P35555: Fibrillin-1 {ECO:0000303|PubMed:15221638}

General Information

Protein names	- Fibrillin-1 {ECO:0000303\|PubMed:15221638} - Asprosin {ECO:0000303\|PubMed:27087445}
Gene names	FBN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P35555

4 N-termini

5 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRRGRLLEIA LGFTVLLASY TSHGADANLE AGNVKETRAS RAKRRGGGGH DALKGPNVCG
        70         80         90        100        110        120
SRYNAYCCPG WKTLPGGNQC IVPICRHSCG DGFCSRPNMC TCPSGQIAPS CGSRSIQHCN
       130        140        150        160        170        180
IRCMNGGSCS DDHCLCQKGY IGTHCGQPVC ESGCLNGGRC VAPNRCACTY GFTGPQCERD
       190        200        210        220        230        240
YRTGPCFTVI SNQMCQGQLS GIVCTKTLCC ATVGRAWGHP CEMCPAQPHP CRRGFIPNIR
       250        260        270        280        290        300
TGACQDVDEC QAIPGLCQGG NCINTVGSFE CKCPAGHKLN EVSQKCEDID ECSTIPGICE
       310        320        330        340        350        360
GGECTNTVSS YFCKCPPGFY TSPDGTRCID VRPGYCYTAL TNGRCSNQLP QSITKMQCCC
       370        380        390        400        410        420
DAGRCWSPGV TVAPEMCPIR ATEDFNKLCS VPMVIPGRPE YPPPPLGPIP PVLPVPPGFP
       430        440        450        460        470        480
PGPQIPVPRP PVEYLYPSRE PPRVLPVNVT DYCQLVRYLC QNGRCIPTPG SYRCECNKGF
       490        500        510        520        530        540
QLDLRGECID VDECEKNPCA GGECINNQGS YTCQCRAGYQ STLTRTECRD IDECLQNGRI
       550        560        570        580        590        600
CNNGRCINTD GSFHCVCNAG FHVTRDGKNC EDMDECSIRN MCLNGMCINE DGSFKCICKP
       610        620        630        640        650        660
GFQLASDGRY CKDINECETP GICMNGRCVN TDGSYRCECF PGLAVGLDGR VCVDTHMRST
       670        680        690        700        710        720
CYGGYKRGQC IKPLFGAVTK SECCCASTEY AFGEPCQPCP AQNSAEYQAL CSSGPGMTSA
       730        740        750        760        770        780
GSDINECALD PDICPNGICE NLRGTYKCIC NSGYEVDSTG KNCVDINECV LNSLLCDNGQ
       790        800        810        820        830        840
CRNTPGSFVC TCPKGFIYKP DLKTCEDIDE CESSPCINGV CKNSPGSFIC ECSSESTLDP
       850        860        870        880        890        900
TKTICIETIK GTCWQTVIDG RCEININGAT LKSQCCSSLG AAWGSPCTLC QVDPICGKGY
       910        920        930        940        950        960
SRIKGTQCED IDECEVFPGV CKNGLCVNTR GSFKCQCPSG MTLDATGRIC LDIRLETCFL
       970        980        990       1000       1010       1020
RYEDEECTLP IAGRHRMDAC CCSVGAAWGT EECEECPMRN TPEYEELCPR GPGFATKEIT
      1030       1040       1050       1060       1070       1080
NGKPFFKDIN ECKMIPSLCT HGKCRNTIGS FKCRCDSGFA LDSEERNCTD IDECRISPDL
      1090       1100       1110       1120       1130       1140
CGRGQCVNTP GDFECKCDEG YESGFMMMKN CMDIDECQRD PLLCRGGVCH NTEGSYRCEC
      1150       1160       1170       1180       1190       1200
PPGHQLSPNI SACIDINECE LSAHLCPNGR CVNLIGKYQC ACNPGYHSTP DRLFCVDIDE
      1210       1220       1230       1240       1250       1260
CSIMNGGCET FCTNSEGSYE CSCQPGFALM PDQRSCTDID ECEDNPNICD GGQCTNIPGE
      1270       1280       1290       1300       1310       1320
YRCLCYDGFM ASEDMKTCVD VNECDLNPNI CLSGTCENTK GSFICHCDMG YSGKKGKTGC
      1330       1340       1350       1360       1370       1380
TDINECEIGA HNCGKHAVCT NTAGSFKCSC SPGWIGDGIK CTDLDECSNG THMCSQHADC
      1390       1400       1410       1420       1430       1440
KNTMGSYRCL CKEGYTGDGF TCTDLDECSE NLNLCGNGQC LNAPGGYRCE CDMGFVPSAD
      1450       1460       1470       1480       1490       1500
GKACEDIDEC SLPNICVFGT CHNLPGLFRC ECEIGYELDR SGGNCTDVNE CLDPTTCISG
      1510       1520       1530       1540       1550       1560
NCVNTPGSYI CDCPPDFELN PTRVGCVDTR SGNCYLDIRP RGDNGDTACS NEIGVGVSKA
      1570       1580       1590       1600       1610       1620
SCCCSLGKAW GTPCEMCPAV NTSEYKILCP GGEGFRPNPI TVILEDIDEC QELPGLCQGG
      1630       1640       1650       1660       1670       1680
KCINTFGSFQ CRCPTGYYLN EDTRVCDDVN ECETPGICGP GTCYNTVGNY TCICPPDYMQ
      1690       1700       1710       1720       1730       1740
VNGGNNCMDM RRSLCYRNYY ADNQTCDGEL LFNMTKKMCC CSYNIGRAWN KPCEQCPIPS
      1750       1760       1770       1780       1790       1800
TDEFATLCGS QRPGFVIDIY TGLPVDIDEC REIPGVCENG VCINMVGSFR CECPVGFFYN
      1810       1820       1830       1840       1850       1860
DKLLVCEDID ECQNGPVCQR NAECINTAGS YRCDCKPGYR FTSTGQCNDR NECQEIPNIC
      1870       1880       1890       1900       1910       1920
SHGQCIDTVG SFYCLCHTGF KTNDDQTMCL DINECERDAC GNGTCRNTIG SFNCRCNHGF
      1930       1940       1950       1960       1970       1980
ILSHNNDCID VDECASGNGN LCRNGQCINT VGSFQCQCNE GYEVAPDGRT CVDINECLLE
      1990       2000       2010       2020       2030       2040
PRKCAPGTCQ NLDGSYRCIC PPGYSLQNEK CEDIDECVEE PEICALGTCS NTEGSFKCLC
      2050       2060       2070       2080       2090       2100
PEGFSLSSSG RRCQDLRMSY CYAKFEGGKC SSPKSRNHSK QECCCALKGE GWGDPCELCP
      2110       2120       2130       2140       2150       2160
TEPDEAFRQI CPYGSGIIVG PDDSAVDMDE CKEPDVCKHG QCINTDGSYR CECPFGYILA
      2170       2180       2190       2200       2210       2220
GNECVDTDEC SVGNPCGNGT CKNVIGGFEC TCEEGFEPGP MMTCEDINEC AQNPLLCAFR
      2230       2240       2250       2260       2270       2280
CVNTYGSYEC KCPVGYVLRE DRRMCKDEDE CEEGKHDCTE KQMECKNLIG TYMCICGPGY
      2290       2300       2310       2320       2330       2340
QRRPDGEGCV DENECQTKPG ICENGRCLNT RGSYTCECND GFTASPNQDE CLDNREGYCF
      2350       2360       2370       2380       2390       2400
TEVLQNMCQI GSSNRNPVTK SECCCDGGRG WGPHCEICPF QGTVAFKKLC PHGRGFMTNG
      2410       2420       2430       2440       2450       2460
ADIDECKVIH DVCRNGECVN DRGSYHCICK TGYTPDITGT SCVDLNECNQ APKPCNFICK
      2470       2480       2490       2500       2510       2520
NTEGSYQCSC PKGYILQEDG RSCKDLDECA TKQHNCQFLC VNTIGGFTCK CPPGFTQHHT
      2530       2540       2550       2560       2570       2580
SCIDNNECTS DINLCGSKGI CQNTPGSFTC ECQRGFSLDQ TGSSCEDVDE CEGNHRCQHG
      2590       2600       2610       2620       2630       2640
CQNIIGGYRC SCPQGYLQHY QWNQCVDENE CLSAHICGGA SCHNTLGSYK CMCPAGFQYE
      2650       2660       2670       2680       2690       2700
QFSGGCQDIN ECGSAQAPCS YGCSNTEGGY LCGCPPGYFR IGQGHCVSGM GMGRGNPEPP
      2710       2720       2730       2740       2750       2760
VSGEMDDNSL SPEACYECKI NGYPKRGRKR RSTNETDASN IEDQSETEAN VSLASWDVEK
      2770       2780       2790       2800       2810       2820
TAIFAFNISH VSNKVRILEL LPALTTLTNH NRYLIESGNE DGFFKINQKE GISYLHFTKK
      2830       2840       2850       2860       2870
KPVAGTYSLQ ISSTPLYKKK ELNQLEDKYD KDYLSGELGD NLKMKIQVLL H

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 5 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P35555-28-unknown	NLEAGN...	28	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P35555-449-unknown	VTDYCQ...	449	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26407
P35555-449-unknown	VTDYCQ...	449	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21403
P35555-2046-unknown	LSSSGR...	2046	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21266
P35555-2732-unknown	STNETD...	2732	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26624
P35555-2732-unknown	STNETD...	2732	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26894
P35555-2732-unknown	STNETD...	2732	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9765
P35555-2732-unknown	STNETD...	2732	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27192
P35555-2732-unknown	STNETD...	2732	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27041
P35555-2732-unknown	STNETD...	2732	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27338
P35555-2732-unknown	STNETD...	2732	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DALKGP	55	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453901
...VLPVNV	448	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26407
...VLPVNV	448	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21403
...PEGFSL	2045	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21266
...GRKRRS	2731	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26624
...GRKRRS	2731	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26894
...GRKRRS	2731	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9765
...GRKRRS	2731	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27192
...GRKRRS	2731	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27041
...GRKRRS	2731	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27338
...GRKRRS	2731	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QVLLH	2871	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP9_HUMAN	448	PVNV.\|.VTDY	inferred from experiment	unknown	MEROPS	Kielty CM	Hindson VJ et al.:Fibrillin degradation by matrix... (M10.009)	10386589,
MMP13_HUMAN	448	PVNV.\|.VTDY	inferred from experiment	unknown	MEROPS	Kielty CM	Hindson VJ et al.:Fibrillin degradation by matrix... (M10.009)	10386589,
MMP12_HUMAN	2045	GFSL.\|.LSSS	inferred from experiment	unknown	MEROPS	Kielty CM	Hindson VJ et al.:Fibrillin degradation by matrix... (M10.009)	10386589,
NEC2_HUMAN	2731	KRRS.\|.STNE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	2731	KRRS.\|.STNE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	2731	KRRS.\|.STNE	inferred from experiment	unknown	MEROPS	Jewett T	Milewicz DM et al.:A mutation in FBN1 disrupts pro... (S08.071)	7738200,
PCSK6_HUMAN	2731	KRRS.\|.STNE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK5_HUMAN	2731	KRRS.\|.STNE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	2731	KRRS.\|.STNE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)