P51888: Prolargin

General Information

Protein names	- Prolargin - Proline-arginine-rich end leucine-rich repeat protein
Gene names	PRELP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P51888

34 N-termini

34 C-termini

38 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRSPLCWLLP LLILASVAQG QPTRRPRPGT GPGRRPRPRP RPTPSFPQPD EPAEPTDLPP
        70         80         90        100        110        120
PLPPGPPSIF PDCPRECYCP PDFPSALYCD SRNLRKVPVI PPRIHYLYLQ NNFITELPVE
       130        140        150        160        170        180
SFQNATGLRW INLDNNRIRK IDQRVLEKLP GLVFLYMEKN QLEEVPSALP RNLEQLRLSQ
       190        200        210        220        230        240
NHISRIPPGV FSKLENLLLL DLQHNRLSDG VFKPDTFHGL KNLMQLNLAH NILRKMPPRV
       250        260        270        280        290        300
PTAIHQLYLD SNKIETIPNG YFKSFPNLAF IRLNYNKLTD RGLPKNSFNI SNLLVLHLSH
       310        320        330        340        350        360
NRISSVPAIN NRLEHLYLNN NSIEKINGTQ ICPNDLVAFH DFSSDLENVP HLRYLRLDGN
       370        380
YLKPPIPLDL MMCFRLLQSV VI

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

34 N-termini - 34 C-termini - 38 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P51888-21-unknown	QPTRRP...	21	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P51888-142-unknown	DQRVLE...	142	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC375
P51888-145-unknown	VLEKLP...	145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC376
P51888-154-unknown	FLYMEK...	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC377
P51888-156-unknown	YMEKNQ...	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21269
P51888-156-unknown	YMEKNQ...	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23937
P51888-157-unknown	MEKNQL...	157	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC378
P51888-158-unknown	EKNQLE...	158	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC379
P51888-159-unknown	KNQLEE...	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC380
P51888-160-unknown	NQLEEV...	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC381
P51888-173-unknown	LEQLRL...	173	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25095
P51888-173-unknown	LEQLRL...	173	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21270
P51888-176-unknown	LRLSQN...	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23938
P51888-177-unknown	RLSQNH...	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC382
P51888-182-unknown	HISRIP...	182	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25096
P51888-182-unknown	HISRIP...	182	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21271
P51888-197-unknown	LLLLDL...	197	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21272
P51888-201-unknown	DLQHNR...	201	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC383
P51888-202-unknown	LQHNRL...	202	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25097
P51888-217-unknown	FHGLKN...	217	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25098
P51888-217-unknown	FHGLKN...	217	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC384
P51888-223-unknown	LMQLNL...	223	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25099
P51888-250-unknown	DSNKIE...	250	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC385
P51888-251-unknown	SNKIET...	251	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC386
P51888-262-unknown	FKSFPN...	262	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC387
P51888-265-unknown	FPNLAF...	265	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC388
P51888-274-unknown	NYNKLT...	274	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC389
P51888-299-unknown	SHNRIS...	299	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21273
P51888-316-unknown	LYLNNN...	316	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21274
P51888-339-unknown	FHDFSS...	339	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21418
P51888-340-unknown	HDFSSD...	340	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21419
P51888-341-unknown	DFSSDL...	341	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC390
P51888-341-unknown	DFSSDL...	341	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC465
P51888-352-unknown	LRYLRL...	352	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC466
P51888-354-unknown	YLRLDG...	354	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21420
P51888-355-unknown	LRLDGN...	355	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21421
P51888-356-unknown	RLDGNY...	356	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC391
P51888-358-unknown	DGNYLK...	358	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC392
P51888-372-unknown	MCFRLL...	372	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC393

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RIRKID	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC375
...KIDQRV	144	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC376
...LPGLVF	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC377
...GLVFLY	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21269
...GLVFLY	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23937
...LVFLYM	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC378
...VFLYME	157	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC379
...FLYMEK	158	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC380
...LYMEKN	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC381
...ALPRNL	172	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25095
...ALPRNL	172	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21270
...RNLEQL	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23938
...NLEQLR	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC382
...RLSQNH	181	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25096
...RLSQNH	181	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21271
...SKLENL	196	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21272
...NLLLLD	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC383
...LLLLDL	201	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25097
...FKPDTF	216	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25098
...FKPDTF	216	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC384
...HGLKNL	222	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25099
...HQLYLD	249	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC385
...QLYLDS	250	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC386
...IPNGYF	261	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC387
...GYFKSF	264	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC388
...AFIRLN	273	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC389
...LVLHLS	298	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21273
...NRLEHL	315	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21274
...NDLVAF	338	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21418
...DLVAFH	339	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21419
...LVAFHD	340	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC390
...LVAFHD	340	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC465
...ENVPHL	351	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC466
...VPHLRY	353	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21420
...PHLRYL	354	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21421
...HLRYLR	355	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC391
...RYLRLD	357	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC392
...PLDLMM	371	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC393
...QSVVI	382	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ATS4_HUMAN	141	RKID.\|.DQRV	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	144	DQRV.\|.VLEK	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	153	GLVF.\|.FLYM	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP12_HUMAN	155	VFLY.\|.YMEK	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP3_HUMAN	155	VFLY.\|.YMEK	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	156	FLYM.\|.MEKN	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	157	LYME.\|.EKNQ	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	158	YMEK.\|.KNQL	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	159	MEKN.\|.NQLE	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP8_HUMAN	172	PRNL.\|.LEQL	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP12_HUMAN	172	PRNL.\|.LEQL	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP3_HUMAN	175	LEQL.\|.LRLS	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	176	EQLR.\|.RLSQ	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP8_HUMAN	181	SQNH.\|.HISR	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP12_HUMAN	181	SQNH.\|.HISR	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP12_HUMAN	196	LENL.\|.LLLL	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	200	LLLD.\|.DLQH	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP8_HUMAN	201	LLDL.\|.LQHN	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP8_HUMAN	216	PDTF.\|.FHGL	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	216	PDTF.\|.FHGL	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP8_HUMAN	222	LKNL.\|.LMQL	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	249	LYLD.\|.DSNK	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	250	YLDS.\|.SNKI	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	261	NGYF.\|.FKSF	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	264	FKSF.\|.FPNL	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	273	IRLN.\|.NYNK	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP12_HUMAN	298	LHLS.\|.SHNR	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP12_HUMAN	315	LEHL.\|.LYLN	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP13_HUMAN	338	LVAF.\|.FHDF	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP13_HUMAN	339	VAFH.\|.HDFS	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	340	AFHD.\|.DFSS	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS5_HUMAN	340	AFHD.\|.DFSS	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS5_HUMAN	351	VPHL.\|.LRYL	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP13_HUMAN	353	HLRY.\|.YLRL	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP13_HUMAN	354	LRYL.\|.LRLD	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	355	RYLR.\|.RLDG	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	357	LRLD.\|.DGNY	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	371	DLMM.\|.MCFR	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)