSKER	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25066
...SKERSK	94	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SKERSK	94	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20135
...SKERSK	94	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25067
...SKRSP	98	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
DPP4_HUMAN	23	GVPL.\|.LSRT	inferred from experiment	unknown	MEROPS	De Meester I	Lambeir AM et al.:Kinetic investigation of chemok... (S09.003)	11390394,
DPP8_HUMAN	23	GVPL.\|.LSRT	inferred from experiment	unknown	MEROPS	Gorrell MD	Ajami K et al.:Stromal cell-derived factors 1a... (S09.003)	18275857,
MMP9_HUMAN	89	KAVS.\|.SKER	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,
MMP12_HUMAN	92	SKER.\|.RSKR	inferred from experiment	unknown	MEROPS	Overall CM	Cox JH et al.:Matrix metalloproteinase proces... (M10.009)	18411283,
MMP8_HUMAN	92	SKER.\|.RSKR	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,
MMP12_HUMAN	94	ERSK.\|.KRSP	inferred from experiment	unknown	MEROPS	Overall CM	Cox JH et al.:Matrix metalloproteinase proces... (M10.009)	18411283,
MMP8_HUMAN	94	ERSK.\|.KRSP	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,

Protease

Position

Sequence

Evidence type

Method

Source (database)

Source (Lab)

Evidence name

Publications (PMIDs)

DPP4_HUMAN

GVPL.|.LSRT

inferred from experiment

unknown

MEROPS

De Meester I

Lambeir AM et al.:Kinetic investigation of chemok... (S09.003)

11390394,

DPP8_HUMAN

GVPL.|.LSRT

inferred from experiment

unknown

MEROPS

Gorrell MD

Ajami K et al.:Stromal cell-derived factors 1a... (S09.003)

18275857,

MMP9_HUMAN

KAVS.|.SKER

inferred from experiment

unknown

MEROPS

Opdenakker G

Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)

14550288,

MMP12_HUMAN

SKER.|.RSKR

inferred from experiment

unknown

MEROPS

Overall CM

Cox JH et al.:Matrix metalloproteinase proces... (M10.009)

18411283,

MMP8_HUMAN

SKER.|.RSKR

inferred from experiment

unknown

MEROPS

Opdenakker G

Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)

14550288,

MMP12_HUMAN

ERSK.|.KRSP

inferred from experiment

unknown

MEROPS

Overall CM

Cox JH et al.:Matrix metalloproteinase proces... (M10.009)

18411283,

MMP8_HUMAN

ERSK.|.KRSP

inferred from experiment

unknown

MEROPS

Opdenakker G

Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)

14550288,

TopFIND

P02778: C-X-C motif chemokine 10

General Information

4

N-termini

5

C-termini

7

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

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Protein Neighborhood

Domains & Features

4 N-termini - 5 C-termini - 7 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates