P22361: Hepatocyte nuclear factor 1-alpha
| Protein names | - Hepatocyte nuclear factor 1-alpha - HNF-1-alpha - HNF-1A - Liver-specific transcription factor LF-B1 - LFB1 - Transcription factor 1 - TCF-1 |
|---|---|
| Gene names | Hnf1a |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | P22361 |
5
N-termini
5
C-termini
5
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MVSKLSQLQT ELLAALLESG LSKEALIQAL GEPGPYLMVG EGPLDKGESC GGSRGDLTEL
70 80 90 100 110 120
PNGLGETRGS EDDTDDDGED FAPPILKELE NLSPEEAAHQ KAVVESLLQE DPWRVAKMVK
130 140 150 160 170 180
SYLQQHNIPQ REVVDTTGLN QSHLSQHLNK GTPMKTQKRA ALYTWYVRKQ REVAQQFTHA
190 200 210 220 230 240
GQGGLIEEPT GDELPTKKGR RNRFKWGPAS QQILFQAYER QKNPSKEERE TLVEECNRAE
250 260 270 280 290 300
CIQRGVSPSQ AQGLGSNLVT EVRVYNWFAN RRKEEAFRHK LAMDTYNGPP PGPGPGPALP
310 320 330 340 350 360
AHSSPGLPTT TLSPSKVHGV RYGQSATSEA AEVPSSSGGP LVTVSAALHQ VSPTGLEPSS
370 380 390 400 410 420
LLSTEAKLVS ATGGPLPPVS TLTALHSLEQ TSPGLNQQPQ NLIMASLPGV MTIGPGEPAS
430 440 450 460 470 480
LGPTFTNTGA STLVIGLAST QAQSVPVINS MGSSLTTLQP VQFSQPLHPS YQQPLMPPVQ
490 500 510 520 530 540
SHVAQSPFMA TMAQLQSPHA LYSHKPEVAQ YTHTSLLPQT MLITDTNLST LASLTPTKQV
550 560 570 580 590 600
FTSDTEASSE PGLHEPPSPA TTIHIPSQDP SNIQHLQPAH RLSTSPTVSS SSLVLYQSSD
610 620
SNGHSHLLPS NHSVIETFIS TQMASSSQ
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
5 N-termini - 5 C-termini - 5 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P22361-1-unknown | MVSKLS... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P22361-6-unknown | SQLQTE... | 6 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34891 | |||
| P22361-7-unknown | QLQTEL... | 7 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34873 | |||
| P22361-8-unknown | LQTELL... | 8 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34950 | |||
| P22361-8-unknown | LQTELL... | 8 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34990 | |||
| P22361-71-unknown | EDDTDD... | 71 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34989 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...MVSKLS | 5 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34891 | |||
| ...VSKLSQ | 6 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34873 | |||
| ...SKLSQL | 7 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34950 | |||
| ...SKLSQL | 7 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34990 | |||
| ...ETRGSE | 70 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34989 | |||
| ...ASSSQ | 628 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| MMP13_HUMAN | 5 | SKLS.|.SQLQ | MS other | Overall Lab | recMMP-Chemokine_AStarr2012A | 22147696, | ||
| MMP12_HUMAN | 6 | KLSQ.|.QLQT | MS other | Overall Lab | recMMP-Chemokine_AStarr2012A | 22147696, | ||
| MMP3_HUMAN | 7 | LSQL.|.LQTE | MS other | Overall Lab | recMMP-Chemokine_AStarr2012A | 22147696, | ||
| MMP7_HUMAN | 7 | LSQL.|.LQTE | MS other | Overall Lab | recMMP-Chemokine_AStarr2012A | 22147696, | ||
| MMP7_HUMAN | 70 | RGSE.|.EDDT | MS other | Overall Lab | recMMP-Chemokine_AStarr2012A | 22147696, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|