Q6V1X1: Dipeptidyl peptidase 8

General Information

Protein names	- Dipeptidyl peptidase 8 - DP8 {ECO:0000303\|PubMed:12534281} - 3.4.14.5 {ECO:0000269\|PubMed:11012666, ECO:0000269\|PubMed:12534281, ECO:0000269\|PubMed:12662155, ECO:0000269\|PubMed:15039077, ECO:0000269\|PubMed:15664838, ECO:0000269\|PubMed:29382749} - Dipeptidyl peptidase IV-related protein 1 - DPRP-1 - Dipeptidyl peptidase VIII - DPP VIII - Prolyl dipeptidase DPP8
Gene names	DPP8
Organism	Homo sapiens
Protease Family	S09.018
Protease ID	S09.018
Chromosome location
UniProt ID	Q6V1X1

2 N-termini

1 C-termini

0 Cleavages

9 Substrates

Sequence

Isoforms

- Isoform 2 of Dipeptidyl peptidase 8 - Isoform 3 of Dipeptidyl peptidase 8 - Isoform 4 of Dipeptidyl peptidase 8 - Isoform 5 of Dipeptidyl peptidase 8 - Isoform 6 of Dipeptidyl peptidase 8

Sequence View

        10         20         30         40         50         60
MWKRSEQMKI KSGKCNMAAA METEQLGVEI FETADCEENI ESQDRPKLEP FYVERYSWSQ
        70         80         90        100        110        120
LKKLLADTRK YHGYMMAKAP HDFMFVKRND PDGPHSDRIY YLAMSGENRE NTLFYSEIPK
       130        140        150        160        170        180
TINRAAVLML SWKPLLDLFQ ATLDYGMYSR EEELLRERKR IGTVGIASYD YHQGSGTFLF
       190        200        210        220        230        240
QAGSGIYHVK DGGPQGFTQQ PLRPNLVETS CPNIRMDPKL CPADPDWIAF IHSNDIWISN
       250        260        270        280        290        300
IVTREERRLT YVHNELANME EDARSAGVAT FVLQEEFDRY SGYWWCPKAE TTPSGGKILR
       310        320        330        340        350        360
ILYEENDESE VEIIHVTSPM LETRRADSFR YPKTGTANPK VTFKMSEIMI DAEGRIIDVI
       370        380        390        400        410        420
DKELIQPFEI LFEGVEYIAR AGWTPEGKYA WSILLDRSQT RLQIVLISPE LFIPVEDDVM
       430        440        450        460        470        480
ERQRLIESVP DSVTPLIIYE ETTDIWINIH DIFHVFPQSH EEEIEFIFAS ECKTGFRHLY
       490        500        510        520        530        540
KITSILKESK YKRSSGGLPA PSDFKCPIKE EIAITSGEWE VLGRHGSNIQ VDEVRRLVYF
       550        560        570        580        590        600
EGTKDSPLEH HLYVVSYVNP GEVTRLTDRG YSHSCCISQH CDFFISKYSN QKNPHCVSLY
       610        620        630        640        650        660
KLSSPEDDPT CKTKEFWATI LDSAGPLPDY TPPEIFSFES TTGFTLYGML YKPHDLQPGK
       670        680        690        700        710        720
KYPTVLFIYG GPQVQLVNNR FKGVKYFRLN TLASLGYVVV VIDNRGSCHR GLKFEGAFKY
       730        740        750        760        770        780
KMGQIEIDDQ VEGLQYLASR YDFIDLDRVG IHGWSYGGYL SLMALMQRSD IFRVAIAGAP
       790        800        810        820        830        840
VTLWIFYDTG YTERYMGHPD QNEQGYYLGS VAMQAEKFPS EPNRLLLLHG FLDENVHFAH
       850        860        870        880        890
TSILLSFLVR AGKPYDLQIY PQERHSIRVP ESGEHYELHL LHYLQENLGS RIAALKVI         10         20         30         40         50         60
MWKRSEQMKI KSGKCNMAAA METEQLGVEI FETADCEENI ESQDRPKLEP FYVERYSWSQ
        70         80         90        100        110        120
LKKLLADTRK YHGYMMAKAP HDFMFVKRND PDGPHSDRIY YLAMSGENRE NTLFYSEIPK
       130        140        150        160        170        180
TINRAAVLML SWKPLLDLFQ ATLDYGMYSR EEELLRERKR IGTVGIASYD YHQGSGTFLF
       190        200        210        220        230        240
QAGSGIYHVK DGGPQGFTQQ PLRPNLVETS CPNIRMDPKL CPADPDWIAF IHSNDIWISN
       250        260        270        280        290        300
IVTREERRLT YVHNELANME EDARSAGVAT FVLQEEFDRY SGYWWCPKAE TTPSGGKILR
       310        320        330        340        350        360
ILYEENDESE VEIIHVTSPM LETRRADSFR YPKTGTANPK VTFKMSEIMI DAEGRIIDVI
       370        380        390        400        410        420
DKELIQPFEI LFEGVEYIAR AGWTPEGKYA WSILLDRSQT RLQIVLISPE LFIPVEDDVM
       430        440        450        460        470        480
ERQRLIESVP DSVTPLIIYE ETTDIWINIH DIFHVFPQSH EEEIEFIFAS ECKTGFRHLY
       490        500        510        520        530        540
KITSILKESK YKRSSGGLPA PSDFKCPIKE EIAITSGEWE VLGRHGSNIQ VDEVRRLVYF
       550        560        570        580        590        600
EGTKDSPLEH HLYVVSYVNP GEVTRLTDRG YSHSCCISQH CDFFISKYSN QKNPHCVSLY
       610        620        630        640        650        660
KLSSPEDDPT CKTKEFWATI LDSAGPLPDY TPPEIFSFES TTGFTLYGML YKPHDLQPGK
       670        680        690        700        710        720
KYPTVLFIYG GPQVQLVNNR FKGVKYFRLN TLASLGYVVV VIDNRGSCHR GLKFEGAFKY
       730        740        750        760        770        780
KMGQIEIDDQ VEGLQYLASR YDFIDLDRVG IHGWSYGGYL SLMALMQRSD IFRVAIAGAP
       790        800        810        820        830        840
VTLWIFYDTG YTERYMGHPD QNEQGYYLGS VAMQAEKFPS EPNRLLLLHG FLDENVHFAH
       850        860        870        880        890
TSILLSFLVR AGKPYDLQIY PQERHSIRVP ESGEHYELHL LHYLQENLGS RIAALKVI         10         20         30         40         50         60
MWKRSEQMKI KSGKCNMAAA METEQLGVEI FETADCEENI ESQDRPKLEP FYVERYSWSQ
        70         80         90        100        110        120
LKKLLADTRK YHGYMMAKAP HDFMFVKRND PDGPHSDRIY YLAMSGENRE NTLFYSEIPK
       130        140        150        160        170        180
TINRAAVLML SWKPLLDLFQ ATLDYGMYSR EEELLRERKR IGTVGIASYD YHQGSGTFLF
       190        200        210        220        230        240
QAGSGIYHVK DGGPQGFTQQ PLRPNLVETS CPNIRMDPKL CPADPDWIAF IHSNDIWISN
       250        260        270        280        290        300
IVTREERRLT YVHNELANME EDARSAGVAT FVLQEEFDRY SGYWWCPKAE TTPSGGKILR
       310        320        330        340        350        360
ILYEENDESE VEIIHVTSPM LETRRADSFR YPKTGTANPK VTFKMSEIMI DAEGRIIDVI
       370        380        390        400        410        420
DKELIQPFEI LFEGVEYIAR AGWTPEGKYA WSILLDRSQT RLQIVLISPE LFIPVEDDVM
       430        440        450        460        470        480
ERQRLIESVP DSVTPLIIYE ETTDIWINIH DIFHVFPQSH EEEIEFIFAS ECKTGFRHLY
       490        500        510        520        530        540
KITSILKESK YKRSSGGLPA PSDFKCPIKE EIAITSGEWE VLGRHGSNIQ VDEVRRLVYF
       550        560        570        580        590        600
EGTKDSPLEH HLYVVSYVNP GEVTRLTDRG YSHSCCISQH CDFFISKYSN QKNPHCVSLY
       610        620        630        640        650        660
KLSSPEDDPT CKTKEFWATI LDSAGPLPDY TPPEIFSFES TTGFTLYGML YKPHDLQPGK
       670        680        690        700        710        720
KYPTVLFIYG GPQVQLVNNR FKGVKYFRLN TLASLGYVVV VIDNRGSCHR GLKFEGAFKY
       730        740        750        760        770        780
KMGQIEIDDQ VEGLQYLASR YDFIDLDRVG IHGWSYGGYL SLMALMQRSD IFRVAIAGAP
       790        800        810        820        830        840
VTLWIFYDTG YTERYMGHPD QNEQGYYLGS VAMQAEKFPS EPNRLLLLHG FLDENVHFAH
       850        860        870        880        890
TSILLSFLVR AGKPYDLQIY PQERHSIRVP ESGEHYELHL LHYLQENLGS RIAALKVI         10         20         30         40         50         60
MWKRSEQMKI KSGKCNMAAA METEQLGVEI FETADCEENI ESQDRPKLEP FYVERYSWSQ
        70         80         90        100        110        120
LKKLLADTRK YHGYMMAKAP HDFMFVKRND PDGPHSDRIY YLAMSGENRE NTLFYSEIPK
       130        140        150        160        170        180
TINRAAVLML SWKPLLDLFQ ATLDYGMYSR EEELLRERKR IGTVGIASYD YHQGSGTFLF
       190        200        210        220        230        240
QAGSGIYHVK DGGPQGFTQQ PLRPNLVETS CPNIRMDPKL CPADPDWIAF IHSNDIWISN
       250        260        270        280        290        300
IVTREERRLT YVHNELANME EDARSAGVAT FVLQEEFDRY SGYWWCPKAE TTPSGGKILR
       310        320        330        340        350        360
ILYEENDESE VEIIHVTSPM LETRRADSFR YPKTGTANPK VTFKMSEIMI DAEGRIIDVI
       370        380        390        400        410        420
DKELIQPFEI LFEGVEYIAR AGWTPEGKYA WSILLDRSQT RLQIVLISPE LFIPVEDDVM
       430        440        450        460        470        480
ERQRLIESVP DSVTPLIIYE ETTDIWINIH DIFHVFPQSH EEEIEFIFAS ECKTGFRHLY
       490        500        510        520        530        540
KITSILKESK YKRSSGGLPA PSDFKCPIKE EIAITSGEWE VLGRHGSNIQ VDEVRRLVYF
       550        560        570        580        590        600
EGTKDSPLEH HLYVVSYVNP GEVTRLTDRG YSHSCCISQH CDFFISKYSN QKNPHCVSLY
       610        620        630        640        650        660
KLSSPEDDPT CKTKEFWATI LDSAGPLPDY TPPEIFSFES TTGFTLYGML YKPHDLQPGK
       670        680        690        700        710        720
KYPTVLFIYG GPQVQLVNNR FKGVKYFRLN TLASLGYVVV VIDNRGSCHR GLKFEGAFKY
       730        740        750        760        770        780
KMGQIEIDDQ VEGLQYLASR YDFIDLDRVG IHGWSYGGYL SLMALMQRSD IFRVAIAGAP
       790        800        810        820        830        840
VTLWIFYDTG YTERYMGHPD QNEQGYYLGS VAMQAEKFPS EPNRLLLLHG FLDENVHFAH
       850        860        870        880        890
TSILLSFLVR AGKPYDLQIY PQERHSIRVP ESGEHYELHL LHYLQENLGS RIAALKVI         10         20         30         40         50         60
MWKRSEQMKI KSGKCNMAAA METEQLGVEI FETADCEENI ESQDRPKLEP FYVERYSWSQ
        70         80         90        100        110        120
LKKLLADTRK YHGYMMAKAP HDFMFVKRND PDGPHSDRIY YLAMSGENRE NTLFYSEIPK
       130        140        150        160        170        180
TINRAAVLML SWKPLLDLFQ ATLDYGMYSR EEELLRERKR IGTVGIASYD YHQGSGTFLF
       190        200        210        220        230        240
QAGSGIYHVK DGGPQGFTQQ PLRPNLVETS CPNIRMDPKL CPADPDWIAF IHSNDIWISN
       250        260        270        280        290        300
IVTREERRLT YVHNELANME EDARSAGVAT FVLQEEFDRY SGYWWCPKAE TTPSGGKILR
       310        320        330        340        350        360
ILYEENDESE VEIIHVTSPM LETRRADSFR YPKTGTANPK VTFKMSEIMI DAEGRIIDVI
       370        380        390        400        410        420
DKELIQPFEI LFEGVEYIAR AGWTPEGKYA WSILLDRSQT RLQIVLISPE LFIPVEDDVM
       430        440        450        460        470        480
ERQRLIESVP DSVTPLIIYE ETTDIWINIH DIFHVFPQSH EEEIEFIFAS ECKTGFRHLY
       490        500        510        520        530        540
KITSILKESK YKRSSGGLPA PSDFKCPIKE EIAITSGEWE VLGRHGSNIQ VDEVRRLVYF
       550        560        570        580        590        600
EGTKDSPLEH HLYVVSYVNP GEVTRLTDRG YSHSCCISQH CDFFISKYSN QKNPHCVSLY
       610        620        630        640        650        660
KLSSPEDDPT CKTKEFWATI LDSAGPLPDY TPPEIFSFES TTGFTLYGML YKPHDLQPGK
       670        680        690        700        710        720
KYPTVLFIYG GPQVQLVNNR FKGVKYFRLN TLASLGYVVV VIDNRGSCHR GLKFEGAFKY
       730        740        750        760        770        780
KMGQIEIDDQ VEGLQYLASR YDFIDLDRVG IHGWSYGGYL SLMALMQRSD IFRVAIAGAP
       790        800        810        820        830        840
VTLWIFYDTG YTERYMGHPD QNEQGYYLGS VAMQAEKFPS EPNRLLLLHG FLDENVHFAH
       850        860        870        880        890
TSILLSFLVR AGKPYDLQIY PQERHSIRVP ESGEHYELHL LHYLQENLGS RIAALKVI

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 9 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q6V1X1-1-unknown	MWKRSE...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q6V1X1-1-unknown	MWKRSE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73210
Q6V1X1-1-unknown	MWKRSE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73213
Q6V1X1-1-unknown	MWKRSE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73214
Q6V1X1-17-unknown	MAAAME...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73211
Q6V1X1-17-unknown	MAAAME...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73212
Q6V1X1-17-unknown	MAAAME...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109807
Q6V1X1-17-unknown	MAAAME...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109808
Q6V1X1-17-unknown	MAAAME...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109809

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ALKVI	898	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ALKVI	898	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68832
...ALKVI	898	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68830
...ALKVI	898	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68828
...ALKVI	898	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68831
...ALKVI	898	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68829

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CXL11_HUMAN	23	GFPM.\|.MFKR	inferred from experiment	unknown	MEROPS	Gorrell MD	Ajami K et al.:Stromal cell-derived factors 1a... (S09.003)	18275857,
CXL10_HUMAN	23	GVPL.\|.LSRT	inferred from experiment	unknown	MEROPS	Gorrell MD	Ajami K et al.:Stromal cell-derived factors 1a... (S09.003)	18275857,
SDF1_HUMAN	23	GKPV.\|.VSLS	inferred from experiment	unknown	MEROPS	Gorrell MD	Ajami K et al.:Stromal cell-derived factors 1a... (S09.003)	18275857,
SDF1-Isoform7_HUMAN	23	GKPV.\|.VSLS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8505
SDF1-Isoform6_HUMAN	23	GKPV.\|.VSLS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8505
SDF1-Isoform5_HUMAN	23	GKPV.\|.VSLS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8505
SDF1-Isoform4_HUMAN	23	GKPV.\|.VSLS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8505
SDF1-Isoform3_HUMAN	23	GKPV.\|.VSLS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8505
SDF1-Isoform2_HUMAN	23	GKPV.\|.VSLS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8505